Results 111 to 120 of about 1,721 (201)

UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals

, 2016
Urolithins are microbial metabolites produced from ellagic acid after the intake of dietary ellagitannins by different animals. Urolithin metabolites have distinct UV spectra that enable their detection and differentiation by HPLC coupled with UV ...
Pilar Truchado (2099287), Juan C. Espín (1961374), Francisco A. Tomás-Barberán (2099284), Rocío González-Barrio (2099281), Hideyuki Ito (658182)   +4 more
core   +1 more source

Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds

Gut Microbes
The fruits and vegetables we consume as part of our diet are rich in bioactive metabolites that can prevent and ameliorate cardiometabolic diseases, cancers, and neurological conditions. Polyphenols are a major metabolite family that has been intensively
Sara Alqudah, Jan Claesen
doaj   +1 more source

Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Antioxidants
Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis ...
Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer   +3 more
doaj   +1 more source

Urolithins and Their Precursors Ellagic Acid and Ellagitannins: Natural Sources, Extraction and Methods for Their Determination

Separations
In the present review, we discuss the occurrence of ellagitannins (ETs) and ellagic acid (EA) and methods for their isolation from plant materials. We summarize analytical methods, including high-performance liquid chromatography–ultraviolet (HPLC–UV ...
Christiana Mantzourani, Eleni Kakouri, Konstantinos Palikaras, Petros A. Tarantilis, Maroula G. Kokotou   +4 more
doaj   +1 more source

Strawberry Processing Does Not Affect the Production and Urinary Excretion of Urolithins, Ellagic Acid Metabolites, in Humans

, 2011
The study of fruit and vegetable processing and its effects on the levels of health-promoting constituents and their bioavailability and metabolism is very relevant to understanding the role of these constituents in human health.
Larrosa, Mar, Francisco A. Tomás-Barberán, Vidal-Guevara, María Luisa, María Luisa Vidal-Guevara, María Teresa García-Conesa, García-Conesa, María Teresa, Pilar Truchado, Cerdá, Begoña, Truchado, Pilar, Tomás Barberán, Francisco, Begoña Cerdá, Juan Carlos Espín, Espín de Gea, Juan Carlos, Mar Larrosa   +13 more
core   +1 more source

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

, 2015
Diabetic cardiomyopathy (DCM) develops independently of common cardiovascular comorbidities and is initiated by the metabolic derangements accompanying diabetes mellitus, including hyperglycaemia, which may cause a mild inflammatory state able to ...
SALA, Roberto, BRIGHENTI, Furio, SAVI, Monia, STILLI, Donatella, MENA PARRENO, Pedro Miguel, DEL RIO, Daniele, MIRAGOLI, MICHELE, Crozier, Alan   +7 more
core   +1 more source

Therapeutic Potential of Ellagic Acid in Liver Diseases

Molecules
Ellagic acid (EA) is a natural polyphenol found in various fruits, nuts, and mushrooms. It exhibits a variety of biological activities, including potent antioxidant, anti-inflammatory, anti-obesity, and neuroprotective properties.
Karolina Wojtunik-Kulesza, Przemysław Niziński, Anna Krajewska, Tomasz Oniszczuk, Maciej Combrzyński, Anna Oniszczuk   +5 more
doaj   +1 more source

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Nature Communications, 2019
Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a ...
Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, Becca V. Baby, Bindu Hegde, Niranjan G. Kotla, Ankita A. Hiwale, Taslimarif Saiyed, Paresh Patel, Matam Vijay-Kumar, Morgan G. I. Langille, Gavin M. Douglas, Xi Cheng, Eric C. Rouchka, Sabine J. Waigel, Gerald W. Dryden, Houda Alatassi, Huang-Ge Zhang, Bodduluri Haribabu, Praveen K. Vemula, Venkatakrishna R. Jala   +20 more
doaj   +1 more source

Urolithins Are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in Free-Living Subjects with Diagnosed Metabolic Syndrome

, 2016
Walnuts (Juglans regia L.), hazelnuts (Corylus avellana L.), and almonds (Prunus dulcis Mill.) are rich sources of ellagitannins and proanthocyanidins. Gut microbiota plays a crucial role in modulating the bioavailability of these high molecular weight ...
Montserrat Rabassa (2045503), Patricia López-Uriarte (2045512), Olga Jáuregui (1645711), Francisco Tomás-Barberán (1961371), Mònica Bulló (2045515), Mireia Urpi-Sarda (1696219), Rocío Garcı́a-Villalba (2045509), Juan Carlos Espı́n (2045506), Sara Tulipani (342515), Jordi Salas-Salvadó (1696228), Cristina Andrés-Lacueva (1967038)   +10 more
core   +1 more source

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

Walnuts have been gathering attention for their health-promoting properties. They are rich in polyphenols, mainly ellagitannins (ETs) that after consumption are hydrolyzed to release ellagic acid (EA).
Ciudad i Gómez, Carlos Julián, Izquierdo Pulido, María Luz, Sánchez-González, Claudia, Noé Mata, Verónica   +3 more
core   +1 more source