Results 31 to 40 of about 664,008 (165)

Rhamnose-Containing Compounds: Biosynthesis and Applications

Molecules, 2022
Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy.
Siqiang Li, Fujia Chen, Yun Li, Lizhen Wang, Hongyan Li, Guofeng Gu, Enzhong Li   +6 more
doaj   +1 more source

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

BMC Biology, 2019
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella, Lorela Ciraku, Mauricio J. Reginato   +2 more
doaj   +1 more source

HISTOCHEMICAL DEMONSTRATION OF URIDINE DIPHOSPHATE GLUCOSE-GLYCOGEN TRANSFERASE IN ANIMAL TISSUES

, 1961
Polysaccharide was histochemically synthesized in muscle fibers and other tissue cells by using uridine diphosphate glucose as substrate. By revising the method previously described in light of new biochemical and histochemical findings more ...
TADAO TAKEUCHI, GEORGE G. GLENNER
core   +1 more source

Biocatalytic Synthesis of Calycosin-7-O-β-D-Glucoside with Uridine Diphosphate–Glucose Regeneration System

, 2020
Calycosin-7-O-β-D-glucoside (Cy7G) is one of the principal components of Radix astragali. This isoflavonoid glucoside is regarded as an indicator to assess the quality of R. astragali and exhibits diverse pharmacological activities.
Juankun Zhang, Longhai Dai, Jian Min, Xuejing Yu, Yumei Hu, Yingying Qu, Xiao Zhang   +6 more
core   +1 more source

Antiviral activity of uridine 5'-diphosphate glucose analogues against some enveloped viruses in cell culture

, 2021
Twenty five analogues of uridine 5'-diphosphate glucose were screened against herpes simplex type 2, vaccinia virus, Sinbus virus and African swine fever virus.
Heras, F. G. de las, Vilas, Pilar, Pérez, Sara, García Gancedo, Angel, Pérez, C., Gil-Fernández, Carmen   +5 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae

mBio
In all kingdoms of life, the enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) occupies a central role in metabolism, as its reaction product uridine diphosphate-glucose (UDP-Glc) is involved in various crucial cellular processes.
Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing   +6 more
doaj   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice [PDF]

, 2013
Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also display fasting hypoglycaemia despite decreased insulin levels, which suggested that hepatic ...
Bastie, Claire C., Kurland, Irwin J., Elena Tarabra, Gustavo Palacios, Jeffrey E Pessin, Yang Yingjuan, Bastie Claire C., Tarabra, Elena, Gong-She Yang (490794), Claire C. Bastie (187271), Palacios Gustavo, Yingjuan Yang (490792), Irwin J. Kurland (177409), Claire C Bastie, Yingjuan Yang, Yang Gong-She, Yang, Gong-She, Irwin J Kurland, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Pessin Jeffrey E., Jeffrey E. Pessin (187274), Vaitheesvaran Bhavapriya, Yang, Yingjuan, Bhavapriya Vaitheesvaran (177385), Elena Tarabra (490793), Tarabra Elena, Bhavapriya Vaitheesvaran, Gustavo Palacios (67191), Kurland Irwin J., Gong-She Yang, Pessin, Jeffrey E.   +31 more
core   +2 more sources