Results 131 to 140 of about 78,313 (276)

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

Comparison of in Vivo Biochemical Effects of Human Urokinase Prepared from Urinary and Tissue Culture Sources [PDF]

, 1977
Victor J. Marder, Joseph F. Donahoe, William R. Bell, John J. Cranley, Hau C. Kwaan, Arthur A. Sasahara, Grant H. Barlow   +6 more
openalex   +1 more source

Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy

Small Structures, Volume 6, Issue 6, June 2025.
Low‐intensity focused ultrasound (LIFU)‐responsive nanobubbles (PAF@M) specifically target thrombus sites and penetrate thrombi under LIFU stimulation. Meanwhile, the liquid–gas phase transition of perfluoropentane and the release of nitric oxide synergistically enhance ultrasonic cavitation to destroy thrombus structure, providing a safe and effective
Wenli Zhang, Maoyuan Sun, Lian Xu, Sijin Chen, Xiyue Rong, Junrui Wang, Jia Liu, Bo Liu, Jie Xu, Ying Luo, Qianying Du, Yi Wang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo   +15 more
wiley   +1 more source

Profiles of local fibrinolytic activity before and after urokinase injection into the human empyema cavity. [PDF]

, 1970
Yong Hoon Kim, Jong Bong Kim, Jong Ho Moon, Dong Who Song, Hyeon Tae Kim, Dong Ho Yang, Sang Moo Lee, Soo Taek Yh, Choon‐Sik Park   +8 more
openalex   +1 more source

Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing SERPINE1 at Breast Cancer Metastatic Sites

Cancer Science, Volume 116, Issue 6, Page 1604-1615, June 2025.
Vascular permeability is increased by lung metastasis, which correlates with YAP activation in ECs. Activated ECs provide SERPINE1 to neighboring cancer cells to promote chemoresistance and stemness. ABSTRACT Chemotherapy resistance remains a major obstacle for eradicating metastatic cancer cells in distant organs. We identified that endothelial cells (
Tsunaki Hongu, Sarenqiqige, Shandan, Hirokazu Kusunoki, Akihiko Ishimura, Takeshi Suzuki, Thordur Oskarsson, Noriko Gotoh   +7 more
wiley   +1 more source

Surgical Treatment Could Improve Long‐Term Functional Outcomes in Intracerebral Hemorrhage Patients With NIHSS ≥ 10

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Surgical treatment can decrease disability (mRS 0–3) in supratentorial ICH patients with an NIHSS score ≥ 10. In the surgical treatment group, supratentorial ICH patients had a more favorable mRS distribution of functional outcomes compared to the medical treatment group.
Guangshuo Li, Kaijiang Kang, Yi Ju, Yang Du, Anxin Wang, Xiaoli Zhang, Yunyun Xiong, Xingquan Zhao, Wenjuan Wang   +8 more
wiley   +1 more source

The factor VII activating protease G511E (Marburg) variant and cardiovascular risk [PDF]

, 2004
A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a ...
Cooper, J.A., Humphries, S.E., Ireland, H., Miller, G.J., Webb, K.E.   +4 more
core  

Concentrations of plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in induced sputum of asthma patients after allergen challenge

Folia Histochemica et Cytobiologica, 2010
Urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) are involved in tiisue remodeling and repairprocesses associated with acute and chronic inflammation. The aim of the study was to evaluate the effect of allergen challengeon concentration of
Krzysztof Kowal,, Marcin Moniuszko, Sebastian Zukowski, Anna Bodzenta-Lukaszyk   +3 more
doaj  

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

Leveraging In Silico and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Incorporating inter‐individual differences in drug disposition and responses is essential for ensuring the safe and effective use of drugs in real‐world patients. Despite ongoing efforts, lower participation of children, older individuals, pregnant and breastfeeding women, postmenopausal women, and people with disease states and disabilities ...
Kyunghee Yang, Daniel Gonzalez, Jeffrey L. Woodhead, Pallavi Bhargava, Murali Ramanathan   +4 more
wiley   +1 more source