Results 61 to 70 of about 75,327 (314)

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar, Antonio Moschetta, Benedict Yan, Celestial T. Yap, Ee Hong Tan, Hwee Kee Tay, Jingli Zhuo, Lalchhandami Tochhawng, Manikandan Jayapal, Manuel Salto-Tellez, Shing Chuan Hooi, Shiuan Koh, Sutherland K. Maciver, Yaw Chong Goh, Yaw Chyn Lim   +14 more
core   +6 more sources

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes

Journal of Cell Biology, 1990
Receptor-bound urokinase-type plasminogen activator (uPA) remains associated to the surface of human monocytes for many hours. Monocytes induced to migrate in a chemotactic gradient of f-Met-Leu-Phe rapidly polarize their uPA receptors to the leading ...
A. Estreicher, Judith Miihlhauser, J. Carpentier, L. Orci, Jean-Dominique Vassalli   +4 more
semanticscholar   +1 more source

Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer. [PDF]

PLoS ONE, 2013
BACKGROUND: Colorectal cancer (CRC) is the second most common cause of death from cancer in both men and women in the majority of developed countries. Molecular tests of blood could potentially provide this ideal screening tool. AIM: Our objective was to
Luis Bujanda, Cristina Sarasqueta, Angel Cosme, Elizabeth Hijona, José M Enríquez-Navascués, Carlos Placer, Eloisa Villarreal, Marta Herreros-Villanueva, María D Giraldez, Meritxell Gironella, Francesc Balaguer, Antoni Castells   +11 more
doaj   +1 more source

The search for the ideal thrombolytic agent [PDF]

Since streptokinase and urokinase became available for clinical use, numerous attempts have been made to improve these useful thrombolytic agents.
Banyai, Barlow, Barlow, Been, Bernik, Bode, Bode, Brockway, Brogden, Carlin, Chazov, Chazov, Collen, Dodd, Dupe, Earnshau, Green, Gross, Gurewich, Günzler, Haber, Heyneker, Holeman, Holmes, Holvoet, Hoylaerts, Hui, Iga, Innertield, Johnson, Kagitani, Kakkar, Koide, Lawn, Lijnen, MacDonald, Maksimenko, Maksimenko, Maksimenko, Marbet, Marc Verstraete, Marder, Marder, Marshall, McClintock, Miillertz, Nakayama, Pannell, Papisov, Pennica, Petersen, Prandini, Prowse, Rajagopalan, Rajagopalan, Ranby, Reddy, Rijken, Rijken, Rijken, Rijken, Robbins, Sawyer, Seegers, Sekiguchi, Sherry, Sherry, Smith, Smith, Sottrup-Jensen, Spann, Stump, Summaria, Summaria, Sunimaria, Torchilin, Torchilin, Torchilin, Torchilin, Torchilin, Tsukada, van Zonnevejd, van Zonneveld, van Zonneveld, van Zonneveld, van Zonneveld, Verstraete, Vetterlein, Vitetta, Wallen, Wiman, Wohl, Wohl, Wun, Zamarron   +94 more
core   +1 more source

Binding of Human Urokinase Type Plasminogen Activator and Plasminogen to Borrelia Species [PDF]

Journal of Infectious Diseases, 1996
Borrelia burgdorferi binds human urokinase plasminogen activator (uPA), which cleaves plasminogen (Pgn) to plasmin. The ability of other Borrelia species to bind uPA, Pgn, or both was investigated. Borrelia coriacae, Borrelia garinii, Borrelia parkeri, Borrelia anserina, and Borrelia turicatae were compared with infectious and noninfectious B ...
Bilaal McCloud, Mark S. Klempner, Richard Noring, Mark P. Epstein, Rick A. Rogers   +4 more
openaire   +3 more sources

Myosin Light Chain Kinase Functions Downstream of Ras/ERK to Promote Migration of Urokinase-Type Plasminogen Activator-Stimulated Cells in an Integrin-Selective Manner

Journal of Cell Biology, 1999
Urokinase-type plasminogen activator (uPA) activates the mitogen activated protein (MAP) kinases, extracellular signal-regulated kinase (ERK) 1 and 2, in diverse cell types.
Diem H. D. Nguyen, A. Catling, D. Webb, M. Sanković, L. Walker, A. Somlyo, M. J. Weber, S. Gonias   +7 more
semanticscholar   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K., Kitts P.A., Kos J., Kotzsch M., Lah T.T., Magdolen U., Possee R.D., Rabbani S.A., Reuning U., Stetler-Stevenson W.G., Szpaderska A.M., Thomas C.J.   +11 more
core   +2 more sources

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates*

Journal of Biological Chemistry, 2000
Membrane-type serine protease 1 (MT-SP1) was recently cloned, and we now report its biochemical characterization. MT-SP1 is predicted to be a type II transmembrane protein with an extracellular protease domain.
T. Takeuchi, Jennifer L. Harris, Wei Huang, Kelly W. Yan, S. Coughlin, C. Craik   +5 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu, Lillian Tung, Issam Atallah, Changli Wei, Melody Cobleigh, Ruta Rao, Steven B. Feinstein, Lydia Usha, Kathrin Banach, Jochen Reiser, Tochukwu M. Okwuosa   +10 more
doaj   +1 more source