Results 11 to 20 of about 12,547 (216)

Uridine diphosphate glucose confers oxidative stress tolerance in microalgae [PDF]

BMC Plant Biology
Background Microalgae, as major primary producers on Earth, are constantly exposed to oxidative stresses from various natural environments. These oxidative stresses often seriously threaten the productivity and species composition of microalgae. However,
Ruihao Zhang, Tengfei Xiao, Baohua Zhu, Chengxiang Kan, Xing Chen, Zihao Cao, Yan Zhao, Yun Li, Guanpin Yang, Kehou Pan   +9 more
doaj   +3 more sources

Uridine Diphosphate Glucose (UDP-G) Activates Oxidative Stress and Respiratory Burst in Isolated Neutrophils [PDF]

Pharmaceuticals, 2023
The extracellular purinergic agonist uridine diphosphate glucose (UDP-G) activates chemotaxis of human neutrophils (PMN) and the recruitment of PMN at the lung level, via P2Y14 purinergic receptor signaling.
Fabiana Lairion, Claudio Carbia, Iris Maribel Chiesa, Christian Saporito-Magriña, Natalia Borda, Alberto Lazarowski, Marisa Gabriela Repetto   +6 more
doaj   +4 more sources

Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients [PDF]

International Journal of Molecular Sciences, 2023
We previously reported that glucokinase undergoes ubiquitination and subsequent degradation, a process mediated by cereblon, particularly in the presence of uridine diphosphate glucose (UDP-glucose). In this context, we hereby present evidence showcasing
Jaeyong Cho, Yukio Horikawa, Kazuyoshi Hosomichi   +2 more
exaly   +3 more sources

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +2 more sources

Cloning cDNA and functional characterization of UDP-glucose pyrophosphorylase in Dendrobium officinale

Biologia Plantarum, 2017
Dendrobium officinale is a traditional Chinese medicinal herb that produces promising bioactive polysaccharides. However, the biosynthetic pathway of polysaccharides in this herb remains to be elucidated. The uridine diphosphate glucose pyrophosphorylase
R.-L. Wan, J. Sun, T. He, Y.-D. Hu, Y. Zhao, Y. Wu, Z. Chun   +6 more
doaj   +2 more sources

Genomic-Wide Identification and Characterization of the Uridine Diphosphate Glycosyltransferase Family in Eucommia ulmoides Oliver

Plants, 2021
Eucommia ulmoides Oliver is a woody plant with great economic and medicinal value. Its dried bark has a long history of use as a traditional medicinal material in East Asia, which led to many glycosides, such as aucubin, geniposide, hyperoside ...
Dan Ouyang, Lan-Chun Wang, Ting Tang, Hong Feng   +3 more
doaj   +2 more sources

YvcK, a protein required for cell wall integrity and optimal carbon source utilization, binds uridine diphosphate-sugars

Scientific Reports, 2017
In Bacillus subtilis, Listeria monocytogenes and in two Mycobacteria, it was previously shown that yvcK is a gene required for normal cell shape, for optimal carbon source utilization and for virulence of pathogenic bacteria.
Elodie Foulquier, Anne Galinier
doaj   +2 more sources

UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor [PDF]

Communications Biology
P2Y14 receptors respond to uracil-diphosphate-hexose conjugates, yet how this receptor selectively recognizes both uracil-nucleotides and hexose moieties of diverse agonists remains unclear.
Jonathan F. Fay, Joseph Kousouros, Zhan-Guo Gao, Matteo Pavan, Paola Oliva, Asmita Pramanik, Clayton Meyer, Siva Hariprasad Kurma, Wen Xu, Brian Krumm, Kenneth A. Jacobson   +10 more
doaj   +2 more sources

Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases [PDF]

Frontiers in Physiology
Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a concentration higher than the other nucleosides. As a simple metabolite, uridine plays a pivotal role in various biological processes. In addition to nucleic acid synthesis,
Yueyuan Yang, Yahong Ye, Yingfeng Deng, Ling Gao   +3 more
doaj   +2 more sources

Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae

mBio
In all kingdoms of life, the enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) occupies a central role in metabolism, as its reaction product uridine diphosphate-glucose (UDP-Glc) is involved in various crucial cellular processes.
Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing   +6 more
doaj   +2 more sources