Results 1 to 10 of about 3,771 (207)
Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis [PDF]
BiologyUrolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang +3 more
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Cells, 2022 In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar +2 more
exaly +4 more sources
Foods, 2022 Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people. Strains capable of producing urolithin A from ellagic acid have the hope of becoming the next-generation probiotics.
Qitong Liu +8 more
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Metagenomic insights into urolithin formation from rambutan rind extract by rat faecal-derived microbiome [PDF]
Applied Microbiology and BiotechnologyEllagitannins and ellagic acid are microbially converted into urolithins, metabolites associated with antioxidant, anti-inflammatory, and mitochondrial-related activities.
Wai-Kit Tow +6 more
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Molecules, 2022 Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus.
Mengjie Xiao +5 more
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The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
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Potential impact of urolithin A on pathways relevant to sleep health: a mini review [PDF]
Frontiers in NutritionSleep is vital to human health, and poor sleep health has been associated with numerous chronic conditions, including cardiovascular disease, obesity, depression, and type 2 diabetes. Recently, an emerging area of research has focused on the relationship
Ana Clara da C. Pinaffi-Langley +4 more
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A Systematic Study of the Hepatic–Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS [PDF]
MoleculesPunicalagin, the major polyphenol in pomegranate peel, shows broad bioactivity but suffers from poor oral bioavailability. Whether hepatic or intestinal first-pass processes dominate this limitation remains unresolved. We developed a quantitative UPLC-MS/
Zixin Chen +3 more
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Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases
Toxins, 2023 Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication
Mark Makarov, Eduard Korkotian
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Biochemistry and Biophysics Reports, 2021 Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria.
Hidehiko Kikuchi +3 more
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