Results 31 to 40 of about 4,964 (226)

Urolithin A, C, and D, but not iso‐urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

Molecular Nutrition & Food Research, 2016
ScopeUrolithins (Uro) are ellagic acid (EA)‐derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary human adipocytes and hepatoma Huh7 cells.Methods and resultsUroA, UroB, UroC, UroD ...
Kang, Inhae, Kim, YongEun, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Chung, Soonkyu   +4 more
openaire   +3 more sources

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10^−/− Mice

Pathogens, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat   +3 more
doaj   +1 more source

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +2 more sources

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells [PDF]

, 2015
Walnuts have been gathering attention for their health-promoting properties. They are rich in polyphenols, mainly ellagitannins (ETs) that after consumption are hydrolyzed to release ellagic acid (EA).
Ciudad i Gómez, Carlos Julián, Izquierdo Pulido, Maria, Noé Mata, Verónica, Sánchez González, Claudia Alejandra   +3 more
core   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source

Urolithin A targets the AKT/WNK1 axis to induce autophagy and exert anti-tumor effects in cholangiocarcinoma

Frontiers in Oncology, 2022
Urolithin A (UA; 3,8-dihydroxybenzo[c]chromen-6-one), a metabolite generated by intestinal bacteria during the biotransformation of ellagitannins, has gained considerable attention in treating several cancers.
Hidenori Sahashi, Akihisa Kato, Michihiro Yoshida, Kazuki Hayashi, Itaru Naitoh, Yasuki Hori, Makoto Natsume, Naruomi Jinno, Kenta Kachi, Go Asano, Tadashi Toyohara, Yusuke Kito, Sudhakar Ammanamanchi, Hiromi Kataoka   +13 more
doaj   +1 more source

Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED Study [PDF]

, 2017
The beneficial impact of walnuts on human health has been attributed to their unique chemical composition. In order to characterize the dietary walnut fingerprinting, spot urine samples from two sets of 195 (training) and 186 (validation) individuals ...
Andrés Lacueva, Ma. Cristina, Corella Piquer, Dolores, Estruch Riba, Ramon, Fitó Colomer, Montserrat, Garcia Aloy, Mar, Llorach, Rafael, Martínez-González, Miguel Ángel, 1957-, Ros Rahola, Emilio, Salas Salvadó, Jordi, Tulipani, Sara, Urpí Sardà, Mireia   +10 more
core   +1 more source

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

Brazilian Journal of Medical and Biological Research, 2018
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor.
Zhenpeng Qiu, Junxuan Zhou, Cong Zhang, Ye Cheng, Junjie Hu, Guohua Zheng   +5 more
doaj   +1 more source

Perspective: Metabotyping-A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease [PDF]

, 2019
Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease.
Agneta, Rostgaard-Hansen,,, Anne, Tjønneland,,, Claudia, Vetrani,,, Cristina, Andres-Lacueva,,, Estanyol, Torres, Núria,, Gabriele, Riccardi,,, Giuseppina, Costabile,,, Jens, Nielsen,,, Jytte, Halkjær,,, Lin, Shi,,, Lingqun, Ye, Ye,, Palmnäs, Marie, Brunius, Carl,, Raul, Zamora-Ros,,, Raúl, González-Domínguez,,, Rikard, Landberg,,, Rosalba, Giacco,,   +15 more
core   +1 more source

Design, synthesis, and biological evaluation of urolithin derivatives as potential phosphodiesterase II inhibitors

Journal of Chemical Research, 2023
Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts.
Hecheng Wang, Long Tang, Wanhui Di, Feng Yan, Xianfeng Huang, Xiaoqing Feng, Guoqiang Song   +6 more
doaj   +1 more source