Results 71 to 80 of about 1,983 (203)

Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A

Beni-Suef University Journal of Basic and Applied Sciences
Background Despite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug resistance, an increase in overall treatment costs, and unanticipated side effects from pharmaceuticals.
Shilpa S. Shetty, Sandeep Shetty, N. Suchetha Kumari   +2 more
doaj   +1 more source

Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health

Microbiology Research
Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as
Erick M. Raya-Morquecho, Pedro Aguilar-Zarate, Leonardo Sepúlveda, Mariela R. Michel, Anna Iliná, Cristóbal N. Aguilar, Juan A. Ascacio-Valdés   +6 more
doaj   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Ellagic Acid Enhances RSL3‐Induced Ferroptosis by Inhibiting the Nrf2/HO‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Ellagic acid potentiates RSL3‐induced ferroptosis in PANC‐1 by suppressing the Nrf2/HO‐1 antioxidant defense axis via p38 MAPK activation and Keap1 upregulation. In PDAC cells, constitutive Nrf2/HO‐1 signaling establishes a robust antioxidant shield (GPX4, HO‐1) that limits lipid ROS accumulation and confers ferroptosis resistance.
Jianhua Bai, Yihe Dai, Chern Ein Oon, Pingping Hu, Jia Luo, Jiang Han, Liman Yang, Amirabas Bostani, Zhenhao Fei, Yun Jin   +9 more
wiley   +1 more source

Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals

Frontiers in Nutrition
The intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition.
Lin Luo, Lin Luo
doaj   +1 more source

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor‐Specific Evidence, and Translational Roadmaps

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu, Yawei Jiao, Jiao Xue, Xiaoli Lv, Songbing Qin   +4 more
wiley   +1 more source

Urolithins: A Prospective Alternative against Brain Aging

, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing ...
Ke Wang, Lei An, Qiu Lu, Yousheng Wang
core   +1 more source

A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin

Molecules
Secondary polyphenol metabolites, urolithins (UROs), have anti-oxidative, anti-inflammatory, and antidiabetic properties. Therefore, their biological activity relies on blood transport via human serum albumin (HSA) and tissue distribution.
Nevena Zelenović, Predrag Ristić, Natalija Polović, Tamara Todorović, Milica Kojadinović, Milica Popović   +5 more
doaj   +1 more source

Unlocking the Hepatoprotective Potential of Urolithin A in High‐Fat Diet‐Induced MASLD: Integrated Role of Oxidative Stress, Inflammation, FXR/PPAR‐α, and Fibrotic Pathway

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT “Metabolic dysfunction–associated steatotic liver disease” (MASLD) is marked by hepatic steatosis, oxidative stress, inflammation, and fibrosis. Urolithin A (Uro A), a metabolite of ellagitannins, exhibits anti‐inflammatory, antioxidant, and metabolic regulatory activities.
Hamad Alsaykhan, Amany Mohamed Shalaby, Walaa Arafa Keshk, Shahd Saad El‐dien Kamel, Sulaiman Mohammed Alnasser, Mohammed Alorini, Fatima A. Jaber, Mohamed Ali Alabiad, Amr Mohamed Younes, Hanim Magdy Abdelnour   +9 more
wiley   +1 more source

Data_Sheet_1_Identification of ellagic acid and urolithins as natural inhibitors of Aβ25–35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking.PDF

, 2022
Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins.
Shi-Ying Zhang (13186503), Ying-Xin Zhou (13186512), Wei-Zhong Huang (13186515), Xiu-Hong Piao (13186518), Yue-Wei Ge (2871029), Zhi-You Yang (1523218), Shu-Mei Wang (1670437), Ying-Shan Ren (13186506), Hui-Lin Li (4962388), Jie-Chun Zhou (13186509)   +9 more
core   +1 more source