Urolithins in clinical translation: from gut microbial metabolites to precision interventions [PDF]
Frontiers in NutritionUrolithins are gut microbiota-derived metabolites generated from ellagitannins and ellagic acid, and have emerged as promising mediators at the diet–microbiota–host interface.
Lingmin Hu, Yingchun Ling, Weifeng Jin
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Functional Food-Derived Urolithins: Molecular Mechanisms, Health Effects, and Interactomics with Proteins and Extracellular Vesicles [PDF]
MoleculesOver the past decade, research on urolithins has expanded significantly due to their role as mediators between polyphenol-rich diets and human health. Understanding the relationships between ellagitannin intake, gut microbiota composition, and urolithin ...
Nevena Zelenović +2 more
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The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
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Cells, 2022 Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid).
Leszek Kalinowski +2 more
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Urolithin A has antiplatelet effects in contrast to its glucuronide, urolithin B, and isourolithin A [PDF]
Frontiers in Cardiovascular MedicineIntroductionConsumption of dietary ellagitannins has been suggested to have protective effects against cardiovascular disease, likely due to the colonic formation of urolithins and their subsequent systemic absorption.
Alina Soloviova +6 more
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Urolithins’ interaction with hepatocyte growth factor receptor: a mechanistic basis for anticancer activity in gastric adenocarcinoma cells [PDF]
Discover OncologyGastric adenocarcinoma (GAC) ranks among the most common cancers worldwide. Hepatocyte growth factor receptor, also known as MET, plays crucial roles in GAC progression.
Fatemehsadat Hosseini +4 more
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Fucus vesiculosus Polysaccharide-Based Solid Dispersions Enhance Aqueous Dispersion and Gut Microbial Biotransformation of Ellagic Acid [PDF]
FoodsEllagic acid (EA) is a food-derived polyphenol with multiple biological activities, but its poor water solubility and aggregation in aqueous systems limit its accessibility to gut microorganisms.
Rui-Bo Jia +6 more
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Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives [PDF]
MoleculesThe present review offers a comprehensive synthesis of the structural diversity, natural occurrence, and therapeutic promise of key ellagitannins (punicalagin, sanguiin H-6, corilagin, geraniin, oenothein B, chebulagic, and chebulinic acids) within the ...
Rositsa Mihaylova +3 more
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How Polyphenol Metabolites Spatiotemporally Reprogram Transcription Factors and Human Proteostasis: A Metabolite-Centric Framework [PDF]
Current Issues in Molecular BiologyPolyphenols act in humans through authentic metabolites, including regio-isomeric glucuronides/sulphates, O-methylated forms, and microbiota products (urolithins, γ-valerolactones, equol), that reach targets by spatiotemporally gated exposure.
José Manuel Pérez de la Lastra +4 more
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From rumen to milk: Dietary polyphenols in dairy cows—A critical review [PDF]
Veterinary and Animal SciencePolyphenols represent a large and structurally diverse family of plant secondary metabolites with bioactive properties. In ruminants, these compounds can influence rumen fermentation, microbial ecology, and nutrient metabolism, offering potential ...
Lucrezia Forte +9 more
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