Results 71 to 80 of about 1,721 (201)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Data_Sheet_1_Identification of ellagic acid and urolithins as natural inhibitors of Aβ25–35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking.PDF

, 2022
Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins.
Shi-Ying Zhang (13186503), Ying-Xin Zhou (13186512), Wei-Zhong Huang (13186515), Xiu-Hong Piao (13186518), Yue-Wei Ge (2871029), Zhi-You Yang (1523218), Shu-Mei Wang (1670437), Ying-Shan Ren (13186506), Hui-Lin Li (4962388), Jie-Chun Zhou (13186509)   +9 more
core   +1 more source

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

Experimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi, Josh Thorley, Ana Rodriguez‐Mateos, Zicheng Zhang, Lewis J James, Tom Clifford   +5 more
wiley   +1 more source

The improvement effect of ellagic acid and urolithins on metabolic diseases: Pharmacology and mechanism

Food & Medicine Homology
Epidemiological studies have demonstrated that a range of metabolic diseases, particularly type 2 diabetes and obesity, have reached epidemic proportions.
Ying-Hao Wang, Wen-Yuan Peng, Chun-Feng Li, Yi-Long Wu, Jun Sheng, Cheng-Ting Zi, Xiao-Yun Wu   +6 more
doaj   +1 more source

Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate Extract on the Gut Microbiome and Short-Chain Fatty Acids

Foods, 2023
Punica granatum L., commonly known as the pomegranate, is an abundant source of polyphenols, including hydrolyzable ellagitannins, ellagic acid, anthocyanins, and other bioactive phytochemicals shown to be effective in defending against oxidative stress,
Raja K. Sivamani, Mincy Chakkalakal, Adrianne Pan, Dawnica Nadora, Mildred Min, Ashley Dumont, Waqas A. Burney, Cindy J. Chambers   +7 more
doaj   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

Interactions of Different Urolithins With Bovine Serum Albumin [PDF]

, 2023
Backgound/Objectives: Urolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are transported through the systemic circulation to various ...
Zelenović, Nevena, Filipović, Lidija, Vesna Vucic, Lidija Filipovic, Aleksndra Arsic, Popović, Milica, Popović, Milica M., Kojadinović, Milica, Popovic, Lidija, Milos Milcic, Vučić, Vesna, Milica Popovic, Arsić, Aleksandra, Milica Kojadinovic, Zelenović, Nevena D., Nevena Zelenovic, Kojadinović, Milica I., Vučić, Vesna M., Milčić, Miloš, Milčić, Miloš K., Arsić, Aleksndra   +20 more
core   +1 more source

Therapeutic efficacy of gut microbiota-derived polyphenol metabolite Urolithin A

Beni-Suef University Journal of Basic and Applied Sciences
Background Despite rising public awareness and improvements in diagnostic and treatment methods, there are adverse effects brought on by drug resistance, an increase in overall treatment costs, and unanticipated side effects from pharmaceuticals.
Shilpa S. Shetty, Sandeep Shetty, N. Suchetha Kumari   +2 more
doaj   +1 more source

Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health

Microbiology Research
Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as
Erick M. Raya-Morquecho, Pedro Aguilar-Zarate, Leonardo Sepúlveda, Mariela R. Michel, Anna Iliná, Cristóbal N. Aguilar, Juan A. Ascacio-Valdés   +6 more
doaj   +1 more source