Results 81 to 90 of about 27,231 (235)
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
The urokinase receptor as an entertainer of signal transduction
Frontiers in Bioscience, 2009 The serine-protease urokinase (uPA) and its specific membrane receptor uPAR controls matrix degradation through the conversion of plasminogen into plasmin and play a crucial role in a number of biological processes including local fibrinolysis, inflammation, angiogenesis, matrix remodelling during wound healing, tumor invasion and metastasis.
Silvia, D'Alessio, Francesco, Blasi
openaire +2 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
Participation of the urokinase receptor in neutrophil efferocytosis
Blood, 2009 AbstractThe urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils. Macrophages from uPAR−/− mice demonstrated enhanced ability to engulf viable wild-type (WT) neutrophils in vitro and in vivo in the ...
Young-Jun, Park +4 more
openaire +3 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source
Urokinase–urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication [PDF]
Proceedings of the National Academy of Sciences, 2002 Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1. Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF ...
Alfano M +4 more
openaire +3 more sources
Urokinase Plasminogen Activator
, 2016 The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion ...
Ali Salajegheh, Salajegheh, Ali
core +1 more source
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy
Epilepsia, EarlyView.Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara +7 more
wiley +1 more source
Urokinase receptor mediates mechanical force transfer across the cell surface
, 1995 The tripartite complex formed by the urokinase receptor, urokinase, and its inhibitor is an enzymatic system that controls plasmin formation involved in degradation of extracellular matrix proteins.
N. Wang +4 more
core +1 more source
PAI‐1 inhibits urokinase‐induced chemotaxis by internalizing the urokinase receptor
FEBS Letters, 2001 PAI‐1 (plasminogen activator inhibitor‐1) binds the urokinase‐type plasminogen activator (uPA) and causes its degradation via its receptor uPAR and low‐density lipoprotein receptor‐related protein (LRP). While both uPA and PAI‐1 are chemoattractants, we find that a preformed uPA–PAI‐1 complex has no chemotactic activity and that PAI‐1 inhibits uPA ...
B. DEGRYSE +4 more
openaire +3 more sources