Results 31 to 40 of about 114,628,527 (155)

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A [PDF]

, 2011
Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice.
Tai, Akihiro, Ito, Hideyuki, Ishimoto, Hidekazu, Myojin, Yuki, Sugimoto, Yukio, Hatano, Tsutomu, Shibata, Mari   +6 more
core   +2 more sources

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

Brazilian Journal of Medical and Biological Research, 2018
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor.
Zhenpeng Qiu, Junxuan Zhou, Cong Zhang, Ye Cheng, Junjie Hu, Guohua Zheng   +5 more
doaj   +1 more source

Colonization in Newly Born: The Role of Mothers’ Urolithin Metabotypes

, 2020
The maternal-infant transmission of several urolithins through breast milk and the gut colonization of infants by the urolithin-producing bacterium Gordonibacter during their first year of life were explored.
Ana Rodríguez-Varela, Francisco A. Tomás-Barberán, Romo-Vaquero, María, García-Mantrana, Izaskun, Izaskun García-Mantrana, García-Villalba, Rocío, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Rocío García-Villalba, María Romo-Vaquero, Adrián Cortés-Martín, Rodríguez-Varela, Ana, Selma, María Victoria, María Victoria Selma, María Carmen Collado, Juan Carlos Espín, Cortés-Martín, Adrián, Collado, María Carmen   +17 more
core   +1 more source

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]

, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Singh H, Verdile G, Garg ML, Lunelli T, Martins RN, Guillemin GJ, Jayatunga DPW, Fernando B, Hone E, Khaira H   +9 more
core   +3 more sources

Urolithin A targets the AKT/WNK1 axis to induce autophagy and exert anti-tumor effects in cholangiocarcinoma

Frontiers in Oncology, 2022
Urolithin A (UA; 3,8-dihydroxybenzo[c]chromen-6-one), a metabolite generated by intestinal bacteria during the biotransformation of ellagitannins, has gained considerable attention in treating several cancers.
Hidenori Sahashi, Akihisa Kato, Michihiro Yoshida, Kazuki Hayashi, Itaru Naitoh, Yasuki Hori, Makoto Natsume, Naruomi Jinno, Kenta Kachi, Go Asano, Tadashi Toyohara, Yusuke Kito, Sudhakar Ammanamanchi, Hiromi Kataoka   +13 more
doaj   +1 more source

Novel Regioselective Synthesis of Urolithin GlucuronidesHuman Gut Microbiota Cometabolites of Ellagitannins and Ellagic Acid

, 2022
Urolithins (dibenzo-pyran-[b,d]-6 one derivatives) are human gut microbiota metabolites produced from the natural food antioxidant ellagic acid. Urolithins are better absorbed than ellagic acid and demonstrate biological activities that suggest that they
Laura Trulli (1663636), Jose M. Villalgordo (2747317), Rocío García-Villalba, Victor García (2855111), Francisco A. Tomás-Barberán, Yusuf Althobaiti, Rocío García-Villalba (2099278), Yusuf Althobaiti (12519864), Francisco A. Tomás-Barberán (2099284), Jose M. Villalgordo, Laura Trulli, Victor García   +11 more
core   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source

Design, synthesis, and biological evaluation of urolithin derivatives as potential phosphodiesterase II inhibitors

Journal of Chemical Research, 2023
Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts.
Hecheng Wang, Long Tang, Wanhui Di, Feng Yan, Xianfeng Huang, Xiaoqing Feng, Guoqiang Song   +6 more
doaj   +1 more source

Identifying brazilwood’s marker component, urolithin c, in historical textiles by surface-enhanced raman spectroscopy [PDF]

, 2021
The fugitive nature of the colorants obtained from sappanwood (Caesalpinia sappan L.) or the South American species commonly known as ‘brazilwoods’ (including other Caesalpinia species and Paubrasilia echinata (Lam.)) makes the identification of ...
Miliani C., Degano I., Romani A., Higgitt C., Doherty B., Peggie D., Colombini M. P.   +6 more
core   +1 more source

The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro

Frontiers in Pharmacology, 2021
Scope: Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical ...
Nina A. Hering, Julia Luettig, Britta Jebautzke, Jörg D. Schulzke, Rita Rosenthal   +4 more
doaj   +1 more source