Results 41 to 50 of about 12,027 (166)

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, Volume 11, Issue 12, 18 June 2026.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Avian pathogenic Escherichia coli (APEC) and uropathogenic Escherichia coli (UPEC): characterization and comparison

The Journal of Infection in Developing Countries, 2021
Introduction: Avian pathogenic E. coli (APEC) and uropathogenic E. coli (UPEC) are responsible for avian colibacillosis and human urinary tract infections, respectively. There are genetic similarities between the APEC and UPEC pathotypes, suggesting the APEC strains could be a potential reservoir of virulence and antimicrobial-resistance genes for the ...
Daniela Tonini da Rocha, Felipe de Oliveira Salle, Karen Apellanis Borges, Thales Quedi Furian, Vladimir Pinheiro do Nascimento, Hamilton Luiz de Souza Moraes, Carlos Tadeu Pippi Salle   +6 more
openaire   +4 more sources

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Promising Approach to Inhibit E. coli FimH Adhesion by C-Linked Mannosides

Proceedings, 2019
Antagonists of the uropathogenic Escherichia coli type-1 fimbrial adhesin (FimH) are recognized as attractive alternatives for antibiotic therapies and prophylactic strategies against acute and recurrent bacterial infections. [...]
Leila Mousavifar, René Roy
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Novel antibacterial agents are urgently needed to address the infections caused by multi-drug resistant bacteria. Urinary tract infections are common infectious diseases in clinical.
Liang Peng, Liting Zeng, Hongwei Jin, Lixin Yang, Yi Xiao, Ziquan Lan, Zhanpeng Yu, Shi Ouyang, Liangren Zhang, Ning Sun   +9 more
doaj   +1 more source

RNAs Associated With Bacterial Outer Membrane Vesicles: Structural Insights Into Surface Composition

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
This work uncovers a new layer of bacterial communication. We show that RNAs, aided by the Hfq RNA‐chaperone, are not only packed inside Gram negative Outer Membrane Vesicles (OMVs) but can also be embedded in their membranes. This suggests that bacteria may use surface‐exposed RNAs to directly interact with host cells. Overall, our results broaden the
Kevin Mosca, Florian Turbant, Wafa Achouak, Frank Wien, Véronique Arluison   +4 more
wiley   +1 more source

UropathogenicEscherichia coli-Associated Exotoxins [PDF]

Microbiology Spectrum, 2016
ABSTRACTEscherichia coliare a common cause of infectious disease outside of the gastrointestinal tract. Several independently evolvedE. coliclades are common causes of urinary tract and bloodstream infections. There is ample epidemiological andin vitroevidence that several different protein toxins common to many, but not all, of these strains are ...
openaire   +2 more sources

A Population-Based Surveillance Study of Shared Genotypes of Escherichia coli Isolates from Retail Meat and Suspected Cases of Urinary Tract Infections

mSphere, 2018
There is increasing evidence that retail food may serve as a source of Escherichia coli that causes community-acquired urinary tract infections, but the impact of this source in a community is not known. We conducted a prospective, population-based study
Reina Yamaji, Cindy R. Friedman, Julia Rubin, Joy Suh, Erika Thys, Patrick McDermott, Melody Hung-Fan, Lee W. Riley   +7 more
doaj   +1 more source

Modulation of Quorum Sensing and Virulence Gene Expression in Escherichia coli by Extracts of Physalis alkekengi

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Root extracts of Physalis alkekengi were examined for activity against multidrug‐resistant (MDR) Escherichia coli. The ethanolic extract suppressed bacterial growth, lowered biofilm formation by ~63%, and markedly reduced expression of luxS and fimH. Findings highlight P.
Mansoureh Esfandiyari Doolaby, Mohammad Javad Mehdipour Moghaddam, Akbar Norastehnia   +2 more
wiley   +1 more source