Results 111 to 120 of about 3,740 (205)

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where we administer a postbiotic compound ...
Evans, Mal, Aebischer, Patrick, Fouassier, Andreane M., Blanco-Bose, William, Rinsch, Chris, D'Amico, Davide, Singh, Anurag, Auwerx, Johan, Andreux, Penelope A.   +8 more
core   +1 more source

Urolithin A prevents age-related hearing loss by mitophagy induction in C57BL/6J mice

Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data)
core   +1 more source

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

, 2016
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries ...
Nicolet-dit-Félix, Amandine A, Norman Moullan, Moullan, Norman, WILLIAMS, Evan, Dongryeol Ryu, Auwerx, Johan, Huzard, Damien, Chris Rinsch, Andreux, Penelope A., Nicolet-Dit-Felix, Amandine A., Amandine A Nicolet-dit-Félix, Aebischer, Patrick, Patrick Aebischer, Carmen Sandi, Johan Auwerx, Williams, Evan G, Pénélope A Andreux, Elena Katsyuba, Mouchiroud, Laurent, Giuseppe Lo Sasso, Pooja Jha, Damien Huzard, Ryu, Dongryeol, Andreux, Pénélope A, Jha, Pooja, Lo Sasso, Giuseppe, Rinsch, Chris, Evan G Williams, Sandi, Carmen, Katsyuba, Elena, Laurent Mouchiroud   +30 more
core   +1 more source

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial

IMPORTANCE Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A is a natural gut microbiome-derived food metabolite that has been shown to stimulate mitophagy and improve muscle function in older animals
Garcia, Jose M., Liu, Sophia, Aebischer, Patrick, Rinsch, Chris, D'Amico, Davide, Bhayana, Saakshi, Singh, Anurag, Shankland, Eric, Marcinek, David J.   +8 more
core   +1 more source

A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol

, 2009
7 páginas, 1 figura, 1 tabla, 4 esquemasA simple and direct strategy to chemically synthesize O-β-d-glucuronides of urolithin-B 4, resveratrol 5, and the corresponding hydroxytyrosol derivatives 6, 7 (as a regioisomeric mixture), and 8 is described.
Alcántara, David, Morales, Juan Carlos, Lucas, Ricardo   +2 more
core   +1 more source

Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo

, 2022
The present invention relates to a new bacterial strain and a new urolithin named urolithin G. The new strain of the invention is Enterocloster bolteae CEBAS S4A9 DSM 34392 and can customize urolithin production to mimic metabotype A and metabotype B in ...
Beltrán Riquelme, David, Selma, María Victoria, Tomás Barberán, Francisco, García-Villalba, Rocío, Espín de Gea, Juan Carlos   +4 more
core  

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Urolithin [PDF]

, 2020
openaire   +1 more source

Effect of Urolithin A on Bovine Sperm Capacitation and In Vitro Fertilization

Animals
Reactive oxygen species (ROS) play a critical role in the functional competence of sperm cells. Conversely, excessive generation of ROS can impair sperm function, including their fertilization ability. Urolithin A (UA), a gut bacteria-derived metabolite produced from the transformation of ellagitannins, with anti-aging and antioxidant properties, was ...
Manuela Jorge, Filipa C. Ferreira, Carla C. Marques, Maria C. Batista, Paulo J. Oliveira, F. Lidon, Sofia C. Duarte, José Teixeira, Rosa M. L. N. Pereira   +8 more
openaire   +3 more sources

Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1

Scientific Reports
Osteosarcoma is an aggressive malignancy marked by a high incidence of local recurrence and distant metastasis, leading to poor outcomes in advanced stages.
Abdolreza Ahmadi, Fatemehsadat Hosseini, Milad Iranshahy, Fatemeh B. Rassouli   +3 more
doaj   +1 more source