Results 81 to 90 of about 1,427 (175)

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Nature Communications, 2019
Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a ...
Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, Becca V. Baby, Bindu Hegde, Niranjan G. Kotla, Ankita A. Hiwale, Taslimarif Saiyed, Paresh Patel, Matam Vijay-Kumar, Morgan G. I. Langille, Gavin M. Douglas, Xi Cheng, Eric C. Rouchka, Sabine J. Waigel, Gerald W. Dryden, Houda Alatassi, Huang-Ge Zhang, Bodduluri Haribabu, Praveen K. Vemula, Venkatakrishna R. Jala   +20 more
doaj   +1 more source

Targeting aging with urolithin A in humans: A systematic review

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, AH, Lim, XK, Khoo, AL, Sandalova, E, Guan, L, Feng, L, Maier, AB   +6 more
openaire   +3 more sources

Urolithin [PDF]

, 2020
openaire   +1 more source

Fucus vesiculosus Polysaccharide-Based Solid Dispersions Enhance Aqueous Dispersion and Gut Microbial Biotransformation of Ellagic Acid

Foods
Ellagic acid (EA) is a food-derived polyphenol with multiple biological activities, but its poor water solubility and aggregation in aqueous systems limit its accessibility to gut microorganisms.
Rui-Bo Jia, Dapei Ou, Fenghua Liang, Zhao-Rong Li, Jinsong Wang, Chunxia Zhou, Pengzhi Hong   +6 more
doaj   +1 more source

Anti-Atherogenic Actions of Pomegranate Polyphenol Punicalagin and Its Metabolites: In Vitro Effects on Vascular Cells and In Vivo Atheroprotection by Urolithin A via Anti-Inflammatory and Plaque-Stabilising Mechanisms. [PDF]

Antioxidants (Basel)
Alalawi S, Rifqi D, Alhamadi A, Alotibi R, Alradi F, Alshehri N, Chan YH, Chen J, Albalawi F, Taha S, Al-Mahrami N, Guschina IA, Hughes TR, Ramji DP.   +13 more
europepmc   +1 more source

Epigenetic Modulators: Role of Gut Microbiome in Transformation of Nutrient Bioactives and Host Gene Regulation. [PDF]

Cells
Edkaidek H, Dahiya D, Nigam PS.
europepmc   +1 more source

Distinct classes of gut bacterial molybdenum-dependent enzymes produce urolithins. [PDF]

Proc Natl Acad Sci U S A
Bae M, Dong X, Avila-Pacheco J, Nguyen QD, Inyama F, Hill-Maini V, Clish CB, Balskus EP.   +7 more
europepmc   +1 more source

Phytochemical Diversity of <i>Punica granatum</i> L. and Its Multi-Target Biological Functions. [PDF]

Nutrients
Kobylińska Z, Bochno A, Och E, Kotula M, Kielar P, Galiniak S, Mołoń M.   +6 more
europepmc   +1 more source

Metabolic fate of rambutan (<i>Nephelium lappaceum</i> L.) peel polyphenols following oral administration in rats. [PDF]

Food Chem X
Liu Q, Biao W, Duan X, Zhong Y, Ma Q, Sun L, Zhuang Y.   +6 more
europepmc   +1 more source

Impact of the Combination of Epigallocatechin Gallate and Ellagic Acid Supplemented with Ketone Bodies on Energetic Restoration of Mitochondrial Dysfunction and Metabolic Inefficiencies in Patients with Multiple Sclerosis: A Review. [PDF]

Int J Mol Sci
de la Rubia Ortí JE, Roig-Soriano A, Carrera-Juliá S, Castelló-Guillen A, Machado M, García-Villalba R, Alarcón-Jiménez J, de Bernardo N, Benlloch M.   +8 more
europepmc   +1 more source