Results 241 to 250 of about 120,368 (286)

Effects of uridine triphosphate on skinned skeletal muscle fibers of the rat

Canadian Journal of Physiology and Pharmacology, 1995
Chemically skinned muscle fibers from rat extensor digitorum longus muscle were used to study the effects of uridine triphosphate (UTP) on Ca2+uptake and release by the sarcoplasmic reticulum (SR) and on Ca2+-activated tensions. Total replacement (2.5 mM) of adenosine triphosphate (ATP) with UTP (i) increased submaximal Ca2+-induced tension (pCa 6.2–5 ...
Cristiano G Ponte, M.P. Catinot, Rosane Vianna-Jorge, Yvonne Mounier, Guilherme Suarez-Kurtz   +4 more
openaire   +4 more sources

Effect of uridine diphosphoglucose on levels of 5-phosphoribosyl pyrophosphate and uridine triphosphate in murine tissues.

Pharmaceutical research, 1989
The purpose of the present investigation was to determine whether a single bolus intravenous injection (2000 mg/kg) of uridine diphosphoglucose (UDPG) could affect levels of PRPP in a transplanted mammary adenocarcinoma and in liver of CD8FI mice. Six hours following a single intravenous injection of UDPG, 2000 mg/kg, tumor PRPP was lowered to 80 pmol ...
Joseph R. Colofiore, Robert C. Sawyer, M E Balis, Daniel S. Martin   +3 more
openaire   +4 more sources

Consequences of uridine triphosphate deficiency in liver and hepatoma cells [PDF]

, 1975
A sequence of events caused by an acute injury leading to cellular death and subsequently to necrosis can be analysed best if the following prerequisites are given: 1. The injurious agent or the toxin under study causes a selective primary lesion rather than a variety of initial effects. 2.
D. Keppler
openaire   +2 more sources

Uridine triphosphate and RNA synthesis during diabetes-induced renal growth

American Journal of Physiology-Endocrinology and Metabolism, 1980
UTP, CTP, and RNA synthesis were studied in the renal cortex of diabetic and control rats in vivo. The incorporation of UTP into RNA (nmol/h DNA) was used as estimate of RNA synthesis rate. Two to three days after streptozotocin injection, UTP and CTP ppol size and orotate incorporation into UTP and RNA were greater in diabetic animals than in controls.
N. W. Levin, K. K. Venkatachalam, C. P. Verghese, P. Cortes, Francis Dumler, Arthur H. Rubenstein   +5 more
openaire   +4 more sources

Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle

Metabolism, 1979
The influence of diabetes and starvation on uracil nucleotide metabolism in muscle was studied. It was found that the uridine triphosphate (UTP) content of heart and diaphragm muscle was decreased in fasted and streptozotocin-diabetic rats and that insulin treatment of diabetic animals restored the UTP concentration to normal levels. The ATP content of
Ella S. Haugaard, Barry J. Gertz
openaire   +4 more sources

Pathway Optimization and Uridine 5'-Triphosphate Regeneration for Enhancing Lacto-N-Tetraose Biosynthesis in Engineered Escherichia coli.

Journal of Agricultural and Food Chemistry, 2022
Recently, human milk oligosaccharides (HMOs) have attracted increasing attention and display great commercial importance, especially for the infant formula industry.
Zeyu Li, Yingying Zhu, Pan Zhang, Wenli Zhang, W. Mu   +4 more
semanticscholar   +1 more source

Liver uridine triphosphate after partial hepatectomy

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
Richard Abrams, Roger L.P. Adams, Irving Lieberman, Peter Ove   +3 more
openaire   +4 more sources

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

Journal of Medicinal Chemistry, 2016
JNJ-54257099 (9) is a novel cyclic phosphate ester derivative that belongs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which are known as inhibitors of the HCV NS5B RNA-dependent RNA polymerase (RdRp).
T. Jonckers, A. Tahri, L. Vijgen, J. Berke, S. Lachau-Durand, B. Stoops, J. Snoeys, L. Leclercq, L. Tambuyzer, Tse-i Lin, K. Simmen, P. Raboisson   +11 more
semanticscholar   +1 more source

5′-Mercuri-uridine triphosphate as a substrate for transcription

Analytical Biochemistry, 1982
Abstract The use of mercurated nucleotides permitting a specific isolation of newly synthesized RNA has proven useful in the study of in vitro transcription. However, there has been little direct investigation of their effect on the polymerization reaction.
David W. Miller, Sarah C. R. Elgin
openaire   +3 more sources

ENZYMATIC AMINATION OF URIDINE TRIPHOSPHATE TO CYTIDINE TRIPHOSPHATE¹

Journal of the American Chemical Society, 1955
I. Lieberman
openaire   +3 more sources