Results 91 to 100 of about 12,547 (216)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Incorporation of 14C-glucose into glycogen by whole homogenate of liver [PDF]

, 1962
IT has been reported that in liver slices glucose is a better precursor of glycogen than glucose 6-phosphate and glucose 1-phosphate1,2. To explain these results and others in the literature, a new pathway from glucose to glycogen was postulated that ...
Figueroa, Enrique, Pfeifer, Ariana, Niemeyer, Hermann   +2 more
core   +1 more source

Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis

Nature Communications
Collagen glucosyltransferases catalyze collagen glucosylation critical for biology and diseases, yet their structural regulation remains unclear. Here, we report crystal structures of a mimiviral collagen glucosyltransferase in its apo form and in ...
Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J. Richards, Tingfei Chen, Jingjing Wu, Ronald C. Bruntz, Marisa E. Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo   +12 more
doaj   +1 more source

CRISPR/Cas9-Based Functional Characterization of SfUGT50A15 Reveals Its Roles in the Resistance of Spodoptera frugiperda to Chlorantraniliprole, Emamectin Benzoate, and Benzoxazinoids

Insects
UDP-glycosyltransferases (UGTs) are a diverse superfamily of enzymes. Insects utilize uridine diphosphate-glucose (UDP-glucose) as a glycosyl donor for glycosylation in vivo, involved in the glycosylation of lipophilic endosymbionts and xenobiotics ...
Zhan Shi, Mei Luo, Jinxi Yuan, Bin Gao, Minghuan Yang, Guirong Wang   +5 more
doaj   +1 more source

Enhancing Glycosylation of Flavonoids by Engineering the Uridine Diphosphate Glucose Supply in Escherichia coli

Glycosylation can enhance the solubility and stability of flavonoids. The main limitation of the glycosylation process is low intracellular uridine diphosphate glucose (UDPG) availability.
Jingwen Zhou (591817), Shike Liu (6287315), Weizhu Zeng (6523394), Zhijie Qin (9941580), Dong Li (212687)   +4 more
core   +1 more source

Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma

Scientific Reports
Glaucoma is the leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form globally and has been linked to mitochondrial dysfunction and energy deficiency.
Yizhen Tang, Xuanqi Zhang, Xiaoxiao Chen, Jiayong Li, Minyue Xie, Qianru Wu, Yinghan Zhang, Chi-wai Do, Xinghuai Sun   +8 more
doaj   +1 more source

Uridine diphosphate-glucose/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation. [PDF]

J Clin Invest, 2021
Foster PS, Tay HL, Hogan SP.
europepmc   +1 more source

Nucleotides. Part XV. a synthesis of uridine-5′ pyrophosphate, a breakdown product of the coenzyme uridine-diphosphate-glucose

, 1952
Uridine.5’ pyrophosphate has been synthesized by condensing 2’:3’-iso-propylidene 5’-iodo-5’-deoxyuridine with silver tribenzyl pyrophosphate and subsequently removing the protecting groups. The product, isolated as its barium salt, is identical with the
Anand, N., Clark, V. M., Hall, R. H., Todd, A. R.   +3 more
core   +1 more source

Effects of galU Mutation on Pseudomonas syringae–Plant Interactions

Molecular Plant-Microbe Interactions, 2010
Bacterial galU coding for a uridine diphosphate-glucose pyrophosphorylase plays an important role in carbohydrates biosynthesis, including synthesis of lipopolysaccharides (LPS), membrane-derived oligosaccharides, and capsular polysaccharides.
Wen-Ling Deng, Yuan-Chun Lin, Rong-Hwa Lin, Chia-Fong Wei, Yi-Chiao Huang, Hwei-Ling Peng, Hsiou-Chen Huang   +6 more
doaj   +1 more source

Catalytic Promiscuity of O‑GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2‑Azido-2-deoxy-glucose

, 2016
O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes.
Tom Clark (3389027), Samy Cecioni (1697791), Ta-Wei Liu (771106), David Vocadlo (2996871), Wesley Zandberg (2249644), Matthew G. Alteen (3236664), Razieh Eskandari (2308522), Hong Yee Tan (3389024), Yanping Zhu (367304), David L. Shen (1682476)   +9 more
core   +1 more source