Results 141 to 150 of about 32,805 (191)
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Annals of the New York Academy of Sciences, 1988
Developpement d'un nouveau procede de modification de l'urokinase par la serumalbumine humaine. Avantages de cette urokinase modifiee: resistance a la chaleur, a la pepsine et a un inhibiteur placentaire de l ...
B Z, Shi, G D, Mao, Z P, Xiong
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Developpement d'un nouveau procede de modification de l'urokinase par la serumalbumine humaine. Avantages de cette urokinase modifiee: resistance a la chaleur, a la pepsine et a un inhibiteur placentaire de l ...
B Z, Shi, G D, Mao, Z P, Xiong
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The kringle stabilizes urokinase binding to the urokinase receptor
Blood, 2003AbstractThe structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (ΔK-scuPA) bound to soluble uPAR (suPAR) with the similar “on-rate” but ...
Khalil, Bdeir +7 more
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Magnetic urokinase: Targeting of urokinase to fibrin clot
Biochemical and Biophysical Research Communications, 1988A plasminogen activator of human origin, urokinase, was endowed with magnetic property. The magnetic urokinase was composed of magnetite, polyethylene glycol derivative and urokinase, and dispersed in saline. Its particle size of magnetite was approximately 30-60 nm.
Tatsuyuki Yoshimoto +5 more
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Studies on Metabolism of Urokinase and Mechanism of Thrombolysis by Urokinase
Thrombosis and Haemostasis, 1979SummaryPharmacokinetics of intravenously injected 125I-labeled urokinase (125I-UK) of a molecular weight of 33,000 daltons in normal rabbits and patients with various diseases were investigated. The plasma clearance of 125I-UK in rabbits was described by a biexponential curve within six hours with a half-life of 8 minutes, 2.3 hours, respectively.
T, Ueno, N, Kobayashi, T, Maekawa
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Urokinase and Single-Chain Urokinase-Type Plasminogen Activator (Pro-urokinase)
2001The discovery of urokinase (UK) is described in chap. 4. The UK in urine is not a waste product as shown by studies of the fate of intravenous injections of UK, which was found not to be excreted by the kidney (Fletcher et al. 1965). Instead, it is secreted by renal tubular cells (Sappino et al.
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