Results 1 to 10 of about 24,100,914 (308)

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science
Antibody‐drug conjugates (ADCs) emerge as a potent cancer therapeutic strategy by enabling precise antigen recognition and efficient intracellular delivery of cytotoxic payloads. In this study, 7‐ethyl‐9‐fluorocamptothecin (A2), a camptothecin derivative,
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
doaj   +1 more source

The clinical efficacy of novel semirigid ureteroscopy with a vacuum suction device for treatment of >10 mm upper ureteral stones and impacted calculus: implications for clinical practice

Frontiers in Surgery
ObjectiveThe novel semirigid ureteroscopy with a vacuum suction device has been increasing in the treatment of urinary stones recently. This study aimed to evaluate its clinical efficacy for treating >10 mm upper ureteral stones and impacted calculus ...
Longhui Lai, Longhui Lai, Yuanfeng Zhang, Yuanfeng Zhang, Yingru Wang, Enguang Yang, Guangrui Fan, Chaohu Chen, Kang Yao, Wenzhao Zhang, Wenzhao Zhang, Yongfei Liu, Yongfei Liu, Kai Zhu, Kai Zhu, Meixuan Ding, Meixuan Ding, Jinchun Xing, Zhiping Wang, Peide Bai, Tao Wang, Bin Chen, Jun Mi   +22 more
doaj   +1 more source

Studies on the clinical significance of nonesterified and total cholesterol in urine [PDF]

, 1981
Gas-liquid chromatographic determinations of nonesterified and total urinary cholesterol were performed in 137 normals, 264 patients with various internal diseases without evidence of neoplasias or diseases of the kidney or urinary tract, 497 patients ...
A. Pickel, A. Stadler, BA Vela, D Jüngst, D Jüngst, D. Jüngst, DE Comings, E Bloch, F. J. Marsx, H Sobotka, H Sobotka, H. J. Karl, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, J Bing, J Frick, J. Wallner, JA Belis, JC Sutherland, JG Zimmer, JW Eagen, M Bruger, M Bruger, M Spiteller-Friedmann, MM Burchell, MM Burchell, P Kerkhoven, S Klahr, SG Mendoza de, TM Chu, W Trappe, W. Eiermann   +35 more
core   +2 more sources

Current perspectives and trends on the role of mitochondria in renal ischemia-reperfusion injury from 2005 to 2024: a bibliometric analysis and literature review

Frontiers in Physiology
BackgroundRenal ischemia-reperfusion injury (RIRI) represents a leading cause of acute kidney injury (AKI). Mitochondria, serving as the central organelles for cellular energy metabolism and signal transduction, play a pivotal role in the pathogenesis of
Rui Yan, Rui Yan, Rui Yan, Yalong Zhang, Yalong Zhang, Yalong Zhang, Zewen Li, Zewen Li, Zewen Li, Kunpeng Li, Kunpeng Li, Kunpeng Li, Jiangwei Man, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang, Li Yang   +17 more
doaj   +1 more source

Multifocal primary tumour with lesions in prostate gland and urinary bladder: clinical case [PDF]

, 2017
In some cases a combination of several malignant tumours in one person can be observed. In such case it is the multifocal primary tumour (MPT). The tumours combination in genitourinary system is rare phenomenon, including a rare combination of prostate ...
Budko, Hanna Yuriivna, Lyndin, Mykola Serhiiovych, Piddubnyi, Artem Mykhailovych, Romaniuk, Anatolii Mykolaiovych, Sikora, Vladyslav Volodymyrovych, Volkohon, Andrii Dmytrovych, Будко, Анна Юрьевна, Будко, Ганна Юріївна, Волкогон, Андрей Дмитриевич, Волкогон, Андрій Дмитрович, Линдін, Микола Сергійович, Лындин, Николай Сергеевич, Поддубный, Артем Михайлович, Піддубний, Артем Михайлович, Романюк, Анатолий Николаевич, Романюк, Анатолій Миколайович, Сикора, Владислав Владимирович, Сікора, Владислав Володимирович   +17 more
core   +1 more source

Pelvic vasectomy and its protective effects on rat testis function

Basic and Clinical Andrology
Background Vasectomy is a commonly used male contraceptive method, but the choice of surgical technique can influence long-term reproductive health outcomes.
Heng Yang, Yujun Chen, Xiaofeng Cheng, Jingxin Wu, Ruohui Huang, Biao Qian, Gongxian Wang   +6 more
doaj   +1 more source

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]

, 2017
Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G, Cusumano, Zachary T, Flores-Mireles, Ana L, Hultgren, Scott J, Takagi, Enzo, Xu, Wei   +5 more
core   +3 more sources

Impacts of chronic stress on urinary bladder function & recovery through modification of PACAP signaling [PDF]

, 2016
Stress can cause or contribute to bladder dysfunction though specific effects remain unclear. Individuals with interstitial cystitis (IC)/bladder pain syndrome (BPS) experience increased symptom severity with stress, including pain and increased urgency ...
Mathews, Morgan E
core   +1 more source

A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer

Journal of Nanobiotechnology
Background Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity.
Yuanfeng Zhang , Enguang Yang, Xinyu Zhang , Yibo Shi , Guangrui Fan, Yuhan Wang, Junqiang Tian, Hanzhang Wang, Zhilong Dong, Yingru Wang, Liang Cheng, Zhiwen Zhao, Yonghai Zhang, Baodui Wang, Zhiping Wang   +14 more
doaj   +1 more source

AGBL2 promotes renal cell carcinoma cells proliferation and migration via α-tubulin detyrosination

Heliyon
Background: AGBL2's role in tumorigenesis and cancer progression has been reported in several cancer studies, and it is closely associated with α-tubulin detyrosination.
Wei Liu, Yifei Zhang, Yechen Nie, Yifu Liu, Zhongqi Li, Zhicheng Zhang, Binbin Gong, Ming Ma   +7 more
doaj   +1 more source