Results 181 to 190 of about 102,449 (341)

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

open access: yesAndrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin   +11 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

open access: yesAndrology, EarlyView.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu   +18 more
wiley   +1 more source

Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs

open access: yesArtificial Organs, EarlyView.
This pig model of simultaneous perfusion of paired kidneys in normothermia suggests that intra‐individual variation is relatively low, enabling one kidney to be employed as a reliable comparator of the other kidney for assessing treatments before kidney transplantation.
Margaux Navez   +12 more
wiley   +1 more source

Dorsal Genital Nerve Stimulation as an Adjunctive Therapy to Control Neurogenic Detrusor Overactivity After Spinal Cord Injury

open access: yesArtificial Organs, EarlyView.
People with spinal cord injury (SCI) experience bladder overactivity, which can cause incontinence. Dorsal genital nerve stimulation (DGNS) can suppress overactivity, providing a longer duration to reach a toilet. People with SCI trialed home‐based DGNS for 8 weeks. DGNS was effective in the laboratory, and participants found home‐based DGNS acceptable.
Sean Doherty   +4 more
wiley   +1 more source

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