Results 71 to 80 of about 114,628,527 (155)

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Journal of Inflammation, 2020
Background Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults.
Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang, Zhi-yong Ruan   +7 more
doaj   +1 more source

Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression

Clinical Cardiology, Volume 49, Issue 9, September 2026.
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Usamah Sayed, Zarina Nasirova, Quvonch Tursunov, Omer Qutaiba B. Allela, Lara Asim Kzar, Rajashree Panigrahi, Neeraj Bainsal   +7 more
wiley   +1 more source

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

, 2012
Numerous in vitro and in vivo studies indicate that ellagitannins exhibit anti-inflammatory, anti-atherosclerotic and anti-angiogenic activity which support their potential preventive effect against cardiovascular diseases.
Larrosa, Mar, Tomás Barberán, Francisco, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos, García-Conesa, María Teresa   +5 more
core   +1 more source

Oxidant‐ and Base‐Free Oxidative Lactonization of 2‐Arylbenzoic Acids in Two‐Molecule Photoredox System

ChemPhotoChem, Volume 10, Issue 9, September 2026.
Oxidant‐ and base‐free photoinduced oxidative lactonization of 2‐arylbenzoic acids in a two‐molecule photoredox system under an Ar atmosphere successfully provided the corresponding benzo‐3,4‐coumarins through oxidation by the protonated radical anion of 9,10‐dicyanoanthracene.
Sho Shimamura, Ryoga Hashimoto, Toshiki Furutani, Mugen Yamawaki, Hirotsugu Suzuki, Yasuharu Yoshimi   +5 more
wiley   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, Volume 3, Issue 3, Page 444-465, September 2026.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Process Optimization and Quality Evaluation of Pomegranate Juice Yogurt Fermented with Streptococcus thermophilus FUA329

Shipin gongye ke-ji
Metabolizing ellagic acid (EA) to urolithin A with numerous bioactivities significantly improve the nutritional value of food rich in EA. In the present study, Streptococcus thermophilus FUA329 was applied to prepare pomegranate juice yogurt.
Yichen HUANG, Ziyan HUA, Gewen ZHANG, Shu LIU, Xiaoyue HOU, Kexin CHI, Guang YANG, Xiang ZHOU, Yaowei FANG   +8 more
doaj   +1 more source

Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments

Food & Nutrition Research
Excessive and chronic inflammation can cause osteogenic dysfunction and disrupt the balance of the osteoimmune microenvironment, thereby increasing the risk of fracture non-union.
Jinwu Bai, Jixing Fan, Ruideng Wang, Shilong Su, Daole Hu, Xi He, Shan Gao, Fang Zhou   +7 more
doaj   +1 more source

Urolithin A Alleviates Doxorubicin-Induced Senescence in Mesenchymal Stem Cells

The accumulation of senescent cells, characterized by a pro-inflammatory secretory phenotype (SASP), metabolic dysfunction, and irreversible cell cycle arrest, is a driving force behind numerous age-related pathologies and directly undermines the ...
Kalinin, Alexander, Ekaterina Zubkova, Yelena Parfyonova, Mikhail Menshikov, Zubkova, Ekaterina, Menshikov, Mikhail, Alexander Kalinin, Parfyonova, Yelena   +7 more
core   +1 more source

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where we administer a postbiotic compound ...
Evans, Mal, Aebischer, Patrick, Fouassier, Andreane M., Blanco-Bose, William, Rinsch, Chris, D'Amico, Davide, Singh, Anurag, Auwerx, Johan, Andreux, Penelope A.   +8 more
core   +1 more source

Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells [PDF]

, 2019
Scope: Urolithin A is an anti-inflammatory and neuroprotective gut-derived metabolite from ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT-1 and autophagy in the neuroprotective activity of urolithin A are investigated.
El-Bakoush, Abdelmeneim, Olajide, Olumayokun, Harsharan Bhatia, Katola, Folashade, Velagapudi, Ravikanth, El‐Bakoush, Abdelmeneim, Olumayokun A. Olajide, Ravikanth Velagapudi, Abdelmeneim El‐Bakoush, Bhatia, Harsharan, Lepiarz, Izabela, Fiebich, Bernd L., Bhatia, Harsharan S., Katola, Folashade O., Izabela Lepiarz, Folashade O. Katola, Bernd L. Fiebich, Olajide, Olumayokun A.   +17 more
core   +1 more source