Results 41 to 50 of about 114,628,527 (155)

First Reported Human Cases of Urolithin A Renal Calculi [PDF]

Kidney International Reports
Sara L. Best, Valentinas Gruzdys, Mark White, Natalia Gromadzka, Benjamin Owen, Yongbo Zhang, John R. Asplin   +6 more
doaj   +2 more sources

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

Molecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni, Pedro Mena, Monia Cito, Federica Fantuzzi, Riccardo C. Bonadonna, Furio Brighenti, Alessandra Dei Cas, Daniele Del Rio   +7 more
doaj   +1 more source

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

Frontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Yaowei Fang, Yaowei Fang, Yaowei Fang, Guang Yang, Guang Yang, Guang Yang, Xiaoyue Hou, Xiaoyue Hou, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao, Yaling Zhao, Yaling Zhao, Shu Liu, Shu Liu, Shu Liu   +20 more
doaj   +1 more source

Unlocking the Hepatoprotective Potential of Urolithin A in High-Fat Diet-Induced MASLD: Integrated Role of Oxidative Stress, Inflammation, FXR/PPAR-α, and Fibrotic Pathway. [PDF]

Cell Biochem Funct
ABSTRACT “Metabolic dysfunction–associated steatotic liver disease” (MASLD) is marked by hepatic steatosis, oxidative stress, inflammation, and fibrosis. Urolithin A (Uro A), a metabolite of ellagitannins, exhibits anti‐inflammatory, antioxidant, and metabolic regulatory activities.
Alsaykhan H, Shalaby AM, Keshk WA, Kamel SSE, Alnasser SM, Alorini M, Jaber FA, Alabiad MA, Younes AM, Abdelnour HM.   +9 more
europepmc   +2 more sources

Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro

Animals, 2021
Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested.
Élisa Fonseca, Carla Cruz Marques, Jorge Pimenta, Joana Jorge, Maria Conceição Baptista, Ana Cristina Gonçalves, Rosa M. L. N. Pereira   +6 more
doaj   +1 more source

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome. [PDF]

, 2020
Background & aims: Urolithins are microbial metabolites produced after consumption of ellagitannincontaining foods such as pomegranates and walnuts.
Espín, Juan Carlos, Andrés Lacueva, Ma. Cristina, Alasalvar, Cesarettin, Tomas-Barberan, F. A. (Francisco A.), Selma, María Victoria, Salas Salvadó, Jordi, González-Sarrías, Antonio, Örem, Asim   +7 more
core   +1 more source

Urolithin A attenuates osteoclast differentiation and compensates for ovariectomy-induced bone loss in mice by inhibiting PI3K/AKT/mTOR signaling pathway

Phytomedicine Plus
Backgrounds and purposes: Osteoporosis (OP) is a debilitating illness distinguished by a reduction in bone density and microstructure, which leads to fragility, fracture risk, and increased mortality, particularly in the elderly and postmenopausal women.
Wenyun Zhou, Weijun Zhou, Zibin Zhou, Yonghao Bi, Zhigao Zhou, Shaozhe Chen, Zihong Lin, Jiajie Ye, Gang Xie, Wenjie Liu, Dantao Xie, Zhen Lian, Ruiwu Zheng, Xianghua Hu, Xinjia Wang, Guixin Yuan, Guanfeng Yao   +16 more
doaj   +1 more source

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

Antioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos, Paola Quifer-Rada, María Marhuenda-Muñoz, Camila Arancibia-Riveros, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Ana María Ruiz-León, Rosa Casas, Ramon Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Jesús Martínez-Gómez, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Rosa M. Lamuela-Raventós   +16 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

, 2021
Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity ...
Ávila-Gálvez, María Ángeles, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos   +3 more
core   +1 more source