Results 111 to 120 of about 1,378,916 (231)

Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

Respiratory Research, 2018
Background The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality.
Nina S. Godtfredsen, Ditte V. Jørgensen, Kristoffer Marsaa, Charlotte S. Ulrik, Ove Andersen, Jesper Eugen-Olsen, Line J. H. Rasmussen   +6 more
doaj   +1 more source

Redrawing Urokinase Receptor (uPAR) Signaling with Cancer Driver Genes for Exploring Possible Anti-Cancer Targets and Drugs. [PDF]

Pharmaceuticals (Basel), 2023
Chang YC, Wu CZ, Cheng CW, Chen JS, Chang LC.   +4 more
europepmc   +1 more source

A Single Smart Nanomaterial for Near‐Infrared‐Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging

Small Science, Volume 6, Issue 11, November 2026.
A smart nanomaterial integrating Ag single atoms and nanoparticles on NiFe‐layered double hydroxides enables NIR‐switchable hemostasis and thrombolysis via photoelectric and photothermal effects. This platform allows real‐time photoacoustic imaging of active bleeding and exhibits rapid in vivo clearance, offering a dynamic theranostic strategy for ...
Yi Ye, Zhilu Sun, Daofu Wu, Jun’an Lai, Mingyue Yang, Zhiqiong Luo, Sha Cheng, Suwen Yang, Hong Zeng, Yinghui Li, Faguang Kuang, Baofei Sun, Wenxia Zhang, Xiaosheng Tang, Heng Luo, Guofeng Wu   +15 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Urokinase Plasminogen Activator

, 2016
The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion ...
Ali Salajegheh, Salajegheh, Ali
core   +1 more source

Urokinase Receptor uPAR Downregulation in Neuroblastoma Leads to Dormancy, Chemoresistance and Metastasis. [PDF]

Cancers (Basel), 2022
Shmakova AA, Klimovich PS, Rysenkova KD, Popov VS, Gorbunova AS, Karpukhina AA, Karagyaur MN, Rubina KA, Tkachuk VA, Semina EV.   +9 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Preclinical evaluation of the urokinase receptor-derived peptide UPARANT as an anti-inflammatory drug

, 2017
Inflammation plays a key role in the pathogenesis of several chronic diseases. The urokinase plasminogen activator receptor (uPAR) exerts a plethora of functions in both physiological and pathological processes, including ...
LISTA, LILIANA, Mario De Rosa, Angela Ianaro, Vito de Novellis, de Novellis, Vito, IANARO, ANGELA, Elisabetta Panza, Vincenzo Pavone, Carmela Belardo, Boccella, Serena, DE ROSA, MARIO, Liliana Lista, PANZA, ELISABETTA, Serena Boccella, Belardo, Carmela, PAVONE, VINCENZO   +15 more
core   +1 more source

The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities. [PDF]

Cancers (Basel), 2021
Metrangolo V, Ploug M, Engelholm LH.
europepmc   +1 more source

Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou, Xiyuan Fang, Xin Zhou, Zhao Zhang, Yu Hu, Zhipeng Cheng   +5 more
wiley   +1 more source