Results 61 to 70 of about 2,467 (216)

Urolithin A attenuates auditory cell senescence by activating mitophagy

Scientific Reports, 2022
AbstractAging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells.
Sung Il Cho, Eu-Ri Jo, Hansoo Song
openaire   +3 more sources

Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Oxidative stress is a state of excess of prooxidative species relative to the antioxidant defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this imbalance is damage of the major cellular macromolecules (carbohydrates, lipids, proteins, and DNA), which further leads to a gradual loss of tissue and organ function. It has been
Jasmina Djedjibegovic, Aleksandra Marjanovic, Emiliano Panieri, Luciano Saso   +3 more
openaire   +2 more sources

Exploring the role of LDH in cancer cells through the use of small-molecule inhibitors. [PDF]

, 2018
Metabolic reprogramming represents a potential therapeutic target in cancer. The studies of this thesis work lead to assume the enzyme lactate dehydrogenase (LDH) as key element coordinating neoplastic proliferation and invasive growth, suggesting for ...
Di Ianni, Lorenza <1987>
core   +1 more source

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Fuxiang He, Yingying Bian, Yaling Zhao, Mengjie Xia, Shu Liu, Jiajin Gui, Xiaoyue Hou, Yaowei Fang   +7 more
openaire   +2 more sources

Enhancing the Efficacy of Radiotherapy in Gastric Adenocarcinoma Cells by Gut Microbiota Metabolites: Implications for Urolithin Combination Therapy

Natural Product Communications
Background Gastric adenocarcinoma (GA) ranks as the fourth leading cause of cancer-related mortality. The clinical effectiveness of radiotherapy in GA patients is often limited by the development of radiation resistance. Urolithins, which are metabolites
Abdolreza Ahmadi, Fatemehsadat Hosseini, Hassan Ostadi, Hamid Gholamhosseinian, Milad Iranshahy, Fatemeh B. Rassouli   +5 more
doaj   +1 more source

Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β stimulated SK-N-SH cells [PDF]

, 2015
Purpose: Pomegranate fruit, Punica granatum L. (Punicaceae) and its constituents have been shown to inhibit inflammation. In this study we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β stimulated SK-N-SH cells.
A Oucharif, B Romier, B Romier-Crouzet, CH Chen, CJ Lee, D Bialonska, D Paris, DJ Selkoe, EM Sutinen, F Lei, G Marwarha, GM Pasinetti, GP Lim, K Blennow, K Messmer, K Yasojima, KR Bales, KZ Bourne, M Guglielmotto, M Shukla, NP Seeram, NP Seeram, NT HoshinoT, OA Olajide, OA Olajide, RK Castellani, S Ahmed, S Camandola, S Sinha, SI Lee, T Decker, TJ Montine, V Buggia-Prevot, Y Farbood, Y Luo   +34 more
core   +1 more source

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]

, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Fernando B, Garg ML, Guillemin GJ, Hone E, Jayatunga DPW, Khaira H, Lunelli T, Martins RN, Singh H, Verdile G   +9 more
core   +2 more sources

Gut microbiota shifts and short‐chain fatty acids alterations in pediatric epilepsy patients on a Mediterranean ketogenic diet

Epileptic Disorders, EarlyView.
Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli, Evdokia K. Mitsou, Mary Yannakoulia, Evangelia Intze, Konstantinos C. Mountzouris, Smaragdi Fessatou, Achilleas Attilakos, Adamantini Kyriacou, Argyrios Dinopoulos   +8 more
wiley   +1 more source

Moderate intake of red wine promotes a significant increase of phenolic metabolites in human faeces [PDF]

, 2015
With the final aim of ascertaining consistent data about the changes of phenolic metabolites in faeces after a regular wine consumption, the present paper compiles the data from two previous human intervention studies: a) a pilot study (n = 8), that ...
Bartolomé, Begoña, Jiménez-Girón, Ana, Martín-Álvarez, Pedro J., Moreno-Arribas, M. Victoria, Muñoz-González, Irene   +4 more
core   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source