Results 11 to 20 of about 1,721 (201)

In Silico and In Vitro Study of Antioxidant Potential of Urolithins

Antioxidants, 2023
In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA ...
Emanuela Marchese, Valentina Orlandi, Federica Turrini, Isabella Romeo, Raffaella Boggia, Stefano Alcaro, Giosuè Costa   +6 more
doaj   +4 more sources

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

Molecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni, Pedro Mena, Monia Cito, Federica Fantuzzi, Riccardo C. Bonadonna, Furio Brighenti, Alessandra Dei Cas, Daniele Del Rio   +7 more
doaj   +2 more sources

Urolithins and their possible implications for diabetic kidney

European Journal of Translational and Clinical Medicine, 2022
The increasing prevalence of diabetic kidney disease (DKD), a common complication of type 1 and type 2 diabetes, is becoming a leading risk factor of developing end stage renal disease (ESRD). The multiple mechanisms involved in renal tissue damage are a challenge for effective targeted therapy.
Milena Kotewicz, Barbara Lewko
openaire   +4 more sources

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
Mena P., Dall'Asta M., Calani L., Brighenti F., Del Rio D.   +4 more
core   +6 more sources

Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Oxidative stress is a state of excess of prooxidative species relative to the antioxidant defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this imbalance is damage of the major cellular macromolecules (carbohydrates, lipids, proteins, and DNA), which further leads to a gradual loss of tissue and organ function. It has been
Jasmina Djedjibegovic, Aleksandra Marjanovic, Emiliano Panieri, Luciano Saso   +3 more
openaire   +4 more sources

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +3 more sources

Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy [PDF]

Microbiome
Background Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease ...
Alba Rodríguez-García, Raquel Ancos-Pintado, Roberto García-Vicente, Alejandra Ortiz-Ruiz, Andrés Arroyo, Miguel Ángel Navarro, María Luz Morales, Patricia Guevara-Ramirez, Pablo Justo, Nieves López-Muñoz, José Sánchez-Pina, Rafael Alonso, María Victoria Selma, María Dolores Frutos-Lisón, Rocío García-Villalba, Francisco A. Tomás-Barberán, Rosa Ayala, Joaquín Martínez-López, María Linares   +18 more
doaj   +2 more sources

Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]

Biomedicines, 2021
Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney, Darius Fox, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung   +4 more
openaire   +4 more sources

Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety [PDF]

International Journal of Molecular Sciences, 2021
We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity.
Sanggwon Lee, Heejeong Choi, Yujin Park, Hee Jin Jung, Sultan Ullah, Inkyu Choi, Dongwan Kang, Chaeun Park, Il Young Ryu, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, Pusoon Chun, Hyung Ryong Moon   +13 more
openaire   +2 more sources

Urolithins and intestinal health

Drug Discoveries & Therapeutics, 2022
There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Lu, Chunhua, Li, Xintong, Gao, Zeyuan, Song, Yuliang, Shen, Yuemao   +4 more
openaire   +2 more sources