Results 31 to 40 of about 354 (136)

Antiatherogenic effects of ellagic acid and urolithins in vitro

Archives of Biochemistry and Biophysics, 2016
Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors. Ellagitannins are a class of phenolic compounds that may play a role in cardiovascular health. This work aimed to study the potential atheroprotective effects of urolithins, ellagitannin-derived gut
MELE, Laura, MENA PARRENO, Pedro Miguel, PIEMONTESE, Antonio, MARINO, VALENTINA, López Gutiérrez, Noelia, BERNINI, Franco, BRIGHENTI, Furio, ZANOTTI, Ilaria, DEL RIO, Daniele   +8 more
openaire   +3 more sources

Urolithin A alleviates neuropathic pain and activates mitophagy

Molecular Pain, 2023
Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting the
Chenyi Wang, Zizhu Wang, Shiyu Xue, Yutong Zhu, Jiahao Jin, Qiuyu Ren, Xiaodong Shi   +6 more
openaire   +2 more sources

Gut microbiota shifts and short‐chain fatty acids alterations in pediatric epilepsy patients on a Mediterranean ketogenic diet

Epileptic Disorders, EarlyView.
Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli, Evdokia K. Mitsou, Mary Yannakoulia, Evangelia Intze, Konstantinos C. Mountzouris, Smaragdi Fessatou, Achilleas Attilakos, Adamantini Kyriacou, Argyrios Dinopoulos   +8 more
wiley   +1 more source

Fucus vesiculosus Polysaccharide-Based Solid Dispersions Enhance Aqueous Dispersion and Gut Microbial Biotransformation of Ellagic Acid

Foods
Ellagic acid (EA) is a food-derived polyphenol with multiple biological activities, but its poor water solubility and aggregation in aqueous systems limit its accessibility to gut microorganisms.
Rui-Bo Jia, Dapei Ou, Fenghua Liang, Zhao-Rong Li, Jinsong Wang, Chunxia Zhou, Pengzhi Hong   +6 more
doaj   +1 more source

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

Antioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos, Paola Quifer-Rada, María Marhuenda-Muñoz, Camila Arancibia-Riveros, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Ana María Ruiz-León, Rosa Casas, Ramon Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Jesús Martínez-Gómez, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Rosa M. Lamuela-Raventós   +16 more
doaj   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species

npj Biofilms and Microbiomes
Urolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon, Arianna Giurleo, Lharbi Dridi, Bastien Castagner   +3 more
doaj   +1 more source

Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer

Frontiers in Pharmacology
BackgroundThe natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer.
Vladimir Rogovskii, Vladimir Rogovskii, Vladimir V. Murugin, Vladimir V. Murugin, Nikolay Vorobyev, Nikolay Vorobyev, Sergey Popov, Nikolay Sturov, Alexey Krasheninnikov, Alexander Morozov, Marina Prokhorova   +10 more
doaj   +1 more source

Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor

Brain, Behavior, & Immunity - Health, 2020
Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain.
Sijie Tan, Wen Han Tong, Ajai Vyas
doaj   +1 more source

The role of human microbiota in breast cancer pathogenesis and treatment

iMeta, EarlyView.
The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu, Xiaojia Wang, Man Li, Jing Guo, Shipeng Ning, Yi‐Zhou Gao, Xinyi Zhang, Xuli Meng, Yiding Chen, Yunxiang Zhou   +9 more
wiley   +1 more source