Results 91 to 100 of about 4,964 (226)

Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

Molecular Medicine, 2022
Background Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation (CMT).
Pengfei Chen, Junyu Pei, Xiaopu Wang, Shi Tai, Liang Tang, Xinqun Hu   +5 more
doaj   +1 more source

Development of personalised functional foods needs metabolic profiling [PDF]

, 2014
Purpose of review There is growing interest in applying metabolic profiling technologies to food science as this approach is now embedded into the foodomics toolbox. This review aims at exploring how metabolic profiling can be applied to the development
Claus, Sandrine Paule
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Ellagitannins (Ellagic Acid, Urolithin A, Urolithin B) Inhibit the Catalytic Activity of Human Recombinant Metalloproteinase 9

Iranian Journal of Pharmaceutical Research
Background: Ellagitannins are well-recognized for their antioxidant, chemopreventive, anti-inflammatory, and neuroprotective efficacy. Due to their poor absorption and extensive catabolism, it is proposed that urolithins, as ellagic acid (EA) metabolites, are the real active molecules exerting these biological functions.
Houssein-Zadeh, Nigar, Sadeghi, Leila, Dehghan, Gholamreza   +2 more
openaire   +2 more sources

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Journal of Inflammation, 2020
Background Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults.
Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang, Zhi-yong Ruan   +7 more
doaj   +1 more source

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

Experimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi, Josh Thorley, Ana Rodriguez‐Mateos, Zicheng Zhang, Lewis J James, Tom Clifford   +5 more
wiley   +1 more source

Gut microbiota functions: metabolism of nutrients and other food components [PDF]

, 2017
The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As
A Alonso, A Belenguer, A Bordbar, A Braune, A Braune, A Duda-Chodak, A El Kaoutari, A Heinken, A Heinken, A Heinken, A Heinken, A Heinken, A Karau, A Marcobal, A Matthies, A Matthies, A Mohammed, A Quartieri, A-HM Emwas, A-M Davila, AF Hofmann, AJ Brown, AK Mallett, Almut Heinken, AR Rechner, AR Zomorrodi, AW Walker, AW Walker, B Goodwin, BE Gustafsson, BE Gustafsson, BV Jones, C Manach, C Noecker, CA Kolmeder, CA Kolmeder, CB Cole, CIR Gill, CJ Ziemer, CS Song, D Couteau, DH Mallonee, E Bauer, EA Franzosa, EA Smith, EM Lenz, EP Halmos, F Abram, F Bastos, F Suarez, F Tomas-Barberan, F Vadder De, FA Tomas-Barberan, FA Tomas-Barberan, FE Rowan, FM McIntosh, G Corona, G Falony, G Frost, G Wu, Glenn Gibson, GR Gibson, GR Gibson, GT Macfarlane, GT Macfarlane, GW Tannock, H Bernstein, H Hirokane, H Kettle, H Kettle, H Roume, H Tazoe, HM Said, I Rowland, Ian Rowland, IEJA Francois, Ines Thiele, J Eldere Van, J Pérez-Jiménez, J Trygg, JA Flick, JC Garcia-Canaveras, JC Young, JG Le Blanc, JH Cummings, JJ Eloranta, JK Nicholson, JM Landete, JM Ridlon, JM Ridlon, Jonathan Swann, JR Marchesi, JR Swann, JT Bjerrum, JW Lampe, K Decroos, K Steliou, K Watanabe, Karen Scott, Kieran Tuohy, KP Scott, KR Stayrook, L Hanske, L Hanske, L Marín, L Tasse, L Tomasova, LA Woollett, LV Hooper, M Begley, M Blaut, M Dabek, M Hermanussen, M Rajilić-Stojanović, M Vital, M Watanabe, M Watanabe, MB Biggs, MD Levitt, MGM Kok, MJ Gosalbes, MJ Hill, MV Selma, N Reichardt, NC Verberkmoes, NE Lewis, O Manor, P Kurdi, P Louis, P Louis, P Louis, P Louis, Palsson BØ, PC Pircher, PG Frick, PG Wolf, PJ Turnbaugh, Q Zhang, R Madsen, R Muñoz-Tamayo, RL Kandell, S El Aidy, S Greenblum, S Katsuma, S Lockyer, S Magnúsdóttir, S Possemiers, SA Gibson, SA Joyce, SD Boyd, SF Lajoie, SH Duncan, SH Duncan, SH Hussaini, SM Houten, SN Steinway, SU Christl, SU Christl, T Clavel, T Clavel, T Shashkova, W Xiong, W-L Wang, WR Russell, WR Russell, WR Wikoff, X Shen, X Wei, Y Wang, Z Wang, Z-L Dai, Z-L Dai   +171 more
core   +3 more sources

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

Food and Chemical Toxicology, 2020
The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers. Urolithins (Uros) are ellagitannins and ellagic acid-derived gut microbiota metabolites that reach high concentrations in the human colon.
GIMENEZ BASTIDA, JUAN ANTONIO, Ávila-Gálvez, María Ángeles, Espín, Juan Carlos, González-Sarrías, Antonio   +3 more
openaire   +3 more sources

The role of polyphenols in modern nutrition [PDF]

, 2017
Polyphenols are found in plant-based foods and beverages, notably apples, berries, citrus fruit, plums, broccoli, cocoa, tea and coffee, and many others. There is substantial epidemiological evidence that a diet high in polyphenol-rich fruit, vegetables,
Actis-Goretta, Actis-Goretta, Arab, Bakuradze, Bhupathiraju, Borges, Brull, Brull, Buitrago-Lopez, Buscemi, Buscemi, Cermak, Cifuentes-Gomez, Conquer, Cooper, Crippa, Ding, Ding, Dower, Dower, Drezner, EFSA NDA Panel (European Food Safety Authority Panel on Dietetic Products, Nutrition and Allergies), Egert, Egert, Ellam, Esposito, Fumeaux, Garcia-Alvarez, Guo, Guo, Hara, Heiss, Hertog, Hollman, Hooper, Hubbard, Jaganath, Jimenez, Jumar, Kay, Kempf, Kerimi, Kim, Lee, Leveques, Loke, Martin, Martini, Mastroiacovo, McAnulty, Mullen, Neilson, Neveu, Nieman, Nishimuro, Olthof, Olthof, Ottaviani, Ottaviani, Pan, Pang, Peluso, Perez-Jimenez, Petri, Pimpao, Pinto, Rhee, Rio, Romo-Vaquero, Santesso, Santos, Scalbert, Schmit, Serafini, Shaposhnikov, Shi, Shi, Stoupi, Urgert, Urgert, Vargas-Murga, Vlachojannis, Vogiatzoglou, Vogiatzoglou, Watanabe, Williamson, Williamson, Williamson, Woodward, Yahya, Yang, Yang, Yang, Zock   +93 more
core   +1 more source