Results 31 to 40 of about 2,467 (216)

Do Pomegranate Hydrolyzable Tannins and Their Derived Metabolites Provide Relief in Osteoarthritis? Findings from a Scoping Review

Molecules, 2022
Osteoarthritis (OA) is the most common form of arthritis affecting both the elderly and the middle-aged population. Although various therapeutics have been developed to arrest the structural deterioration of cartilage, the current treatments are limited ...
Marco Govoni, Francesca Danesi
doaj   +1 more source

Urolithin A, C, and D, but not iso‐urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

Molecular Nutrition & Food Research, 2016
ScopeUrolithins (Uro) are ellagic acid (EA)‐derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary human adipocytes and hepatoma Huh7 cells.Methods and resultsUroA, UroB, UroC, UroD ...
Kang, Inhae, Kim, YongEun, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Chung, Soonkyu   +4 more
openaire   +3 more sources

Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme

Metabolites, 2020
Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are
Rajbir Singh, Sandeep Chandrashekharappa, Praveen Kumar Vemula, Bodduluri Haribabu, Venkatakrishna Rao Jala   +4 more
doaj   +1 more source

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]

, 2012
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
A Gil-Izquierdo, A Gonzalez-Sarrias, A Perez-Vicente, A Petermann, Alan Crozier, AM Aura, B Holst, BN Singh, C Manach, C Parr, C Zhao, Chris I. R. Gill, Derek Stewart, DY Shin, EM Brown, EM Coates, Emma M. Brown, FJ Reyes-Zurita, FJB van Duijnhoven, G Borges, G Lala, G Williamson, Gema Pereira-Caro, GJ McDougall, GJ McDougall, Gordon J. McDougall, Ian Rowland, IT Johnson, J Ferlay, J van Duynhoven, JR Pearson, JW Yun, LA Boyd, LS Adams, M Jenner A, M Sharma, Masaru Katoh, MJ Bermudez-Soto, MJ McCann, NP Seeram, P Ramnani, Pamela Magee, PDS Spada, Philip Allsopp, PN Chen, PS Makena, R González-Barrio, Rocio González-Barrio, S Ramos, S Roowi, S Thomasset, SJ Duthie, SR Sahasrabudhe, YZ Hashim   +53 more
core   +3 more sources

The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut–Brain Axis

Foods, 2023
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods, such as pomegranates, berries, and nuts. The consumption of ETs has often been associated with positive effects on many pathologies, including cardiovascular ...
Roxana Banc, Marius Emil Rusu, Lorena Filip, Daniela-Saveta Popa   +3 more
doaj   +1 more source

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +2 more sources

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, 2023
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles.
James Melrose
doaj   +1 more source

Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors

Scientific Reports, 2021
A series of urolithins derivatives were designed and synthesized, and their structures have been confirmed by 1H NMR, 13C NMR, and HR-MS. The inhibitory activity of these derivatives on phosphodiesterase II (PDE2) was thoroughly studied with 3-hydroxy-8 ...
Long Tang, Jianchun Jiang, Guoqiang Song, Yajing Wang, Ziheng Zhuang, Ying Tan, Yan Xia, Xianfeng Huang, Xiaoqing Feng   +8 more
doaj   +1 more source

Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria [PDF]

, 2010
Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for the therapy and prophylaxis of malaria.
Mario Dell'Agli, Germana V Galli, Michela Bulgari, Nicoletta Basilico, Sergio Romeo, Deepak Bhattacharya, Donatella Taramelli, Enrica Bosisio   +7 more
core   +1 more source

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

Herba Polonica, 2020
Fireweed (Epilobium angustifolium L.) is a well-known medicinal plant traditionally used in the treatment of urogenital diseases, stomach and liver disorders, skin problems, etc. E.
Dreger Mariola, Adamczak Artur, Seidler-Łożykowska Katarzyna, Wielgus Karolina   +3 more
doaj   +1 more source