Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A. [PDF]
Int J Mol Sci, 2018 Chang TS +4 more
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Distribution of uridine diphosphate glucuronosyltransferase 1A polymorphisms and their role in irinotecan-induced toxicity in patients with cancer. [PDF]
Oncol Lett, 2017 Wang Y +8 more
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Osmolality-Independent Impact of Sodium on Glycosylation of an Fc-Fusion Protein and the Hexosamine Biosynthesis Pathway in a Chinese Hamster Ovary Cell Line. [PDF]
Biotechnol JReiniger J +3 more
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Measurements of uridine diphosphate glucose and uridine diphosphate galactose — an appraisal
European Journal of Pediatrics, 1995The recent disproof of a major deficiency of uridine diphosphate galactose in galactosemia should not lead investigators to assume either that enzymatic methods are unreliable for uridine sugar assays or that a defect in galactosylation in galactosemia has been excluded.
Henry N Kirkman, Kirkman Henry N
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STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES
Clinical and Experimental Pharmacology and Physiology, 1997SUMMARY1. The uridine diphosphate (UDP)‐glucuronosyltransferases (UGT) are a family of enzymes that catalyse the covalent addition of glucuronic acid to a wide range of lipophilic chemicals. They play a major role in the detoxification of many exogenous and endogenous compounds by generating products that are more polar and, thus, more readily excreted
Robyn Meech, Peter I Mackenzie
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Preparation of uridine diphosphogalactose and uridine diphosphate
Analytical Biochemistry, 1964Abstract A procedure for the production of UDP-Gal and UDP on a preparative scale has been elaborated using a bacterial mutant which accumulates UDP-Gal in the presence of galactose. This method provides several possibilities for labeling these compounds with radioactive isotopes.
A E, SHEDLOVSKY, H A, BOYE, S, BRENNER
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Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases
Expert Opinion on Drug Metabolism & Toxicology, 2015The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Zoe, Riches, Abby C, Collier
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Publisher Summary This chapter describes the isolation of uridine diphosphate glucose, uridine diphosphate acetylglucosamine, and guanosine diphosphate mannose. The basic principle is that alcoholic extract from toluene-autolyzed yeast is fractionated on anion-exchange columns.
Luis F. Leloir, Enrico Cabib
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Deficit of uridine diphosphate galactose in galactosaemia
Journal of Inherited Metabolic Disease, 1989SummaryThe levels of uridine diphosphate galactose (UDPGal) and uridine diphosphate glucose (UDPGlc) have been determined in liver autopsy samples, erythrocytes and cultured skin fibroblasts from galactosaemic patients and compared to non‐galactosaemic controls.
W G, Ng +3 more
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Uridine diphosphate glucuronosyltransferase 1A1
Xenobiotica, 2019The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
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