Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis [PDF]
BiologyUrolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang +3 more
doaj +3 more sources
Metagenomic insights into urolithin formation from rambutan rind extract by rat faecal-derived microbiome [PDF]
Applied Microbiology and BiotechnologyEllagitannins and ellagic acid are microbially converted into urolithins, metabolites associated with antioxidant, anti-inflammatory, and mitochondrial-related activities.
Wai-Kit Tow +6 more
doaj +2 more sources
The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
doaj +2 more sources
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging [PDF]
Trends in Molecular Medicine, 2021 Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored.
Davide D’Amico +2 more
exaly +3 more sources
Potential impact of urolithin A on pathways relevant to sleep health: a mini review [PDF]
Frontiers in NutritionSleep is vital to human health, and poor sleep health has been associated with numerous chronic conditions, including cardiovascular disease, obesity, depression, and type 2 diabetes. Recently, an emerging area of research has focused on the relationship
Ana Clara da C. Pinaffi-Langley +4 more
doaj +2 more sources
Altitude-Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics. [PDF]
Evol ApplABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Huang F +12 more
europepmc +2 more sources
Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments [PDF]
Polar ResearchExcessive and chronic inflammation can cause osteogenic dysfunction and disrupt the balance of the osteoimmune microenvironment, thereby increasing the risk of fracture non-union.
Jinwu Bai +7 more
doaj +2 more sources
Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro [PDF]
Animals, 2021 Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested.
Élisa Fonseca +6 more
doaj +4 more sources
Functionalized hydrogels of CeO2 and Urolithin A synergistically scavenge ROS and activate mitophagy for cartilage repair [PDF]
Materials Today BioIn recent years, CeO2 nanoparticles are promising biomaterials due to their excellent biocompatibility and antioxidant properties. This study utilizes a methacrylated gelatin (GelMA) hydrogel platform to construct a dual-functional composite material ...
Chunhui Ma +5 more
doaj +2 more sources
Urolithin A blocks colorectal cancer progression by AKT1 inhibition–driven immune activation [PDF]
Scientific ReportsColorectal cancer (CRC) is one of the most common and lethal malignancies worldwide, with its initiation and progression closely linked to metabolic reprogramming, abnormal cell proliferation, and immune evasion.
Ziquan Sun +10 more
doaj +2 more sources