Results 51 to 60 of about 1,427 (175)

Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Urolithin A (UA) treatment enhances the Nrf2/HO‐1‐mediated antioxidant capacity against ischemic injury postischemic stroke, while also effectively suppressing neuroinflammatory responses. Both of these regulatory effects are likely associated with the NF‐κB signaling pathway, which in turn inhibits neuronal apoptosis and contributes to the improvement
Yanxin Shao, Lina Feng, Yanchun Li, Yichen Cai, Hui Yuan, Qin Tang, Mingfeng Yang, Weixia Yang, Hong Shi, Leilei Mao   +9 more
wiley   +1 more source

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Fuxiang He, Yingying Bian, Yaling Zhao, Mengjie Xia, Shu Liu, Jiajin Gui, Xiaoyue Hou, Yaowei Fang   +7 more
openaire   +2 more sources

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

The improvement effect of ellagic acid and urolithins on metabolic diseases: Pharmacology and mechanism

Food & Medicine Homology
Epidemiological studies have demonstrated that a range of metabolic diseases, particularly type 2 diabetes and obesity, have reached epidemic proportions.
Ying-Hao Wang, Wen-Yuan Peng, Chun-Feng Li, Yi-Long Wu, Jun Sheng, Cheng-Ting Zi, Xiao-Yun Wu   +6 more
doaj   +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon, Md. Mizanur Rahaman, Dhrubo Sarder, Md. Shadin, Shamima Akter Neela, Phurpa Wangchuk, Subir Sarker   +6 more
wiley   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A

Beni-Suef University Journal of Basic and Applied Sciences
Background Despite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug resistance, an increase in overall treatment costs, and unanticipated side effects from pharmaceuticals.
Shilpa S. Shetty, Sandeep Shetty, N. Suchetha Kumari   +2 more
doaj   +1 more source

Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health

Microbiology Research
Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as
Erick M. Raya-Morquecho, Pedro Aguilar-Zarate, Leonardo Sepúlveda, Mariela R. Michel, Anna Iliná, Cristóbal N. Aguilar, Juan A. Ascacio-Valdés   +6 more
doaj   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source