Results 251 to 260 of about 120,368 (286)

Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate.

Biochemistry, 1997
Deoxycytidine kinase is the rate-limiting process in the activation for several clinically important antitumor agents. Previous studies have focused on deoxycytidine (dCyd) and adenosine triphosphate (ATP) as substrates for this enzyme. In view of recent
T. Hughes, T. Hahn, K. K. Reynolds, D. Shewach   +3 more
semanticscholar   +1 more source

Validity and Safety of Sputum Induction by Inhaled Uridine 5 ′ -Triphosphate [PDF]

American Journal of Respiratory and Critical Care Medicine, 2001
Inhalation of hypertonic saline during sputum induction causes bronchoconstriction. We studied the validity and safety of sputum induction by uridine 5'-triphosphate (UTP). Sputum was induced by a 5-min inhalation of hypertonic saline (3%) on Day 1 and UTP (5 mg/ml in 0.9% saline) on Days 8 and 15 in 16 healthy subjects and 16 patients with mild-to ...
Kazutetsu Aoshiba, Kiyoshi Takeyama, Mitsuko Kondo, Hisatoshi Kuroda, Junko Nakata, Jun Tamaoki, Atsushi Nagai   +6 more
openaire   +2 more sources

Constriction of the smooth muscle of rat tail and femoral arteries and dog saphenous vein is induced by uridine triphosphate via 'pyrimidinoceptors', and by adenosine triphosphate via P2x purinoceptors.

Blood & Vessel, 1990
Adenosine triphosphate (ATP) and uridine triphosphate (UTP) receptors were studied by comparing the contractile responses to UTP with those to ATP in the rat tail and femoral arteries and dog saphenous vein, after endothelium removal confirmed by ...
B. Saïag, D. Milon, H. Allain, B. Rault, J. J. van den Driessche   +4 more
semanticscholar   +1 more source

Mechanism of Ribonucleic Acid Polymerase Action. Effect of Nearest Neighbors on Competition between Uridine Triphosphate and Uridine Triphosphate Analogs for Incorporation into Ribonucleic Acid

Biochemistry, 1967
Paul Berg, Saul Slapikoff
openaire   +4 more sources

Force development with inosine triphosphate and uridine triphosphate in chemically skinned vascular smooth muscle

Life Sciences, 1996
The contraction of vascular smooth muscle is thought to be regulated by reversible phosphorylation of the 20,000 dalton light chains of myosin, catalyzed by myosin light chain kinase that is dependent on calcium and calmodulin. With phosphorylation, there is a coincident increase in the actin-activated myosin NTPase activity, cross bridge interaction ...
Michelle Mattie Geremia, F.P.J. Diecke, F.P.J. Diecke   +2 more
openaire   +3 more sources

Differential regulations between adenosine triphosphate (ATP)- and uridine triphosphate-induced Cl(-) secretion in bovine tracheal epithelium. Direct stimulation of P1-like receptor by ATP.

American Journal of Respiratory Cell and Molecular Biology, 2001
Adenosine 5'-triphosphate (ATP) stimulates airway epithelial Cl(-) secretion in a complicated manner. We examined the difference between ATP- and uridine 5'-triphosphate (UTP)-induced responses of short-circuit current (Isc) in bovine tracheal epithelium
S. Kanoh, M. Kondo, J. Tamaoki, H. Kobayashi, K. Motoyoshi, A. Nagai   +5 more
semanticscholar   +1 more source

Inhibition of uridine‐cytidine kinase by 5‐azacytidine 5′‐triphosphate

Medical and Pediatric Oncology, 1976
Abstract5‐Azacytidine 5′‐triphosphate (5‐aza‐CTP) inhibited the phosphorylation of uridine, cytidine, and 5‐azacytidine (5‐aza‐C) in a reaction catalyzed by uridine‐cytidine kinase. The inhibition appeared to be competitive with respect to the adenosine 5′‐triphosphate and noncompetitive with respect to nucleoside substrates.
Richard L. Momparler, Thomas Lee
openaire   +3 more sources

Differential effects of apical and basolateral uridine triphosphate on intestinal epithelial chloride secretion.

American Journal of Physiology - Cell Physiology, 2001
Our goal was to examine the sidedness of effects of the purinergic agonist, uridine 5'-triphosphate (UTP), on Cl(-) secretion in intestinal epithelial cells. We hypothesized that UTP might exert both stimulatory and inhibitory effects.
J. Smitham, Kim E. Barrett
semanticscholar   +1 more source

Ionic interaction of amiloride and uridine 5′-triphosphate in nebulizer solutions

Journal of Pharmaceutical Sciences, 2004
Combination therapy using nebulized amiloride hydrochloride and uridine-5'-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations.
Ronald J. Pettis, M Kazantseva, Michael R. Knowles, Anthony J. Hickey, Kenneth N. Olivier   +4 more
openaire   +3 more sources

Mechanisms and Therapeutic Actions of Uridine Triphosphate in the Lung

1995
The lung’s primary function is gas exchange. However, during the process of respiration the lung is exposed to large quantities of potentially toxic and infectious agents from the ambient environment. To meet this challenge, the lung has evolved efficient ways of defending itself from such insults.
M. J. Stutts, R. C. Boucher, W. Bennett, M. R. Knowles, Kenneth N. Olivier, S. J. Mason   +5 more
openaire   +2 more sources