Results 271 to 280 of about 99,653 (320)

Urokinase

New England Journal of Medicine, 1967
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Studies on Metabolism of Urokinase and Mechanism of Thrombolysis by Urokinase [PDF]

Thrombosis and Haemostasis, 1979
SummaryPharmacokinetics of intravenously injected 125I-labeled urokinase (125I-UK) of a molecular weight of 33,000 daltons in normal rabbits and patients with various diseases were investigated. The plasma clearance of 125I-UK in rabbits was described by a biexponential curve within six hours with a half-life of 8 minutes, 2.3 hours, respectively.
Tatsuo Ueno, Norio Kobayashi, Tadashi Maekawa   +2 more
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Studies on urokinase. the measurement of urokinase

Clinica Chimica Acta, 1966
Abstract A simple method for the determination of urokinase is described. This was performed by measuring the lysis times of standard fibrin clots containing dilutions of a urine or a urokinase standard preparation. The factors that might influence the results of this assay were investigated.
K. Deggeller, J. Vreeken, J. Boomgaard, A. Bleyenberg   +3 more
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Modification of Urokinase

Annals of the New York Academy of Sciences, 1988
Developpement d'un nouveau procede de modification de l'urokinase par la serumalbumine humaine. Avantages de cette urokinase modifiee: resistance a la chaleur, a la pepsine et a un inhibiteur placentaire de l ...
Guodong Mao, Bingzhao Shi, Zhenping Xiong   +2 more
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Magnetic urokinase: Targeting of urokinase to fibrin clot

Biochemical and Biophysical Research Communications, 1988
A plasminogen activator of human origin, urokinase, was endowed with magnetic property. The magnetic urokinase was composed of magnetite, polyethylene glycol derivative and urokinase, and dispersed in saline. Its particle size of magnetite was approximately 30-60 nm.
Tatsuyuki Yoshimoto, Kimiko Ohwada, Katsunobu Takahashi, Ayako Matsushima, Yuji Saito, Yuji Inada   +5 more
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Urokinase-Conjugated Magnetite Nanoparticles as a Promising Drug Delivery System for Targeted Thrombolysis: Synthesis and Preclinical Evaluation.

ACS Applied Materials and Interfaces, 2018
Mortality and disabilities as outcomes of cardiovascular diseases are primarily related to blood clotting. Optimization of thrombolytic drugs is aimed at the prevention of side effects (in particular, bleeding) associated with a disbalance between ...
A. Prilepskii, A. Fakhardo, A. Drozdov, V. Vinogradov, I. P. Dudanov, A. Shtil, Petr Bel'tyukov, A. Shibeko, E. Koltsova, D. Nechipurenko, V. Vinogradov   +10 more
semanticscholar   +1 more source

6 The urokinase/urokinase-receptor system and cancer invasion

Baillière's Clinical Haematology, 1995
u-PA binds with high affinity to its specific GPI-anchored receptor on the cell surface. The binding has at least two important consequences: (1) it enhances the rate of plasminogen activation on the cell surface; and (2) it focuses the u-PA proteolytic activity at the leading front of migrating cells. Several recent findings suggest that surface-bound
CONESE, MASSIMO, F. Blasi
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The kringle stabilizes urokinase binding to the urokinase receptor

Blood, 2003
AbstractThe structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (ΔK-scuPA) bound to soluble uPAR (suPAR) with the similar “on-rate” but ...
Abd Al-Roof Higazi, Andrew P. Mazar, Khalil Bdeir, Alice Kuo, Douglas B. Cines, Bruce S. Sachais, Ann H. Rux, Yasmina Bdeir   +7 more
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Effects of Pro-Urokinase and Urokinase on the Fibrinolytic System in Man

Pathophysiology of Haemostasis and Thrombosis, 1987
The fibrinolytic and fibrinogenolytic properties of kidney cell pro-urokinase (PUK) were compared with those of natural urinary urokinase in human volunteers. Comparable degrees of fibrinolysis were obtained at a concentration of 500,000 U UK and a concentration of 500,000 IU natural urokinase.
Dieter Welzel, Gustav Trübestein, Wolf Helmut, Smilja Popov   +3 more
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Studies on the Biochemistry of Urokinase

Thrombosis and Haemostasis, 1977
SummaryDirect evidence for an active center histidine residue in urokinase (UK) was obtained with use of newly synthesized peptide chloroketones Ac-Gly-Lys-CH2C1 and Nle-Gly-Lys-CH2C1. Stoichiometric inactivation by DFP provided further evidence that UK is a serine protease.
Guenther Schoellmann, Mercedes E. Soberano, Eng Bee Ong, Alan J. Johnson   +3 more
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