Results 111 to 120 of about 489,677 (387)

O‐GalNAc Glycosylation Activates MBL‐Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

open access: yesAdvanced Science, EarlyView.
Upregulated glycosyltransferase GALNT9 in neuroendocrine (NE) carcinomas increases O‐GalNAc glycosylation on cell membrane proteins, particularly Annexin‐A2 (ANXA2). Elevated O‐GalNAc glycan induces the binding of NE cancer cells to mannose binding lectin 2 (MBL2), activating the MBL‐MBL associated serine protease (MBL‐MASP) complement pathway in the ...
Xinyu Chen   +24 more
wiley   +1 more source

Sex-associated differences in baseline urinary metabolites of healthy adults. [PDF]

open access: yes, 2018
The biological basis for gender variability among disease states is not well established. There have been many prior efforts attempting to identify the unique urine metabolomic profiles associated with specific diseases.
Anger, Jennifer T   +6 more
core   +1 more source

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

open access: yesAdvanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan   +15 more
wiley   +1 more source

IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation

open access: yesJournal of Inflammation Research
Renfei Xia,1,* Xiaoyi Shi,2,* Hengcheng Zhang,3,* Wenli Zeng,1 Zhe Yang,4 Jian Xu,1 Jianning Wang,4 Yun Miao,1 Tao Liao1,4 1Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s ...
Xia R   +8 more
doaj  

Nanotechnology in Urology

open access: yesIndian Journal of Urology, 2017
Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr.
openaire   +4 more sources

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma   +11 more
wiley   +1 more source

A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation

open access: yesJournal of Inflammation Research
Yifan Liu,1,* Jiangui Liu,1,* Yuanan Li,1,* Zihui Zhao,1,* Donghao Lyu,1 Keqin Dong,1 Maodong Wei,1 Runzhi Huang,2 Bingnan Lu,1 Xiuwu Pan1 1Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University
Liu Y   +9 more
doaj  

Bedside Ultrasound in a Case of Blunt Scrotal Trauma

open access: yesWestern Journal of Emergency Medicine, 2013
This case study describes a patient who suffered blunt force trauma to the scrotum. Use of bedsideemergency ultrasound facilitated early diagnosis of a ruptured testicle and allowed for prompturological consultation and timely surgical repair.
Mark Cannis   +2 more
doaj  

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