Results 41 to 50 of about 12,547 (216)

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Tenhaken, Raimund, Klinghammer, Michaela
core   +1 more source

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

BMC Biology, 2019
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella, Lorela Ciraku, Mauricio J. Reginato   +2 more
doaj   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source

Uridine Diphosphate-4-Keto-Glucose, an Intermediate in the Uridine Diphosphate-Galactose-4-Epimerase Reaction [PDF]

Proceedings of the National Academy of Sciences, 1971
When UDP-galactose 4-epimerase (EC 5.1.3.2) from Escherichia coli is incubated with UDP-galactose, then reduced with NaB 3 H 4 , label is found in UDP-glucose and UDP-galactose.
U S, Maitra, H, Ankel
openaire   +2 more sources

Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis [PDF]

, 2009
An important question in Systems Biology is the design of experiments that enable discrimination between two (or more) competing chemical pathway models or biological mechanisms.
Roper, D., D. Bearup, Chappell, M.J., Evans, N.D., N.D. Evans, Evans, Neil D., Hattersley, J.G., Bugg, T., M.J. Chappell, Dowson, Christopher G., D. Roper, Pérez-Velázquez, J., J.G. Hattersley, T. Bugg, Chappell, M. J. (Michael J.), Bearup, Daniel, Bearup, Daniel James, Dowson, C., Hattersley, John G., J. Pérez-Velázquez, Perez-Velazque, J., Roper, David I., Bugg, Tim, C. Dowson   +23 more
core   +1 more source

HISTOCHEMICAL DEMONSTRATION OF URIDINE DIPHOSPHATE GLUCOSE-GLYCOGEN TRANSFERASE IN ANIMAL TISSUES

, 1961
Polysaccharide was histochemically synthesized in muscle fibers and other tissue cells by using uridine diphosphate glucose as substrate. By revising the method previously described in light of new biochemical and histochemical findings more ...
TADAO TAKEUCHI, GEORGE G. GLENNER
core   +1 more source

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

eLife, 2021
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation ...
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen   +12 more
doaj   +1 more source

Functional analysis of the Lactococcus lactis galU and galE genes and their impact on sugar nucleotide and exopolysaccharide biosynthesis

, 2001
We studied the UDP-glucose pyrophosphorylase (galU) and UDP-galactose epimerase (galE) genes of Lactococcus lactis MG1363 to investigate their involvement in biosynthesis of UDP-glucose and UDP-galactose, which are precursors of glucose- and galactose ...
Boels, I.C., Vos, W.M., de, Kleerebezem, M., Ramos, A., de Vos, W.M.   +4 more
core   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Selective Detoxification of Phenols by Pichia pastoris and Arabidopsis thaliana Heterologously Expressing the PtUGT72B1 from Populus trichocarpa. [PDF]

PLoS ONE, 2013
Phenols are present in the environment and commonly in contact with humans and animals because of their wide applications in many industries. In a previous study, we reported that uridine diphosphate-glucose-dependent glucosyltransferase PtUGT72B1 from ...
Zhi-Sheng Xu, Ya-Qiu Lin, Jing Xu, Bo Zhu, Wei Zhao, Ri-He Peng, Quan-Hong Yao   +6 more
doaj   +1 more source