Results 1 to 10 of about 3,422 (114)

Fucus vesiculosus Polysaccharide-Based Solid Dispersions Enhance Aqueous Dispersion and Gut Microbial Biotransformation of Ellagic Acid [PDF]

Foods
Ellagic acid (EA) is a food-derived polyphenol with multiple biological activities, but its poor water solubility and aggregation in aqueous systems limit its accessibility to gut microorganisms.
Rui-Bo Jia, Dapei Ou, Fenghua Liang, Zhao-Rong Li, Jinsong Wang, Chunxia Zhou, Pengzhi Hong   +6 more
doaj   +2 more sources

RETRACTED: Kshirsagar et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease. Cells 2022, 11, 2660 [PDF]

Cells
The journal retracts the article titled “A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease” [...]
Sudhir Kshirsagar, Rainier Vladlen Alvir, Jangampalli Adi Pradeepkiran, Ashly Hindle, Murali Vijayan, Bhagavathi Ramasubramaniam, Subodh Kumar, Arubala P. Reddy, P. Hemachandra Reddy   +8 more
doaj   +2 more sources

Urolithin A has antiplatelet effects in contrast to its glucuronide, urolithin B, and isourolithin A [PDF]

Frontiers in Cardiovascular Medicine
IntroductionConsumption of dietary ellagitannins has been suggested to have protective effects against cardiovascular disease, likely due to the colonic formation of urolithins and their subsequent systemic absorption.
Alina Soloviova, Alina Soloviova, Marcel Hrubša, Carlos J. García, Zuzana Lomozová, Francisco A. Tomás-Barberán, Přemysl Mladěnka   +6 more
doaj   +2 more sources

Metagenomic insights into urolithin formation from rambutan rind extract by rat faecal-derived microbiome [PDF]

Applied Microbiology and Biotechnology
Ellagitannins and ellagic acid are microbially converted into urolithins, metabolites associated with antioxidant, anti-inflammatory, and mitochondrial-related activities.
Wai-Kit Tow, Cindy Shuan Ju Teh, Chien Wei Ooi, Ronald F. S. Lee, Maalini Krishnasamy, Uma Devi Palanisamy, Usha Sundralingam   +6 more
doaj   +2 more sources

Potential impact of urolithin A on pathways relevant to sleep health: a mini review [PDF]

Frontiers in Nutrition
Sleep is vital to human health, and poor sleep health has been associated with numerous chronic conditions, including cardiovascular disease, obesity, depression, and type 2 diabetes. Recently, an emerging area of research has focused on the relationship
Ana Clara da C. Pinaffi-Langley, Faris M. Zuraikat, Faris M. Zuraikat, Marie-Pierre St-Onge, Andriy Yabluchanskiy   +4 more
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A Novel Streptococcus thermophilus FUA329 Isolated from Human Breast Milk Capable of Producing Urolithin A from Ellagic Acid

Foods, 2022
Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people. Strains capable of producing urolithin A from ellagic acid have the hope of becoming the next-generation probiotics.
Qitong Liu, Shu Liu, Qinwen Ye, Xiaoyue Hou, Guang Yang, Jing Lu, Yang Hai, Juan Shen, Yaowei Fang   +8 more
doaj   +1 more source

Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells

Biochemistry and Biophysics Reports, 2021
Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria.
Hidehiko Kikuchi, Kaori Harata, Harishkumar Madhyastha, Futoshi Kuribayashi   +3 more
doaj   +1 more source

RETRACTED: A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease

Cells, 2022
In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar, Rainier Vladlen Alvir, Jangampalli Adi Pradeepkiran, Ashly Hindle, Murali Vijayan, Bhagavathi Ramasubramaniam, Subodh Kumar, Arubala P. Reddy, P. Hemachandra Reddy   +8 more
doaj   +1 more source

Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase

Molecules, 2022
Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus.
Mengjie Xiao, Fei Cao, Tao Huang, Yun-Sang Tang, Xin Zhao, Pang-Chui Shaw   +5 more
doaj   +1 more source

An in vitro investigation of the effects of urolithins A and B on low-density lipoprotein uptake and its regulatory genes

Archives of Medical Science, 2023
Introduction This study aimed to evaluate the possible role of urolithin A (UA) and urolithin B (UB) on the mRNA expression levels of LDL receptor (LDLR) and PSCK9 genes, and also of the uptake of LDL particles in HepG2 cells.
Shiva Ganjali, Maryam Matbou Riahi, Khadijeh Mahboobnia, Milad Iranshahy, Maciej Banach, Ali Jangjoo, Sorour Ashari, Zahra Tayarani-Najaran, Amirhossein Sahebkar   +8 more
doaj   +1 more source