Results 11 to 20 of about 1,983 (203)

In Silico and In Vitro Study of Antioxidant Potential of Urolithins

open access: yesAntioxidants, 2023
In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA ...
Emanuela Marchese   +6 more
doaj   +4 more sources

Antiatherogenic effects of ellagic acid and urolithins in vitro [PDF]

open access: yesArchives of Biochemistry and Biophysics, 2016
Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors.
BERNINI, Franco   +8 more
core   +4 more sources

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

open access: yesMolecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni   +7 more
doaj   +2 more sources

Gastrointestinal stability of urolithins: an in vitro approach

open access: yesEuropean Journal of Nutrition, 2017
Purpose: Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral ...
Dall'Asta M.
core   +7 more sources

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Henrotin Y   +8 more
europepmc   +2 more sources

Urolithins and Their Precursors Ellagic Acid and Ellagitannins: Natural Sources, Extraction and Methods for Their Determination

open access: yesSeparations
In the present review, we discuss the occurrence of ellagitannins (ETs) and ellagic acid (EA) and methods for their isolation from plant materials. We summarize analytical methods, including high-performance liquid chromatography–ultraviolet (HPLC–UV ...
Christiana Mantzourani   +4 more
doaj   +2 more sources

Interactions of different urolithins with human serum albumin: Insights from fluorescence spectroscopy

open access: yes, 2023
Urolithins A, B, and C were studied for their interactions with human serum albumin using fluorescence spectroscopy, revealing distinct binding affinities and quenching behaviors.
Zelenović, Nevena   +3 more
core   +4 more sources

Urolithins and intestinal health

open access: yesDrug Discoveries & Therapeutics, 2022
There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Lu, Chunhua   +4 more
openaire   +2 more sources

Identification of ellagic acid and urolithins as natural inhibitors of Aβ25–35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking

open access: yesFrontiers in Nutrition, 2022
Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins.
Hui-Lin Li   +27 more
doaj   +1 more source

Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives

open access: yesFrontiers in Nutrition, 2022
Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create ...
Ravindran Vini   +8 more
doaj   +1 more source

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