Results 61 to 70 of about 3,740 (205)

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

Molecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni, Pedro Mena, Monia Cito, Federica Fantuzzi, Riccardo C. Bonadonna, Furio Brighenti, Alessandra Dei Cas, Daniele Del Rio   +7 more
doaj   +1 more source

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

Frontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Yaowei Fang, Yaowei Fang, Yaowei Fang, Guang Yang, Guang Yang, Guang Yang, Xiaoyue Hou, Xiaoyue Hou, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao, Yaling Zhao, Yaling Zhao, Shu Liu, Shu Liu, Shu Liu   +20 more
doaj   +1 more source

Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro

Pharmaceutical Biology, 2022
L'urolithine A (UroA) peut inhiber la croissance de nombreuses cellules cancéreuses humaines, mais il n'a pas été rapporté si l'UroA inhibe les cellules de carcinome nasopharyngé (NPC). Pour explorer l'effet inhibiteur de l'UroA sur le NPC et le mécanisme potentiel in vitro.
Yang� Yang, Zhenglong Ren, Wujun Wei, Zhilong He, Youlin Deng, Zhuan Wang, Yu-Chun Fan, Jie Zhou, Lufang Jiang   +8 more
openaire   +3 more sources

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

Antioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos, Paola Quifer-Rada, María Marhuenda-Muñoz, Camila Arancibia-Riveros, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Ana María Ruiz-León, Rosa Casas, Ramon Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Jesús Martínez-Gómez, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Rosa M. Lamuela-Raventós   +16 more
doaj   +1 more source

Compositions Comprising Urolithin A And Uses Thereof In Treating Kidney Injury

, 2021
The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions
Majeti, Naga Vankata Ravi Kumar, Arora, Meenakshi, Ganugula, Raghu, Zou, Dianxiong   +3 more
core  

Urolithin A attenuates auditory cell senescence by activating mitophagy

Scientific Reports, 2022
AbstractAging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells.
Sung Il Cho, Eu-Ri Jo, Hansoo Song
openaire   +3 more sources

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Fuxiang He, Yingying Bian, Yaling Zhao, Mengjie Xia, Shu Liu, Jiajin Gui, Xiaoyue Hou, Yaowei Fang   +7 more
openaire   +2 more sources

Urolithin A attenuates osteoclast differentiation and compensates for ovariectomy-induced bone loss in mice by inhibiting PI3K/AKT/mTOR signaling pathway

Phytomedicine Plus
Backgrounds and purposes: Osteoporosis (OP) is a debilitating illness distinguished by a reduction in bone density and microstructure, which leads to fragility, fracture risk, and increased mortality, particularly in the elderly and postmenopausal women.
Wenyun Zhou, Weijun Zhou, Zibin Zhou, Yonghao Bi, Zhigao Zhou, Shaozhe Chen, Zihong Lin, Jiajie Ye, Gang Xie, Wenjie Liu, Dantao Xie, Zhen Lian, Ruiwu Zheng, Xianghua Hu, Xinjia Wang, Guixin Yuan, Guanfeng Yao   +16 more
doaj   +1 more source

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Pharmaceuticals, 2023
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis.
Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli   +12 more
doaj   +1 more source

Gut microbiota shifts and short‐chain fatty acids alterations in pediatric epilepsy patients on a Mediterranean ketogenic diet

Epileptic Disorders, EarlyView.
Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli, Evdokia K. Mitsou, Mary Yannakoulia, Evangelia Intze, Konstantinos C. Mountzouris, Smaragdi Fessatou, Achilleas Attilakos, Adamantini Kyriacou, Argyrios Dinopoulos   +8 more
wiley   +1 more source