Results 41 to 50 of about 3,740 (205)

In Silico and In Vitro Study of Antioxidant Potential of Urolithins

Antioxidants, 2023
In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA), also known as urolithins (UROs). In order to evaluate their ability to counter the effect of oxidative
Emanuela Marchese, Valentina Orlandi, Federica Turrini, Isabella Romeo, Raffaella Boggia, Stefano Alcaro, Giosuè Costa   +6 more
openaire   +3 more sources

HIV-1 Integrase Inhibitory Effects of Major Compounds Present in CareVid™: An Anti-HIV Multi-Herbal Remedy

Life, 2022
In our continued study on the anti-HIV activity of compounds present in CareVidTM, we report the HIV-1 integrase ((HIV-1 IN) inhibitory effects of pellitorine (1), oleuropein (2), magnoflorine (3), crotepoxide (4), ent-kaurane-16β,17-diol (5 ...
Winnie Rotich, Eduard Mas-Claret, Nicholas Sadgrove, Anastasia Guantai, Guillermo F. Padilla-González, Moses K. Langat   +5 more
doaj   +1 more source

Identifying brazilwood’s marker component, urolithin c, in historical textiles by surface-enhanced raman spectroscopy [PDF]

, 2021
The fugitive nature of the colorants obtained from sappanwood (Caesalpinia sappan L.) or the South American species commonly known as ‘brazilwoods’ (including other Caesalpinia species and Paubrasilia echinata (Lam.)) makes the identification of ...
Miliani C., Degano I., Romani A., Higgitt C., Doherty B., Peggie D., Colombini M. P.   +6 more
core   +1 more source

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Frontiers in Endocrinology, 2022
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease ...
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Cláudia N. dos Santos, Regina Menezes, Regina Menezes, Regina Menezes   +15 more
doaj   +1 more source

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +2 more sources

Urolithin B, a newly identified regulator of skeletal muscle mass. [PDF]

, 2017
The control of muscle size is an essential feature of health. Indeed, skeletal muscle atrophy leads to reduced strength, poor quality of life, and metabolic disturbances.
Pierre, Nicolas, Nicolas Pierre, Ferreira, Daneel, Damien Naslain, Rodriguez, Julie, Daneel Ferreira, Francaux, Marc, Françoise Bontemps, Julie Rodriguez, Bontemps, Françoise, Marc Francaux, Louise Deldicque, Priem, Fabian, Deldicque, Louise, Naslain, Damien, Fabian Priem   +15 more
core   +1 more source

Novel Regioselective Synthesis of Urolithin GlucuronidesHuman Gut Microbiota Cometabolites of Ellagitannins and Ellagic Acid

, 2022
Urolithins (dibenzo-pyran-[b,d]-6 one derivatives) are human gut microbiota metabolites produced from the natural food antioxidant ellagic acid. Urolithins are better absorbed than ellagic acid and demonstrate biological activities that suggest that they
Laura Trulli (1663636), Jose M. Villalgordo (2747317), Rocío García-Villalba, Victor García (2855111), Francisco A. Tomás-Barberán, Yusuf Althobaiti, Rocío García-Villalba (2099278), Yusuf Althobaiti (12519864), Francisco A. Tomás-Barberán (2099284), Jose M. Villalgordo, Laura Trulli, Victor García   +11 more
core   +1 more source

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A [PDF]

, 2011
Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice.
Tai, Akihiro, Ito, Hideyuki, Ishimoto, Hidekazu, Myojin, Yuki, Sugimoto, Yukio, Hatano, Tsutomu, Shibata, Mari   +6 more
core   +2 more sources

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10^−/− Mice

Pathogens, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat   +3 more
doaj   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source