Results 51 to 60 of about 22,755 (222)

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

eLife, 2021
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation ...
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen   +12 more
doaj   +1 more source

Galactose Epimerase Deficiency: Expanding the Phenotype [PDF]

, 2017
Galactose epimerase deficiency is an inborn error of metabolism due to uridine diphosphate-galactose-4'-epimerase (GALE) deficiency. We report the clinical presentation, genetic and biochemical studies in two siblings with generalized GALE deficiency ...
A Alano, DJ Lefeber, IB Sardharwalla, J Charlwood, J Wasilenko, JB Holton, JB Holton, JH Walter, KK Openo, L Sturiale, M Sarkar, MJ Henderson, R Gitzelmann, SS Sparrow, TM Wohlers   +14 more
core   +1 more source

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari, A AntonySunil, A Makino, A Turano, Anindita Das, AO Phillips, B Ashokkumar, B Dutta, B Sihag, BR Chamberlain, CME Tallaksen, Daniel Zehnder, ED Schleicher, Fang Zhang, G Gastaldi, GLJ Page, Guerman Molostvov, H Lum, H Smithline, HM Said, I Hubatsch, J Rieck, James R. Larkin, JC Reidling, JC Reidling, JC Reidling, JD Eudy, KA Robinson, Lisa Godfrey, MJ Boulware, MJ Ryan, MW Pfaffl, N Rabbani, N Rabbani, N Takahashi, N Tasevska, Naila Rabbani, Paul J. Thornalley, PJ Thornalley, R Babaei-Jadidi, S Sander, SM Nabokina, VS Subramanian   +42 more
core   +5 more sources

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie, Seye, Cheik I., Weisman, Gary A., Woods, Lucas T.   +3 more
core   +1 more source

Uridine Diphosphate-4-Keto-Glucose, an Intermediate in the Uridine Diphosphate-Galactose-4-Epimerase Reaction [PDF]

Proceedings of the National Academy of Sciences, 1971
When UDP-galactose 4-epimerase (EC 5.1.3.2) from Escherichia coli is incubated with UDP-galactose, then reduced with NaB 3 H 4 , label is found in UDP-glucose and UDP-galactose.
U S, Maitra, H, Ankel
openaire   +2 more sources

Selective Detoxification of Phenols by Pichia pastoris and Arabidopsis thaliana Heterologously Expressing the PtUGT72B1 from Populus trichocarpa. [PDF]

PLoS ONE, 2013
Phenols are present in the environment and commonly in contact with humans and animals because of their wide applications in many industries. In a previous study, we reported that uridine diphosphate-glucose-dependent glucosyltransferase PtUGT72B1 from ...
Zhi-Sheng Xu, Ya-Qiu Lin, Jing Xu, Bo Zhu, Wei Zhao, Ri-He Peng, Quan-Hong Yao   +6 more
doaj   +1 more source

Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler–Najjar syndromes [PDF]

, 2006
We describe the molecular study in a cohort of 120 Portuguese patients with the clinical diagnosis of Gilbert syndrome and in one with the diagnosis of Crigler–Najjar syndrome type II, as well as a prenatal diagnosis of Crigler–Najjar syndrome type I ...
Barbot, José, Bauerle, Roswitha, Cancela, Eugénia, Carvalho, João, Costa, Elísio, Costa, Miguel, Freitas, Teresa, Martins, Marcia, Santos, Rosário, Santos-Silva, Ermelinda, Saraiva, Jorge, Vieira, Emília   +11 more
core   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae

mBio
In all kingdoms of life, the enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) occupies a central role in metabolism, as its reaction product uridine diphosphate-glucose (UDP-Glc) is involved in various crucial cellular processes.
Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing   +6 more
doaj   +1 more source

Overexpression of DoUGP Enhanced Biomass and Stress Tolerance by Promoting Polysaccharide Accumulation in Dendrobium officinale

Frontiers in Plant Science, 2020
Uridine diphosphate glucose pyrophosphorylase (UDP-glucose pyrophosphorylase, UGPase), as one of the key enzymes in polysaccharide synthesis, plays important roles in the growth and development of plants.
Ji Chen, Li Wang, Huan Liang, Xiaowan Jin, Jian Wan, Fan Liu, Ke Zhao, Jin Huang, Mengliang Tian   +8 more
doaj   +1 more source