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RETRACTED: Kshirsagar et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease. <i>Cells</i> 2022, <i>11</i>, 2660. [PDF]

Cells
The journal retracts the article titled “A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease” [...]
Kshirsagar S, Alvir RV, Pradeepkiran JA, Hindle A, Vijayan M, Ramasubramaniam B, Kumar S, Reddy AP, Reddy PH.   +8 more
europepmc   +3 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf-1/ERK1/2/PINK1 Signaling Axis. [PDF]

Adv Sci (Weinh)
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Zhang L, Li J, Zhang H, Qin Q, Huang Y, Tian X, Sun C, Li B, Wang Z, Zhang X.   +9 more
europepmc   +2 more sources

<i>Fucus</i><i>vesiculosus</i> Polysaccharide-Based Solid Dispersions Enhance Aqueous Dispersion and Gut Microbial Biotransformation of Ellagic Acid. [PDF]

Foods
Ellagic acid (EA) is a food-derived polyphenol with multiple biological activities, but its poor water solubility and aggregation in aqueous systems limit its accessibility to gut microorganisms.
Jia RB, Ou D, Liang F, Li ZR, Wang J, Zhou C, Hong P.   +6 more
europepmc   +2 more sources

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Henrotin Y, Florin A, Sanchez C, Centonze P, Coelho TP, Bekisz S, Dubuc JE, Galand O, Lambert C.   +8 more
europepmc   +2 more sources

A Novel Streptococcus thermophilus FUA329 Isolated from Human Breast Milk Capable of Producing Urolithin A from Ellagic Acid

Foods, 2022
Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people. Strains capable of producing urolithin A from ellagic acid have the hope of becoming the next-generation probiotics.
Qitong Liu, Shu Liu, Qinwen Ye, Xiaoyue Hou, Guang Yang, Jing Lu, Yang Hai, Juan Shen, Yaowei Fang   +8 more
doaj   +2 more sources

Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Biology
Urolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang, Ren Zhou, Yong Ruan, Shuhao Fan   +3 more
doaj   +2 more sources

RETRACTED: A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease

Cells, 2022
In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar, Rainier Vladlen Alvir, Jangampalli Adi Pradeepkiran, Ashly Hindle, Murali Vijayan, Bhagavathi Ramasubramaniam, Subodh Kumar, Arubala P. Reddy, P. Hemachandra Reddy   +8 more
doaj   +2 more sources

Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase

Molecules, 2022
Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus.
Mengjie Xiao, Fei Cao, Tao Huang, Yun-Sang Tang, Xin Zhao, Pang-Chui Shaw   +5 more
doaj   +2 more sources

Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer [PDF]

Frontiers in Pharmacology
BackgroundThe natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer.
Vladimir Rogovskii, Vladimir Rogovskii, Vladimir V. Murugin, Vladimir V. Murugin, Nikolay Vorobyev, Nikolay Vorobyev, Sergey Popov, Nikolay Sturov, Alexey Krasheninnikov, Alexander Morozov, Marina Prokhorova   +10 more
doaj   +2 more sources

Metagenomic insights into urolithin formation from rambutan rind extract by rat faecal-derived microbiome. [PDF]

Appl Microbiol Biotechnol
Ellagitannins and ellagic acid are microbially converted into urolithins, metabolites associated with antioxidant, anti-inflammatory, and mitochondrial-related activities.
Tow WK, Teh CSJ, Ooi CW, Lee RFS, Krishnasamy M, Palanisamy UD, Sundralingam U.   +6 more
europepmc   +2 more sources