Results 21 to 30 of about 1,721 (201)
Frontiers in Nutrition, 2022 Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins.
Hui-Lin Li +27 more
doaj +1 more source
Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives
Frontiers in Nutrition, 2022 Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create ...
Ravindran Vini +8 more
doaj +1 more source
Journal of Chemical Research, 2023 Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts.
Hecheng Wang +6 more
doaj +1 more source
Journal of Agricultural and Food Chemistry, 2023 Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut Enterocloster species under anaerobic conditions. Urolithin G (3,4,8-trihydroxy urolithin) was identified by 1H NMR,
David Beltrán +7 more
openaire +3 more sources
Mitophagy Activation by Urolithin A to Target Muscle Aging
Calcified Tissue International, 2023 AbstractThe age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are tissues with high metabolic requirements, and contain rich mitochondria supply to support ...
Julie Faitg +3 more
openaire +2 more sources
Urolithin A alleviates neuropathic pain and activates mitophagy
Molecular Pain, 2023 Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting the
Chenyi Wang +6 more
openaire +2 more sources
Urolithins: an update on their metabolism, bioactivity and associated gut microbiota
, 2022 Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins and ellagic acid, are discovered by the research group in humans almost 20 years ago.
Francisco A. Tomás-Barberán +15 more
core +1 more source
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging [PDF]
Trends in Molecular Medicine, 2021 Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored.
Davide, D'Amico +5 more
openaire +2 more sources
Food & Function, 2023 The two bacterial consortia colonized the intestine of rats and converted UM-0 (non-urolithin-producing) animals into urolithin-producing animals mimicking the UM-A and UM-B metabotypes.
Iglesias Aguirre, Carlos Eduardo +7 more
openaire +3 more sources
Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation
Food & Function, 2019 Urolithin A glucuronide is deconjugated to free urolithin A in systemic inflammation.
Ávila-Gálvez, María Ángeles +3 more
openaire +5 more sources