Results 81 to 90 of about 354 (136)

Urolithin [PDF]

, 2020
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Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1

Scientific Reports
Osteosarcoma is an aggressive malignancy marked by a high incidence of local recurrence and distant metastasis, leading to poor outcomes in advanced stages.
Abdolreza Ahmadi, Fatemehsadat Hosseini, Milad Iranshahy, Fatemeh B. Rassouli   +3 more
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Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy

Journal of Cachexia, Sarcopenia and Muscle
Background Spinal muscular atrophy (SMA) is a health‐ and life‐limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that ...
Andrew I. Mikhail, Sean Y. Ng, Donald Xhuti, Magda A. Lesinski, Jennifer Chhor, Marc‐Olivier Deguise, Yves De Repentigny, Joshua P. Nederveen, Rashmi Kothary, Mark A. Tarnopolsky, Vladimir Ljubicic   +10 more
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Urolithin A blocks colorectal cancer progression by AKT1 inhibition–driven immune activation

Scientific Reports
Colorectal cancer (CRC) is one of the most common and lethal malignancies worldwide, with its initiation and progression closely linked to metabolic reprogramming, abnormal cell proliferation, and immune evasion.
Ziquan Sun, Jingtao Li, Hongsheng Chen, Zhongxu Zhang, Yingnan Zhang, Yang Wang, Zewen Chang, Fangfang Bi, Jiaojiao Dong, Zhongsheng Chen, Ming Liu   +10 more
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First Reported Human Cases of Urolithin A Renal Calculi

Kidney International Reports
Sara L. Best, Valentinas Gruzdys, Mark White, Natalia Gromadzka, Benjamin Owen, Yongbo Zhang, John R. Asplin   +6 more
doaj   +1 more source

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The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

Current Cancer Drug Targets, 2022
Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...

exaly   +3 more sources

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
MENA PARRENO, Pedro Miguel, DALL'ASTA, Margherita, CALANI, Luca, BRIGHENTI, Furio, DEL RIO, Daniele   +4 more
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The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu, Zhuanhong Liu
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Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su   +3 more
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Research progress of ellagitannin intestinal metabolite urolithins

China Journal of Chinese Materia Medica, 2016
Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou, Zhen-Peng, Qiu, Hui-Lan, Yi, Ding-Shan, Zhou, Jing, Wang, Yue, Wu   +5 more
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