Results 11 to 20 of about 114,628,527 (155)

Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Biology
Urolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang, Ren Zhou, Yong Ruan, Shuhao Fan   +3 more
doaj   +2 more sources

Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer [PDF]

Frontiers in Pharmacology
BackgroundThe natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer.
Vladimir Rogovskii, Vladimir Rogovskii, Vladimir V. Murugin, Vladimir V. Murugin, Nikolay Vorobyev, Nikolay Vorobyev, Sergey Popov, Nikolay Sturov, Alexey Krasheninnikov, Alexander Morozov, Marina Prokhorova   +10 more
doaj   +2 more sources

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent [PDF]

Antioxidants, 2020
Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries.
Guillermo Cásedas, Francisco Les, Carmen Choya-Foces, Martín Hugo, Víctor López   +4 more
doaj   +2 more sources

Urolithin-C Suppresses Inflammation by Blocking NF-κB Signaling Pathway in LPS-Induced RAW 264.7 Macrophages

Journal of Inflammation Research
Vani Karadi Manjappa,1,2,* Manjula Mavathuru Venkatappa,3,* Deepadarshan Urs,4 Suliphuldevara Mathada Basavarajaiah,5 Shivakumar Venkataramaiah,3 Sanjana Bai Shivramsingh Mahendranathsingh,1 Sushma Mohan,1 Hunase Rajaiah Pushpavathi,4 ...
Manjappa VK, Venkatappa MM, Urs D, Basavarajaiah SM, Venkataramaiah S, Mahendranathsingh SBS, Mohan S, Pushpavathi HR, Krishnappa DK, Sannaningaiah D   +9 more
doaj   +1 more source

Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor

Brain, Behavior, & Immunity - Health, 2020
Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain.
Sijie Tan, Wen Han Tong, Ajai Vyas
doaj   +2 more sources

Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy

Microbiome
Background Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease ...
Alba Rodríguez-García, Raquel Ancos-Pintado, Roberto García-Vicente, Alejandra Ortiz-Ruiz, Andrés Arroyo, Miguel Ángel Navarro, María Luz Morales, Patricia Guevara-Ramirez, Pablo Justo, Nieves López-Muñoz, José Sánchez-Pina, Rafael Alonso, María Victoria Selma, María Dolores Frutos-Lisón, Rocío García-Villalba, Francisco A. Tomás-Barberán, Rosa Ayala, Joaquín Martínez-López, María Linares   +18 more
doaj   +2 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf-1/ERK1/2/PINK1 Signaling Axis. [PDF]

Adv Sci (Weinh)
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Zhang L, Li J, Zhang H, Qin Q, Huang Y, Tian X, Sun C, Li B, Wang Z, Zhang X.   +9 more
europepmc   +2 more sources

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Henrotin Y, Florin A, Sanchez C, Centonze P, Coelho TP, Bekisz S, Dubuc JE, Galand O, Lambert C.   +8 more
europepmc   +2 more sources

Correlation between intestinal microbiota and urolithin metabolism in a human walnut dietary intervention

BMC Microbiology
This study is to investigate the relationship between the intestinal microbiota and urine levels of the ellagic acid-derived polyphenols, the urolithins, in a cohort of subjects following a three-week walnut dietary intervention.
Huijia Liu, John W. Birk, Anthony A. Provatas, Haleh Vaziri, Nuoxi Fan, Daniel W. Rosenberg, Raad Z. Gharaibeh, Christian Jobin   +7 more
doaj   +2 more sources

Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography [PDF]

, 2023
Urolithins are gut microbiota metabolites produced in humans after consuming foods containing ellagitannins and ellagic acid. Three urolithin metabotypes have been reported for different individuals depending on the final urolithins produced.
José Bernal, Francisco A. Tomás-Barberán, Ana M. Ares, Toribio Recio, Laura, García Villalba, Rocío, Ana M. Ares (14526876), Tomás Barberán, Francisco A., Yusuf Althobaiti (12519864), Villalgordo, Jose M., Toribio, Laura, Jose M. Villalgordo (2747317), Bernal del Nozal, José, Rocío García-Villalba (2099278), Ares Sacristán, Ana María, Bernal, José, Ares, Ana M., García-Villalba, Rocío, Laura Toribio (14526879), José Bernal (14526882), Rocío García-Villalba, Althobaiti, Yusuf, Laura Toribio, Yusuf Althobaiti, Tomás Barberán, Francisco, Francisco A. Tomás-Barberán (2099284), Jose M. Villalgordo   +25 more
core   +1 more source