Results 31 to 40 of about 23,239,646 (389)

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +2 more sources

Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients

Frontiers in Medicine, 2022
BackgroundDiabetic kidney disease (DKD) is the primary cause of end-stage renal disease, raising a considerable burden worldwide. Recognizing novel biomarkers by metabolomics can shed light on new biochemical insight to benefit DKD diagnostics and ...
Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaoyi Wang, Xiaoyi Wang, Xiaoyi Wang, Xiaoyi Wang, Xiaoyi Wang, Xue Shao, Xue Shao, Xue Shao, Xue Shao, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cunqi Ye, Cunqi Ye, Cunqi Ye, Cunqi Ye, Cunqi Ye, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +37 more
doaj   +1 more source

Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]

, 2012
Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Antonia Vlahou, Ariela Benigni, B Jonsson, Bernd Mayer, C Delles, C Weyer, C Zoja, Carlamaria Zoja, CD Wenger, CL Oltman, CS Fox, D Theodorescu, Ferdinand H. Bahlmann, H Mischak, H Mischak, Harald Mischak, J Drube, J Toblli, JO Deguchi, Joachim Jankowski, Julie Klein, Justyna Siwy, K Voros, Karin Jandeleit-Dahm, M Hashemi, M Haubitz, N Ahmed, N Verzijl, ND Rawlings, P Zurbig, Paul Perco, PJ Talmud, PR Cutillas, R Rouse, Robert Stevens, S Andersen, S Wild, SA Varghese, Sophia Kossida, T Nakagawa, TW Kurtz, Wiliam Mullen, Y Benjamini, Y Igarashi   +43 more
core   +3 more sources

Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis

Frontiers in Immunology, 2022
Focal segmental glomerulosclerosis (FSGS) has an over 30% risk of recurrence after kidney transplantation (Ktx) and is associated with an extremely high risk of graft loss. However, mechanisms remain largely unclear.
Qixia Shen, Qixia Shen, Qixia Shen, Qixia Shen, Lisha Teng, Lisha Teng, Lisha Teng, Lisha Teng, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Luying Guo, Luying Guo, Luying Guo, Luying Guo, Feng Xu, Hongfeng Huang, Hongfeng Huang, Hongfeng Huang, Hongfeng Huang, Wenqing Xie, Wenqing Xie, Wenqing Xie, Wenqing Xie, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Ying Chen, Ying Chen, Ying Chen, Ying Chen, Junwen Wang, Youying Mao, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +42 more
doaj   +1 more source

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Golgiphagy: a novel selective autophagy to the fore

Cell & Bioscience
The Golgi apparatus is the central hub of the cellular endocrine pathway and plays a crucial role in processing, transporting, and sorting proteins and lipids.
Yifei Chen, Yihui Wu, Xianyan Tian, Genbao Shao, Qiong Lin, Aiqin Sun   +5 more
doaj   +1 more source

D-mannose: a promising support for acute urinary tract infections in women. A pilot study [PDF]

, 2016
Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D-mannose is a simple sugar; it seems able to hinder bacteria adhesion to the urothelium.
BENEDETTI PANICI, PIERLUIGI, BRACCHI, CARLOTTA, COLAGIOVANNI, VANESSA, DOMENICI, LAVINIA, GIORGINI, MARGHERITA, MONTI, Marco, MUZII, LUDOVICO   +6 more
core  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Loss of RNF41 promotes bladder cancer metastasis through increasing NUDC stability to enhance tubulin polymerization

Cell Death and Disease
Bladder cancer (BCa) is a representative of urological cancer with a high recurrence and metastasis is the leading cause of death from BCa. The underlying mechanism of BCa metastasis remains poorly defined.
Fuchun Zheng, Sheng Li, Situ Xiong, Zhongqi Li, Ruize Yuan, Zhipeng Wang, Hao Wan, Jiahao Liu, Qianxi Dong, Xiaoqiang Liu, Wan Pang, Haibo Xi, Bin Fu, Songhui Xu   +13 more
doaj   +1 more source

Systemic sclerosis complicated with renal thrombotic microangiopathy: a case report and literature review

BMC Nephrology, 2022
Background Systemic sclerosis (SSc) may overlap with other connective tissue diseases, which is named overlap syndrome. Scleroderma renal crisis (SRC) is a rare but severe complication of SSc.
Weiwei Kong, Yaomin Wang, Huiping Wang, Qin Zhou, Jianghua Chen, Fei Han   +5 more
doaj   +1 more source