Microbial Metabolite, Macro Impact: Urolithin A in the Nexus of Insulin Resistance and Colorectal Tumorigenesis. [PDF]
NutrientsJoseph V +3 more
europepmc +1 more source
Oenological tannins mitigate rotenone-induced mitochondrial impairments and oxidative stress, with concomitant detection of urolithin A in the brain. [PDF]
Biochem Biophys RepWojciechowska O +7 more
europepmc +1 more source
Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species. [PDF]
Nat CommunPidgeon R +6 more
europepmc +1 more source
From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects. [PDF]
Nutr RevDomínguez-López I +5 more
europepmc +1 more source
Antiatherogenic effects of ellagic acid and urolithins in vitro
Archives of Biochemistry and Biophysics, 2016 Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors. Ellagitannins are a class of phenolic compounds that may play a role in cardiovascular health. This work aimed to study the potential atheroprotective effects of urolithins, ellagitannin-derived gut
Daniele Del Rio +2 more
exaly +4 more sources
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The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action
Mini-Reviews in Medicinal Chemistry, 2023Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu
exaly +3 more sources
Gastrointestinal stability of urolithins: an in vitro approach
European Journal of Nutrition, 2015Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
MENA PARRENO, Pedro Miguel +4 more
openaire +5 more sources
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang +3 more
openaire +2 more sources
The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
Current Cancer Drug Targets, 2022Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...
openaire +2 more sources
Research progress of ellagitannin intestinal metabolite urolithins
China Journal of Chinese Materia Medica, 2016Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou +5 more
openaire +2 more sources