Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist
Metabolites, 2018 Urolithins (e.g., UroA and B) are gut microbiota-derived metabolites of the natural polyphenol ellagic acid. Urolithins are associated with various health benefits, including attenuation of inflammatory signaling, anti-cancer effects and repression of ...
Gulsum E. Muku +3 more
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Ellagitannins (Ellagic Acid, Urolithin A, Urolithin B) Inhibit the Catalytic Activity of Human Recombinant Metalloproteinase 9. [PDF]
Iran J Pharm ResBackground: Ellagitannins are well-recognized for their antioxidant, chemopreventive, anti-inflammatory, and neuroprotective efficacy. Due to their poor absorption and extensive catabolism, it is proposed that urolithins, as ellagic acid (EA) metabolites, are the real active molecules exerting these biological functions.
Houssein-Zadeh N, Sadeghi L, Dehghan G.
europepmc +3 more sources
Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
Antioxidants, 2023 Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder characterized by a complex pathophysiology and a range of symptoms. The prevalence increases with age, putting the ageing population at risk. Disease management includes the improvement of symptoms, the comfort of the patient’s life, and palliative care.
Olga Wojciechowska, Małgorzata Kujawska
openaire +3 more sources
Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far [PDF]
, 2013 The health benefits attributed to pomegranate have been associated with its high content in polyphenols, particularly ellagitannins. This is also the case for other ellagitannin-containing fruits and nuts including strawberry, raspberry, blackberry ...
Larrosa, Mar +3 more
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Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review
Molecules, 2020 Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA).
Dmitry D. Evtyugin +2 more
doaj +1 more source
Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro [PDF]
Animals, 2021 Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested. Urolithin A (UA) is a natural metabolite with pro-apoptotic and antioxidant effects, capable of preventing the accumulation of dysfunctional mitochondria in different aged cells ...
Élisa Fonseca +6 more
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Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
Pharmaceutical Biology, 2022 L'urolithine A (UroA) peut inhiber la croissance de nombreuses cellules cancéreuses humaines, mais il n'a pas été rapporté si l'UroA inhibe les cellules de carcinome nasopharyngé (NPC). Pour explorer l'effet inhibiteur de l'UroA sur le NPC et le mécanisme potentiel in vitro.
Yang� Yang +8 more
openaire +3 more sources
Urolithins: Promising nutritional interventions for mild cognitive impairment
Journal of Functional FoodsUrolithins, a class of metabolites produced by the gut microbiota from dietary ellagic acid and ellagitannins, are abundant in various medicinal plants and foods, such as the formulation triphala, pomegranates, walnuts, and strawberries.
Wenjun Wang +6 more
doaj +1 more source
Frontiers in Microbiology, 2017 Urolithins are intestinal microbial metabolites produced from ellagitannin- and ellagic acid-containing foods such as walnuts, strawberries, and pomegranates.
María V. Selma +7 more
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Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment
Frontiers in Neuroscience, 2022 Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases.
Eduardo Duarte-Silva +6 more
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