Functional Food-Derived Urolithins: Molecular Mechanisms, Health Effects, and Interactomics with Proteins and Extracellular Vesicles [PDF]
MoleculesOver the past decade, research on urolithins has expanded significantly due to their role as mediators between polyphenol-rich diets and human health. Understanding the relationships between ellagitannin intake, gut microbiota composition, and urolithin ...
Nevena Zelenović +2 more
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The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
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Urolithins’ interaction with hepatocyte growth factor receptor: a mechanistic basis for anticancer activity in gastric adenocarcinoma cells [PDF]
Discover OncologyGastric adenocarcinoma (GAC) ranks among the most common cancers worldwide. Hepatocyte growth factor receptor, also known as MET, plays crucial roles in GAC progression.
Fatemehsadat Hosseini +4 more
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Cells, 2022 Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid).
Agnieszka Daca +2 more
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Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals [PDF]
Frontiers in NutritionThe intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition.
Lin Luo, Lin Luo
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Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives [PDF]
MoleculesThe present review offers a comprehensive synthesis of the structural diversity, natural occurrence, and therapeutic promise of key ellagitannins (punicalagin, sanguiin H-6, corilagin, geraniin, oenothein B, chebulagic, and chebulinic acids) within the ...
Rositsa Mihaylova +3 more
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From rumen to milk: Dietary polyphenols in dairy cows—A critical review [PDF]
Veterinary and Animal SciencePolyphenols represent a large and structurally diverse family of plant secondary metabolites with bioactive properties. In ruminants, these compounds can influence rumen fermentation, microbial ecology, and nutrient metabolism, offering potential ...
Lucrezia Forte +9 more
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A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin [PDF]
MoleculesSecondary polyphenol metabolites, urolithins (UROs), have anti-oxidative, anti-inflammatory, and antidiabetic properties. Therefore, their biological activity relies on blood transport via human serum albumin (HSA) and tissue distribution.
Nevena Zelenović +5 more
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In Vitro Anti-Inflammatory and Anticancer Potential of Pecan Nut (Carya illinoinensis) Kernel Extracts: Modulation of Cell Signaling Pathways—A Scoping Review [PDF]
MoleculesThis scoping review synthesized evidence from 2015 to 2025 on the anti-inflammatory and anticancer potential of pecan (Carya illinoinensis) kernel extracts, focusing on bioactive composition and cell signaling pathway modulation.
Ifeoma Roseline Ezeanolue +5 more
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Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies [PDF]
AntioxidantsPolyphenols, plant-derived secondary metabolites, play crucial roles in plant stress responses, growth regulation, and environmental interactions. In humans, polyphenols are associated with various health benefits, particularly in cardiometabolic health.
Ana Clara da C. Pinaffi-Langley +3 more
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