Results 71 to 80 of about 664,008 (165)

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, Volume 13, Issue 51, 14 September 2026.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy [PDF]

, 2001
BACKGROUNDEarly and accurate diagnosis of Crigler-Najjar syndrome, which causes prolonged unconjugated hyperbilirubinaemia in infancy, is important, as orthotopic liver transplantation is the definitive treatment.
M A Preece, McKiernan, P.J., Kelly, D.A., P J McKiernan, Kelly, Deirdre, B Burchell, Clarke, Douglas, Burchell, B, Lee, W. S., Beath, Susan, Baty, D, Clarke, D. J., Preece, M.A., Burchell, B., McKiernan, P. J., Lee, Way Seah, S V Beath, Clarke, DJ, D J Clarke, Clarke, D.J., Preece, Mary, Lee, WS, D Baty, W S Lee, Lee, W S, Beath, S.V., D A Kelly, Baty, D., Preece, M. A., Beath, S. V., McKiernan, Patrick, Kelly, D. A.   +31 more
core   +1 more source

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

mBio
Multidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health.
Larissa Dirr, Sven Cleeves, Isabel Ramón Roth, Linghui Li, Timm Fiebig, Thomas Ve, Susanne Häussler, Armin Braun, Mark von Itzstein, Jana I. Führing   +9 more
doaj   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Analysis of drug metabolic disorder using recombinant uridine diphosphate-glucuronosyltransferase. [PDF]

, 2002
Others学位授与機関：　滋賀医科大学　博士（医学）第388号　平成14年3月25日1) Effect of a conserved mutation in uridine diphosphate glucuronosyltransferase 1A1 and 1A6 on glucuronidation of a metabolite of flutamide. European Journal of Clinical Pharmacology.
伊藤, 誠紀
core   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, Volume 74, Issue S1, Page S58-S64, September 2026.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]

, 2013
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep, Munshi, T, Sanjib Bhakta (106475), Bhakta, S, Gupta, A, Gibbons, S., Simon Gibbons (391868), Nicholas H. Keep (392673), Antima Gupta, Keep, Nicholas H., Gibbons, Simon, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Juan David Guzman (392672), Gibbons, S, Simon Gibbons, Dimitrios Evangelopoulos (392671), Tulika Munshi (392669), Antima Gupta (392670), Juan David Guzman, Evangelopoulos, D, Guzman, Juan David, Gupta, Antima, Dimitrios Evangelopoulos, Munshi, Tulika, Sanjib Bhakta, Keep, NH, Guzman, Juan D., Guzman, JD, Tulika Munshi   +29 more
core   +1 more source

Theoretical pKa prediction of the α-phosphate moiety of uridine 5′-diphosphate-GlcNAc

, 2017
The pKa value of the α-phosphate moiety of uridine 5'-diphosphate-GlcNAc (UDP-GlcNAc) has been successfully calculated using density functional theory methods in conjunction with the Polarizable Continuum Models. Theoretical methods were benchmarked over
Bhavani Prasad Vipperla (20126115), Haibo Yu (19586578), Thomas Griffiths (19585060), Xingyong Wang (20124462)   +3 more
core   +1 more source