Results 41 to 50 of about 99,653 (320)

Estimating the Roles of Protonation and Electronic Polarization in Absolute Binding Affinity Simulations [PDF]

arXiv, 2021
Accurate prediction of binding free energies is critical to streamlining the drug development and protein design process. With the advent of GPU acceleration, absolute alchemical methods, which simulate the removal of ligand electrostatics and van der Waals interactions with the protein, have become routinely accessible and provide a physically ...
arxiv  

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar, Antonio Moschetta, Benedict Yan, Celestial T. Yap, Ee Hong Tan, Hwee Kee Tay, Jingli Zhuo, Lalchhandami Tochhawng, Manikandan Jayapal, Manuel Salto-Tellez, Shing Chuan Hooi, Shiuan Koh, Sutherland K. Maciver, Yaw Chong Goh, Yaw Chyn Lim   +14 more
core   +6 more sources

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors

Scientific Reports, 2017
The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface.
C. D. Mauro, A. Pesapane, L. Formisano, R. Rosa, V. D’Amato, P. Ciciola, A. Servetto, R. Marciano, Roberta C. Orsini, F. Monteleone, N. Zambrano, G. Fontanini, A. Servadio, G. Pignataro, L. Grumetto, A. Lavecchia, D. Bruzzese, A. Iaccarino, G. Troncone, B. M. Veneziani, N. Montuori, S. Placido, R. Bianco   +22 more
semanticscholar   +1 more source

Ultrasound-Guided Urokinase in the Remedy of Spontaneous Vaginal Hematoma After Vaginal Delivery: A Case Report

International Journal of Women's Health, 2023
Jin Shang,1 Juan Li,2 Qing Bai,2 Yongmei Wang,2 Hongjian Chen,1 Shunxu Li2 1Department of Ultrasound, The Third People’s Hospital of Yunnan, Kunming, People’s Republic of China; 2Department of Obstetrics, The Third People’s Hospital of Yunnan, Kunming ...
Shang J, Li J, Bai Q, Wang Y, Chen H, Li S   +5 more
doaj  

Urokinase vs Tissue-Type Plasminogen Activator for Thrombolytic Evacuation of Spontaneous Intracerebral Hemorrhage in Basal Ganglia

Frontiers in Neurology, 2017
Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke, which leads to a high rate of mortality and poor neurological outcomes worldwide.
Yuqian Li, Ruixin Yang, Zhihong Li, Bo Tian, Xingye Zhang, Jiancai Wang, Longlong Zheng, Boliang Wang, Lihong Li   +8 more
doaj   +1 more source

Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient

Open Medicine, 2023
Catheter-related bloodstream infection (CRBSI) is a significant complication among patients on haemodialysis (HD) who are dependent on a central venous catheter (CVC) for an extended period. Catheter removal as first-line treatment can induce accelerated
Xia Cong, Fan Junfen, Xu Chao, Hu Shouci, Ma Hongzhen, He Lingzhi, Ye Liqing   +6 more
doaj   +1 more source

Dissolution Effect of Alteplase on Arterial Blood Clot Model of Hypertensive Intracerebral Hemorrhage Patients in vitro

Frontiers in Neurology, 2022
ObjectiveTo explore the dissolution effect of alteplase (rt-PA) on arterial blood clots of patients with hypertensive cerebral hemorrhage in vitro and analyze the optimal concentration and action time of rt-PA for intracranial hematomas.MethodsThe ...
Xiaoming Jiang, Yongyu Lu, Xiaogang Hu, Xiaochun She   +3 more
doaj   +1 more source

Intrapleural injection of urokinase in the treatment of acute Haemophilus influenza empyema in children: A case report and literature review

Frontiers in Pediatrics, 2022
ObjectiveThe purpose of this study is to analyze the clinical data of a child with acute empyema caused by Haemophilus influenzae, and to investigate the diagnosis and treatment of this disease through literature review to improve the clinical ...
Lin Yang, YaFei Zhu, GuangSheng Wu
doaj   +1 more source

Minimally Invasive Technique for Spontaneous Intraparenchymal Hemorrhage

Indian Journal of Neurosurgery
Objective The aim of this study was to introduce a cost-effective and less invasive method for the evacuation of intraparenchymal hemorrhage (IPH).
Himanshu Raval, Kalpesh Shah, Mona Bhatt
doaj   +1 more source

Thrombectomy combined with indwelling-catheter thrombolysis is more effective than pure thrombectomy for the treatment of lower extremity deep venous thrombosis

Open Medicine, 2017
This study was a retrospective analysis of the efficacy of thrombectomy plus local catheter-directed thrombolysis (CDT) for the treatment of lower extremity deep venous thrombosis (LDVT).
Wang Wenli, Wu Yanfang, Fang Tao, Xu Dunyuan   +3 more
doaj   +1 more source