Results 21 to 30 of about 1,427 (175)

Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme

Metabolites, 2020
Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are
Rajbir Singh, Sandeep Chandrashekharappa, Praveen Kumar Vemula, Bodduluri Haribabu, Venkatakrishna Rao Jala   +4 more
doaj   +1 more source

Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

Food & Function, 2019
Urolithin A glucuronide is deconjugated to free urolithin A in systemic inflammation.
Ávila-Gálvez, María Ángeles, GIMENEZ BASTIDA, JUAN ANTONIO, González-Sarrías, Antonio, Espín, Juan Carlos   +3 more
openaire   +5 more sources

The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut–Brain Axis

Foods, 2023
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods, such as pomegranates, berries, and nuts. The consumption of ETs has often been associated with positive effects on many pathologies, including cardiovascular ...
Roxana Banc, Marius Emil Rusu, Lorena Filip, Daniela-Saveta Popa   +3 more
doaj   +1 more source

Urolithin A, C, and D, but not iso‐urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

Molecular Nutrition & Food Research, 2016
ScopeUrolithins (Uro) are ellagic acid (EA)‐derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary human adipocytes and hepatoma Huh7 cells.Methods and resultsUroA, UroB, UroC, UroD ...
Kang, Inhae, Kim, YongEun, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Chung, Soonkyu   +4 more
openaire   +3 more sources

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, 2023
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles.
James Melrose
doaj   +1 more source

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist

Metabolites, 2018
Urolithins (e.g., UroA and B) are gut microbiota-derived metabolites of the natural polyphenol ellagic acid. Urolithins are associated with various health benefits, including attenuation of inflammatory signaling, anti-cancer effects and repression of ...
Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew   +3 more
doaj   +1 more source

Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors

Scientific Reports, 2021
A series of urolithins derivatives were designed and synthesized, and their structures have been confirmed by 1H NMR, 13C NMR, and HR-MS. The inhibitory activity of these derivatives on phosphodiesterase II (PDE2) was thoroughly studied with 3-hydroxy-8 ...
Long Tang, Jianchun Jiang, Guoqiang Song, Yajing Wang, Ziheng Zhuang, Ying Tan, Yan Xia, Xianfeng Huang, Xiaoqing Feng   +8 more
doaj   +1 more source

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

Herba Polonica, 2020
Fireweed (Epilobium angustifolium L.) is a well-known medicinal plant traditionally used in the treatment of urogenital diseases, stomach and liver disorders, skin problems, etc. E.
Dreger Mariola, Adamczak Artur, Seidler-Łożykowska Katarzyna, Wielgus Karolina   +3 more
doaj   +1 more source

Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review

Molecules, 2020
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA).
Dmitry D. Evtyugin, Sandra Magina, Dmitry V. Evtuguin   +2 more
doaj   +1 more source

Urolithins: Promising nutritional interventions for mild cognitive impairment

Journal of Functional Foods
Urolithins, a class of metabolites produced by the gut microbiota from dietary ellagic acid and ellagitannins, are abundant in various medicinal plants and foods, such as the formulation triphala, pomegranates, walnuts, and strawberries.
Wenjun Wang, Cai Rangji, Nanjia Cairang, Yi Ding, Yi Zhang, Renqing Duojie, Zhengxiang Zhang   +6 more
doaj   +1 more source