Results 251 to 260 of about 78,313 (276)
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The Immunoassay of Human Urokinase
Thrombosis and Haemostasis, 1969SummaryUrokinase with an activity of 45,200 CTA nnits/mg was used in 0.4 mg amounts with Freund’s adjuvant to immunize four individual rabbits by two injections spaced 4 weeks apart. All antisera were titrated for inhibition of urokinase activation of plasminogen, for double diffusion in Agarose, and for immunoelectrophoresis. Against constant portions
Anne P. Ball +4 more
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Urokinase/Urokinase Receptor-Mediated Signaling in Cancer
2007Experimental oncogenic transformation or in spontaneous human cancers, mitogenesis and expression of fibrinolytic components such as urokinase (uPA), its receptor (uPAR), and its major inhibitor plasminogen activator inhibtor-1 (PAI-1) or -2 (PAI-2) are activated by common signaling mechanisms.
Sreerama Shetty, Steven Idell
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Studies with a Preparation of Urokinase
Thrombosis and Haemostasis, 1967SummaryThe evidence presented in this paper shows that though less coagulative than urokinase (Leo), urokinase (Abbott), both in vitro and in vivo, has coagulant activity. Further, evidence has been presented that urokinase may accelerate platelet aggregation.
Patricia A. Wilson +3 more
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Fibrinolytic and fibrinogenolytic effects of acyl urokinase and urokinase combinations in vitro
Russian Journal of Bioorganic Chemistry, 2006The in vitro thrombolytic and side effects of double-strand urokinase-type plasminogen activator (tcu-PA), p-guanidinobenzoyl tcu-PA (GB-tcu-PA), and their combinations were compared. The reversible blocking of the active site stabilizes GB-tcu-PA in human plasma and results in longer thrombolysis and lesser side effects than those of tcu-PA.
L.I. Mukhametova +2 more
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The Urokinase Receptor Interactome
Current Pharmaceutical Design, 2011The urokinase receptor (uPAR) was originally identified as the membrane receptor of the serine protease urokinase (uPA), thereby implicated in the plasminogen activation cascade and regulation of pericellular proteolysis. Later on, vitronectin was showed to be another major ligand providing uPAR with a role in cell adhesion.
Gabriele Eden +4 more
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The role of urokinase and urokinase inhibitor in tumour cell metastasis
Fibrinolysis, 1992Abstract In this paper we summarize experiments in which murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for prep rourokinase. B16-F1 cells selected for their secretion of high amounts of the human urokinase gene product (3- to 4-fold higher plasminogen activator activity than control cells) formed ...
H. Yu, Jian-Yi Zhang, R.M. Schultz
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Urokinase and urokinase receptor expression in somatic cell hybrids
Fibrinolysis, 1994To study the mechanisms that control cell-bound urokinase (u-PA) activity we characterised the expression of u-PA and its cellular receptor (u-PAR) in somatic cell hybrids between mouse L fibroblasts that do not produce u-PA and human HT1080 fibrosarcoma cells that express high levels of u-PA and u-PAR. Although the hybrids possessed a number of copies
Mazzieri R. +8 more
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The preparation of human urokinase
The American Journal of Cardiology, 1960Abstract A highly potent preparation of urokinase has been separated from human urine and has been successfully heat-treated for ten hours at 60 °c. It is free of thromboplastic activity and is non-pyrogenic. This preparation was successfully used to prepare fibrinolysin from human, heat-treated profibrinolysin.
K.B. McCall, J. K. Inman, J. T. Sgouris
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1979
Fibrin deposition occurs in health and disease. The formation of fibrin results from the sequential activation of proteases according to a scheme now well known as the coagulation cascade. A variety of stimuli can initiate this cascade and the resultant fibrin may be involved in physiological (healing) or pathological (vascular obstruction) sequelae ...
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Fibrin deposition occurs in health and disease. The formation of fibrin results from the sequential activation of proteases according to a scheme now well known as the coagulation cascade. A variety of stimuli can initiate this cascade and the resultant fibrin may be involved in physiological (healing) or pathological (vascular obstruction) sequelae ...
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Biological chemistry Hoppe-Seyler, 1995
The urokinase-type plasminogen activator (uPA) is secreted as a single-chain inactive zymogen (pro-uPA). Upon its secretion, pro-uPA binds to its glycosylphosphatidylinositol-anchored specific cell receptor (uPAR). The activation of pro-uPA to the active two-chain uPA is accelerated with uPAR-bound pro-uPA and is achieved by plasmin and proteases of ...
CONESE, MASSIMO, F. Blasi
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The urokinase-type plasminogen activator (uPA) is secreted as a single-chain inactive zymogen (pro-uPA). Upon its secretion, pro-uPA binds to its glycosylphosphatidylinositol-anchored specific cell receptor (uPAR). The activation of pro-uPA to the active two-chain uPA is accelerated with uPAR-bound pro-uPA and is achieved by plasmin and proteases of ...
CONESE, MASSIMO, F. Blasi
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