Results 61 to 70 of about 167,619 (306)
The search for the ideal thrombolytic agent [PDF]
Since streptokinase and urokinase became available for clinical use, numerous attempts have been made to improve these useful thrombolytic agents.
Verstraete, Marc
core +1 more source
Scientific Reports, 2017 Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation.
Kamlesh K. Gupta +4 more
doaj +1 more source
Urokinase-type plasminogen activator: a new target for male contraception?
Asian Journal of Andrology, 2015 Urokinase-type plasminogen activator (uPA) is closely related to male reproduction. With the aim of investigating the possibility for uPA as a potential contraceptive target, in the present work, Kunming male mice were immunized by human uPA subcutaneous
Ying Qin +5 more
doaj +1 more source
Advanced Science, EarlyView.CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan +9 more
wiley +1 more source
Myosin as cofactor and substrate in fibrinolysis [PDF]
, 1997 Myosin accelerates plasminogen activation by tissue-type plasminogen activator (tPA), and is degraded extensively by plasmin. Myosin binds both tPA and plasminogen, and enhances activation of des1-77-plasminogen by tPA but not by urokinase-type ...
Ajtai, Katalin +3 more
core +1 more source
Activity gradients in two- and three-dimensional active nematics [PDF]
arXiv, 2022 We numerically investigate how spatial variations of extensile or contractile active stress affect bulk active nematic systems in two and three dimensions. In the absence of defects, activity gradients drive flows which re-orient the nematic director field and thus act as an effective anchoring force.
arxiv
Cardio-OncologyBackground Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu +10 more
doaj +1 more source
Migrating Keratinocytes Express Urokinase-Type Plasminogen Activator
Journal of Investigative Dermatology, 1987 When confluent keratinocyte cultures were wounded by cutting with a blade, the cells rapidly retracted from the wounded site, leaving an area denuded of cells. Within 3-4 h of wounding, keratinocytes began to migrate from the edges and gradually reepithelialized the entire denuded area.
Shinji Morioka +3 more
openaire +3 more sources
Urokinase-Type Plasminogen Activator Inhibits Efferocytosis of Neutrophils [PDF]
American Journal of Respiratory and Critical Care Medicine, 2010 Phagocytosis of apoptotic cells, also called efferocytosis, plays an essential role in the resolution of inflammation. Urokinase-type plasminogen activator (uPA) is a multifunctional protein that has been implicated in inflammatory conditions, including pneumonia and severe infection, which are often accompanied by the development of acute lung injury.
Yanping Yang +6 more
openaire +3 more sources
Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis
Advanced Science, EarlyView.In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li +6 more
wiley +1 more source