Results 21 to 30 of about 354 (136)

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

Antioxidants, 2020
Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries.
Guillermo Cásedas, Francisco Les, Carmen Choya-Foces, Martín Hugo, Víctor López   +4 more
doaj   +1 more source

Design, synthesis, and biological evaluation of urolithin derivatives as potential phosphodiesterase II inhibitors

Journal of Chemical Research, 2023
Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts.
Hecheng Wang, Long Tang, Wanhui Di, Feng Yan, Xianfeng Huang, Xiaoqing Feng, Guoqiang Song   +6 more
doaj   +1 more source

The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro

Frontiers in Pharmacology, 2021
Scope: Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical ...
Nina A. Hering, Julia Luettig, Britta Jebautzke, Jörg D. Schulzke, Rita Rosenthal   +4 more
doaj   +1 more source

Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Biology
Urolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang, Ren Zhou, Yong Ruan, Shuhao Fan   +3 more
doaj   +1 more source

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

Frontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Yaowei Fang, Yaowei Fang, Yaowei Fang, Guang Yang, Guang Yang, Guang Yang, Xiaoyue Hou, Xiaoyue Hou, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao, Yaling Zhao, Yaling Zhao, Shu Liu, Shu Liu, Shu Liu   +20 more
doaj   +1 more source

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

Molecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni, Pedro Mena, Monia Cito, Federica Fantuzzi, Riccardo C. Bonadonna, Furio Brighenti, Alessandra Dei Cas, Daniele Del Rio   +7 more
doaj   +1 more source

NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal Enterocloster Species

Journal of Agricultural and Food Chemistry, 2023
Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut Enterocloster species under anaerobic conditions. Urolithin G (3,4,8-trihydroxy urolithin) was identified by 1H NMR,
David Beltrán, María D. Frutos-Lisón, Rocío García-Villalba, José E. Yuste, Victor García, Juan C. Espín, María V. Selma, Francisco A. Tomás-Barberán   +7 more
openaire   +3 more sources

Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro

Animals, 2021
Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested.
Élisa Fonseca, Carla Cruz Marques, Jorge Pimenta, Joana Jorge, Maria Conceição Baptista, Ana Cristina Gonçalves, Rosa M. L. N. Pereira   +6 more
doaj   +1 more source

Mitophagy Activation by Urolithin A to Target Muscle Aging

Calcified Tissue International, 2023
AbstractThe age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are tissues with high metabolic requirements, and contain rich mitochondria supply to support ...
Julie Faitg, Davide D’Amico, Chris Rinsch, Anurag Singh   +3 more
openaire   +3 more sources

Urolithin A attenuates osteoclast differentiation and compensates for ovariectomy-induced bone loss in mice by inhibiting PI3K/AKT/mTOR signaling pathway

Phytomedicine Plus
Backgrounds and purposes: Osteoporosis (OP) is a debilitating illness distinguished by a reduction in bone density and microstructure, which leads to fragility, fracture risk, and increased mortality, particularly in the elderly and postmenopausal women.
Wenyun Zhou, Weijun Zhou, Zibin Zhou, Yonghao Bi, Zhigao Zhou, Shaozhe Chen, Zihong Lin, Jiajie Ye, Gang Xie, Wenjie Liu, Dantao Xie, Zhen Lian, Ruiwu Zheng, Xianghua Hu, Xinjia Wang, Guixin Yuan, Guanfeng Yao   +16 more
doaj   +1 more source