Results 21 to 30 of about 3,740 (205)

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

Brazilian Journal of Medical and Biological Research, 2018
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor.
Zhenpeng Qiu, Junxuan Zhou, Cong Zhang, Ye Cheng, Junjie Hu, Guohua Zheng   +5 more
doaj   +2 more sources

Urolithin-C Suppresses Inflammation by Blocking NF-κB Signaling Pathway in LPS-Induced RAW 264.7 Macrophages

Journal of Inflammation Research
Vani Karadi Manjappa,1,2,* Manjula Mavathuru Venkatappa,3,* Deepadarshan Urs,4 Suliphuldevara Mathada Basavarajaiah,5 Shivakumar Venkataramaiah,3 Sanjana Bai Shivramsingh Mahendranathsingh,1 Sushma Mohan,1 Hunase Rajaiah Pushpavathi,4 ...
Manjappa VK, Venkatappa MM, Urs D, Basavarajaiah SM, Venkataramaiah S, Mahendranathsingh SBS, Mohan S, Pushpavathi HR, Krishnappa DK, Sannaningaiah D   +9 more
doaj   +1 more source

Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy

Microbiome
Background Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease ...
Alba Rodríguez-García, Raquel Ancos-Pintado, Roberto García-Vicente, Alejandra Ortiz-Ruiz, Andrés Arroyo, Miguel Ángel Navarro, María Luz Morales, Patricia Guevara-Ramirez, Pablo Justo, Nieves López-Muñoz, José Sánchez-Pina, Rafael Alonso, María Victoria Selma, María Dolores Frutos-Lisón, Rocío García-Villalba, Francisco A. Tomás-Barberán, Rosa Ayala, Joaquín Martínez-López, María Linares   +18 more
doaj   +2 more sources

Correlation between intestinal microbiota and urolithin metabolism in a human walnut dietary intervention

BMC Microbiology
This study is to investigate the relationship between the intestinal microbiota and urine levels of the ellagic acid-derived polyphenols, the urolithins, in a cohort of subjects following a three-week walnut dietary intervention.
Huijia Liu, John W. Birk, Anthony A. Provatas, Haleh Vaziri, Nuoxi Fan, Daniel W. Rosenberg, Raad Z. Gharaibeh, Christian Jobin   +7 more
doaj   +2 more sources

Determination of Urolithin A in Health Products by Ultra-High-Performance Liquid Chromatography

Molecules
This study establishes and validates a novel ultra-high-performance liquid chromatography (UHPLC) method for the determination of urolithin A content in health products, a bioactive compound with potential anti-aging properties.
Yue E, Zhuang Wang, Jiahui Nie
doaj   +2 more sources

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats [PDF]

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +2 more sources

Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]

Biomedicines, 2021
Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney, Darius Fox, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung   +4 more
openaire   +4 more sources

Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety [PDF]

International Journal of Molecular Sciences, 2021
We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity.
Sanggwon Lee, Heejeong Choi, Yujin Park, Hee Jin Jung, Sultan Ullah, Inkyu Choi, Dongwan Kang, Chaeun Park, Il Young Ryu, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, Pusoon Chun, Hyung Ryong Moon   +13 more
openaire   +2 more sources

Urolithins and intestinal health

Drug Discoveries & Therapeutics, 2022
There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Lu, Chunhua, Li, Xintong, Gao, Zeyuan, Song, Yuliang, Shen, Yuemao   +4 more
openaire   +2 more sources

First Reported Human Cases of Urolithin A Renal Calculi [PDF]

Kidney International Reports
Sara L. Best, Valentinas Gruzdys, Mark White, Natalia Gromadzka, Benjamin Owen, Yongbo Zhang, John R. Asplin   +6 more
doaj   +2 more sources