Results 31 to 40 of about 547,544 (315)

PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses

Life Science Alliance
This study reveals that PTEN modulates bladder urothelial immunity by regulating Akt, NFκB, and FAK signaling, shaping susceptibility to urinary tract infection.
Aaron Simoni, M Skye Bochter, Sarah Linn-Peirano, Kristin Salamon, Brian Becknell, Hanna Cortado, Ashley R Jackson, Laura Schwartz, John David Spencer   +8 more
doaj   +1 more source

Prevalence and Predictors of Urinary Tract Infection and Severe Malaria Among Febrile Children Attending Makongoro Health Centre in Mwanza City, North-Western Tanzania. [PDF]

, 2012
In malaria endemic areas, fever has been used as an entry point for presumptive treatment of malaria. At present, the decrease in malaria transmission in Africa implies an increase in febrile illnesses related to other causes among underfives.
Mazigo, Humphrey D, Bahati P Msaki, Msaki, Bahati P, Morona, Domenica, Stephen E Mshana, Adolfina Hokororo, Hokororo, Adolfina, Domenica Morona, Mshana, Stephen E, Humphrey D Mazigo   +9 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

Cell Reports
Summary: Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) shapes
Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R. Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spencer   +16 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Urinary tract infections

Current Opinion in Infectious Diseases, 1989
Abstract Urinary tract infections (UTI) are among the most common bacterial infections experienced by humans. On a worldwide basis, Harding and Ronald have estimated that 150 million UTIs occur annually, resulting in an estimated 6 billion dollars in health care costs.
openaire   +6 more sources

Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling

iScience
Summary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz, Kristin Salamon, Aaron Simoni, Israel Cotzomi-Ortega, Yuriko Sanchez-Zamora, Sarah Linn-Peirano, Preeti John, Juan de Dios Ruiz-Rosado, Ashley R. Jackson, Xin Wang, John David Spencer   +10 more
doaj   +1 more source

Urinary tract infections in the community [PDF]

, 2014
Urinary tract infections (UTIs) are defined as significant bacteriuria in the setting of symptoms of cystitis/pyelonephritis. Urine dipstick is diagnostic in most cases.
Bonnici, Jason J.
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

The cost-benefit analysis of hazardous medical waste: A case study of a hospital

Journal of Environmental Science
This study aimed to identify safe disposal methods for hazardous medical waste generated by healthcare institutions, particularly government hospitals, and to assess its impact on public health and the environment using a cost-benefit analysis .
elshimaa Abdelaziz
doaj   +1 more source