Results 91 to 100 of about 3,740 (205)

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Targeting aging with urolithin A in humans: A systematic review

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, AH, Lim, XK, Khoo, AL, Sandalova, E, Guan, L, Feng, L, Maier, AB   +6 more
openaire   +3 more sources

Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-κB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells

, 2022
Urolithin A is an active compound of gut-microbiota-derived metabolites of polyphenol ellagic acid that has anti-aging, antioxidative, and anti-inflammatory effects.
Chao, Jane C-J, Wu, Shu-Ju, Shen, Szu-Chuan, Szu-Chuan Shen, Jane C-J Chao, Liou, Chian-Jiun, Huang, Wen-Chung, Wen-Chung Huang, Shu-Ju Wu, Hu, Sindy, Chian-Jiun Liou, Chien-Yu Hsiao, Hsiao, Chien-Yu, Sindy Hu   +13 more
core   +1 more source

Process Optimization and Quality Evaluation of Pomegranate Juice Yogurt Fermented with Streptococcus thermophilus FUA329

Shipin gongye ke-ji
Metabolizing ellagic acid (EA) to urolithin A with numerous bioactivities significantly improve the nutritional value of food rich in EA. In the present study, Streptococcus thermophilus FUA329 was applied to prepare pomegranate juice yogurt.
Yichen HUANG, Ziyan HUA, Gewen ZHANG, Shu LIU, Xiaoyue HOU, Kexin CHI, Guang YANG, Xiang ZHOU, Yaowei FANG   +8 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, Volume 3, Issue 2, Page 163-184, June 2026.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells [PDF]

, 2019
Scope: Urolithin A is an anti-inflammatory and neuroprotective gut-derived metabolite from ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT-1 and autophagy in the neuroprotective activity of urolithin A are investigated.
El-Bakoush, Abdelmeneim, Olajide, Olumayokun, Harsharan Bhatia, Katola, Folashade, Velagapudi, Ravikanth, El‐Bakoush, Abdelmeneim, Olumayokun A. Olajide, Ravikanth Velagapudi, Abdelmeneim El‐Bakoush, Bhatia, Harsharan, Lepiarz, Izabela, Fiebich, Bernd L., Bhatia, Harsharan S., Katola, Folashade O., Izabela Lepiarz, Folashade O. Katola, Bernd L. Fiebich, Olajide, Olumayokun A.   +17 more
core   +1 more source

The effects of urolithin A on poly I:C-induced microglial activation [PDF]

Frontiers in Cellular Neuroscience
Neuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain.
Yakum Benard Mingo, Yakum Benard Mingo, Lea Gabele, Lea Gabele, Niklas Lonnemann, Bert Brône, Martin Korte, Martin Korte, Shirin Hosseini, Shirin Hosseini   +9 more
openaire   +4 more sources

Fermentation of Green Tea Extract by Streptococcus thermophilus FUA329 and Evaluation of Storage Characteristics

Shipin gongye ke-ji
In order to evaluate the effect of Streptococcus thermophilus fermentation on green tea extract and its storage characteristics, this study used Streptococcus thermophilus FUA329 and S.
Shuting HAN, Ziyan HUA, Yaowei FANG, Guang YANG, Xiaoyue HOU, Wenmei ZHOU, Ming TANG, Shu LIU   +7 more
doaj   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, Volume 3, Issue 2, June 2026.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source