Results 11 to 20 of about 4,964 (226)
Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro [PDF]
Animals, 2021 Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested.
Élisa Fonseca +6 more
doaj +4 more sources
Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]
Biomedicines, 2021 Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney +4 more
openaire +4 more sources
Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety [PDF]
International Journal of Molecular Sciences, 2021 We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity.
Sanggwon Lee +13 more
openaire +2 more sources
Urolithins and intestinal health
Drug Discoveries & Therapeutics, 2022 There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Chunhua, Lu +4 more
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Effect of Urolithin A on Bovine Sperm Capacitation and In Vitro Fertilization
AnimalsReactive oxygen species (ROS) play a critical role in the functional competence of sperm cells. Conversely, excessive generation of ROS can impair sperm function, including their fertilization ability.
Manuela Jorge +8 more
doaj +3 more sources
Archives of Medical Science, 2023 Introduction This study aimed to evaluate the possible role of urolithin A (UA) and urolithin B (UB) on the mRNA expression levels of LDL receptor (LDLR) and PSCK9 genes, and also of the uptake of LDL particles in HepG2 cells.
Shiva Ganjali +8 more
doaj +1 more source
Journal of Agricultural and Food Chemistry, 2023 Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut Enterocloster species under anaerobic conditions. Urolithin G (3,4,8-trihydroxy urolithin) was identified by 1H NMR,
David Beltrán +7 more
openaire +3 more sources
Mitophagy Activation by Urolithin A to Target Muscle Aging
Calcified Tissue International, 2023 AbstractThe age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are tissues with high metabolic requirements, and contain rich mitochondria supply to support ...
Julie Faitg +3 more
openaire +2 more sources
Urolithin A alleviates neuropathic pain and activates mitophagy
Molecular Pain, 2023 Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting ...
Chenyi Wang +6 more
openaire +2 more sources
Frontiers in Pharmacology, 2020 Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins.
Linda Volpp +5 more
doaj +1 more source