Results 81 to 90 of about 4,964 (226)

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster [PDF]

, 2017
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing.
A Rana, A Tanaka, AC Poole, AC Poole, AM Pickrell, AS Rambold, B DuBoff, C Lopez-Otin, CC Yang, CQ Scheckhuber, D Mathur, D Ryu, DC Chan, DC David, DC Rubinsztein, DJ Klionsky, DP Narendra, DR Green, DW Walker, E Beregi, E Dambroise, E Lionaki, E Owusu-Ansah, E Smirnova, E Ziviani, ES Vincow, F Demontis, G Ashrafi, G Twig, G Twig, GD Cartee, H Abeliovich, H Deng, H Nakatogawa, I Pimenta de Castro, IP Castro de, J Durieux, J Park, J Yun, JM Copeland, JP Leduc-Gaudet, K Kavanagh, K Mao, K Palikaras, L Buhlman, L Partridge, L Poirier, M Frank, M Kaeberlein, M Manczak, M Rera, M Rera, M Schrader, MJ Drummond, N Sun, N Sun, N Thevaranjan, NC Chan, P Reis-Rodrigues, R Coleman, R Kandimalla, RH Houtkooper, RJ Youle, RJ Youle, S Geisler, S Gelino, S Hoppins, S Iqbal, SE Wohlgemuth, WW Ja, X Wang, Y Wang, Y Yang   +72 more
core   +6 more sources

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database [PDF]

, 2017
SCOPE: The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites ...
Andrés Lacueva, Ma. Cristina, Barupal, Dinesh Kumar, Boto Ordóñez, María, Farran, Andreu, Llorach, Rafael, Manach, Claudine, Neveu, Vanessa, Rothwell, Joseph A., Scalbert, Augustin, Urpí Sardà, Mireia   +9 more
core   +1 more source

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]

, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Fernando B, Garg ML, Guillemin GJ, Hone E, Jayatunga DPW, Khaira H, Lunelli T, Martins RN, Singh H, Verdile G   +9 more
core   +2 more sources

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

Supplementation of Weizmannia coagulans BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice

Microorganisms, 2023
The probiotic Weizmannia coagulans (W. coagulans) BC2000 can increase the abundance of intestinal transforming ellagic acid (EA) bacteria and inhibit metabolic disorders caused by hyperlipidemia by activating liver autophagy.
Long Jin, Hongyang Dang, Jinyong Wu, Lixia Yuan, Xiangsong Chen, Jianming Yao   +5 more
doaj   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Process Optimization and Quality Evaluation of Pomegranate Juice Yogurt Fermented with Streptococcus thermophilus FUA329

Shipin gongye ke-ji
Metabolizing ellagic acid (EA) to urolithin A with numerous bioactivities significantly improve the nutritional value of food rich in EA. In the present study, Streptococcus thermophilus FUA329 was applied to prepare pomegranate juice yogurt.
Yichen HUANG, Ziyan HUA, Gewen ZHANG, Shu LIU, Xiaoyue HOU, Kexin CHI, Guang YANG, Xiang ZHOU, Yaowei FANG   +8 more
doaj   +1 more source