Results 291 to 300 of about 99,653 (320)

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

Journal of Cellular Physiology, 2019
Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid cancer development. Forthcoming evidence suggest that the stratified program transforms polarized, immotile epithelial cells to migratory mesenchymal cells ...
Vishal Das, Sourya Bhattacharya, C. Chikkaputtaiah, Saugata Hazra, Mintu Pal   +4 more
semanticscholar   +1 more source

The role of urokinase and urokinase inhibitor in tumour cell metastasis

Fibrinolysis, 1992
Abstract In this paper we summarize experiments in which murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for prep rourokinase. B16-F1 cells selected for their secretion of high amounts of the human urokinase gene product (3- to 4-fold higher plasminogen activator activity than control cells) formed ...
H. Yu, Jian-Yi Zhang, R.M. Schultz
openaire   +2 more sources

The preparation of human urokinase

The American Journal of Cardiology, 1960
Abstract A highly potent preparation of urokinase has been separated from human urine and has been successfully heat-treated for ten hours at 60 °c. It is free of thromboplastic activity and is non-pyrogenic. This preparation was successfully used to prepare fibrinolysin from human, heat-treated profibrinolysin.
K.B. McCall, J. K. Inman, J. T. Sgouris
openaire   +3 more sources

Urokinase and urokinase receptor expression in somatic cell hybrids

Fibrinolysis, 1994
To study the mechanisms that control cell-bound urokinase (u-PA) activity we characterised the expression of u-PA and its cellular receptor (u-PAR) in somatic cell hybrids between mouse L fibroblasts that do not produce u-PA and human HT1080 fibrosarcoma cells that express high levels of u-PA and u-PAR. Although the hybrids possessed a number of copies
Mazzieri R., Høyer Hansen G., Rønne E., Løber D., Vagnarelli P., De Carli L., Danø K., Mignatti P., RAIMONDI, ELENA MARIA   +8 more
openaire   +3 more sources

Urokinase as a Cell Product

1979
Fibrin deposition occurs in health and disease. The formation of fibrin results from the sequential activation of proteases according to a scheme now well known as the coagulation cascade. A variety of stimuli can initiate this cascade and the resultant fibrin may be involved in physiological (healing) or pathological (vascular obstruction) sequelae ...
openaire   +3 more sources

Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation.

Biological chemistry Hoppe-Seyler, 1995
The urokinase-type plasminogen activator (uPA) is secreted as a single-chain inactive zymogen (pro-uPA). Upon its secretion, pro-uPA binds to its glycosylphosphatidylinositol-anchored specific cell receptor (uPAR). The activation of pro-uPA to the active two-chain uPA is accelerated with uPAR-bound pro-uPA and is achieved by plasmin and proteases of ...
CONESE, MASSIMO, F. Blasi
openaire   +1 more source

Die Urokinase des Meerschweinchens

Experientia, 1964
In contrast to the urinary fibrinolysokinase (=urokinase) of other species, the urokinase in guineapigs reveals a most peculiar behaviour. A significant and well reproducible activation of fibrinolysin is obtainable only when guinea-pig fibrinolysin is used. Fibrinolysin of other species is only slightly activated.
openaire   +4 more sources

Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis.

Acta Biomaterialia, 2018
Nengpan Zhang, Chunlin Li, Dayong Zhou, Chen Ding, Yaqing Jin, Qingmei Tian, Xiangzhou Meng, Kefeng Pu, Yimin Zhu   +8 more
semanticscholar   +1 more source

UROKINASE IN OPHTHALMOLOGY

The Lancet, 1963
Dermot Pierse, Hylton Legrice
openaire   +3 more sources

UROKINASE IN PULMONARY EMBOLISM

The Lancet, 1973
ArthurA. Sasahara, TobyL. Simon, JamesM. Stengle   +2 more
openaire   +6 more sources