Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver. [PDF]
Clin Pharmacol Ther, 2019 The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was investigated by determining their protein abundance in human liver microsomes isolated from 136 pediatric (0–18 years) and 35 adult (age >18 years) donors using liquid ...
Bhatt DK +12 more
europepmc +2 more sources
Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A. [PDF]
Int J Mol Sci, 2018 Bacillus subtilis ATCC (American type culture collection) 6633 was found to biotransform ganoderic acid A (GAA), which is a major lanostane triterpenoid from the medicinal fungus Ganoderma lucidum.
Chang TS +4 more
europepmc +2 more sources
Could Postnatal Age–Related Uridine Diphosphate Glucuronic Acid Be a Rate‐Limiting Factor in the Metabolism of Morphine During the First Week of Life? [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body
Tao Liu +8 more
doaj +2 more sources
URIDINE DIPHOSPHATE ACETYLGLUCOSAMINE [PDF]
Journal of Biological Chemistry, 1953 Blanco y ...
Cabib, Enrico +2 more
openaire +6 more sources
Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans. [PDF]
J Org Chem, 2017 Unnatural chemically modified nucleotide sugars UDP-4-N3-GlcNAc and UDP-4-N3-GalNAc were chemically synthesized for the first time. These unnatural UDP sugar products were then tested for incorporation into hyaluronan, heparosan, or chondroitin using ...
Zhang X +9 more
europepmc +2 more sources
Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function? [PDF]
Pharmaceutics, 2017 Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Liu Y, Coughtrie MWH.
europepmc +2 more sources
Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases
Frontiers in PhysiologyUridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a concentration higher than the other nucleosides. As a simple metabolite, uridine plays a pivotal role in various biological processes. In addition to nucleic acid synthesis,
Yueyuan Yang +3 more
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Uridine Diphosphate-4-Keto-Glucose, an Intermediate in the Uridine Diphosphate-Galactose-4-Epimerase Reaction [PDF]
Proceedings of the National Academy of Sciences, 1971 When UDP-galactose 4-epimerase (EC 5.1.3.2) from Escherichia coli is incubated with UDP-galactose, then reduced with NaB 3 H 4 , label is found in UDP-glucose and UDP-galactose.
Utpalendu S. Maitra, Helmut Ankel
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Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans. [PDF]
The Journal of Organic Chemistry, 2012 Eight N-acetylglucosamine-1-phosphate and N-acetylgalactosamine-1-phosphate analogs have been synthesized chemically and were tested for their recognition by the GlmU uridyltransferase enzyme.
Sayaka Masuko +6 more
semanticscholar +4 more sources
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are associated with insecticide resistance in the major malaria vectors Anopheles gambiae s.l. and Anopheles funestus [PDF]
Scientific ReportsMalaria remains one of the highest causes of morbidity and mortality, with 249 million cases and over 608,000 deaths in 2022. Insecticides, which target the Anopheles mosquito vector, are the primary method to control malaria.
Rhiannon Agnes Ellis Logan +3 more
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