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Synthesis of urolithin derivatives and their anti-inflammatory activity
Biochemical and Biophysical Research CommunicationsTwo series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li +5 more
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Appeal of Urolithins from Synthesis to Biological Activities
Journal of Agricultural and Food ChemistryUrolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Urolithins: a Comprehensive Update on their Metabolism, Bioactivity, and Associated Gut Microbiota
Molecular Nutrition and Food Research, 2022Tomás-Barberán F A +2 more
exaly
Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes
Nutrients, 2021Tomás-Barberán F A +2 more
exaly
Targeting aging with urolithin A in humans
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic +6 more
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Urolithin derivatives and methods of use thereof
2023RINSCH CHRISTOPHER L +9 more
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