Results 41 to 50 of about 1,983 (203)

Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review

Molecules, 2020
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA).
Dmitry D. Evtyugin, Sandra Magina, Dmitry V. Evtuguin   +2 more
doaj   +1 more source

Urolithins: Promising nutritional interventions for mild cognitive impairment

Journal of Functional Foods
Urolithins, a class of metabolites produced by the gut microbiota from dietary ellagic acid and ellagitannins, are abundant in various medicinal plants and foods, such as the formulation triphala, pomegranates, walnuts, and strawberries.
Wenjun Wang, Cai Rangji, Nanjia Cairang, Yi Ding, Yi Zhang, Renqing Duojie, Zhengxiang Zhang   +6 more
doaj   +1 more source

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

Frontiers in Microbiology, 2017
Urolithins are intestinal microbial metabolites produced from ellagitannin- and ellagic acid-containing foods such as walnuts, strawberries, and pomegranates.
María V. Selma, David Beltrán, María C. Luna, María Romo-Vaquero, Rocío García-Villalba, Alex Mira, Juan C. Espín, Francisco A. Tomás-Barberán   +7 more
doaj   +1 more source

Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment

Frontiers in Neuroscience, 2022
Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases.
Eduardo Duarte-Silva, Eduardo Duarte-Silva, Eduardo Duarte-Silva, Eduardo Duarte-Silva, Sven G. Meuth, Christina Alves Peixoto, Christina Alves Peixoto   +6 more
doaj   +1 more source

Enhancing the Efficacy of Radiotherapy in Gastric Adenocarcinoma Cells by Gut Microbiota Metabolites: Implications for Urolithin Combination Therapy

Natural Product Communications
Background Gastric adenocarcinoma (GA) ranks as the fourth leading cause of cancer-related mortality. The clinical effectiveness of radiotherapy in GA patients is often limited by the development of radiation resistance. Urolithins, which are metabolites
Abdolreza Ahmadi, Fatemehsadat Hosseini, Hassan Ostadi, Hamid Gholamhosseinian, Milad Iranshahy, Fatemeh B. Rassouli   +5 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Mitophagy Activation by Urolithin A to Target Muscle Aging

Calcified Tissue International, 2023
AbstractThe age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are tissues with high metabolic requirements, and contain rich mitochondria supply to support ...
Julie Faitg, Davide D’Amico, Chris Rinsch, Anurag Singh   +3 more
openaire   +3 more sources

Antioxidant and Antiglycation Effects of Cistus × incanus Water Infusion, Its Phenolic Components, and Respective Metabolites

Molecules, 2022
Reactive oxygen and carbonyl species promote oxidative and carbonyl stress, and the development of diabetes, metabolic syndrome, cardiovascular diseases, and others. The traditional herb Cistus × incanus is known for its antioxidant properties; therefore,
Karolina Bernacka, Katarzyna Bednarska, Aneta Starzec, Sylwester Mazurek, Izabela Fecka   +4 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source