Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, EarlyView.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
Promising Approach to Inhibit E. coli FimH Adhesion by C-Linked Mannosides
Proceedings, 2019 Antagonists of the uropathogenic Escherichia coli type-1 fimbrial adhesin (FimH) are recognized as attractive alternatives for antibiotic therapies and prophylactic strategies against acute and recurrent bacterial infections. [...]
Leila Mousavifar, René Roy
doaj +1 more source
Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Novel antibacterial agents are urgently needed to address the infections caused by multi-drug resistant bacteria. Urinary tract infections are common infectious diseases in clinical.
Liang Peng +9 more
doaj +1 more source
Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific. [PDF]
, 2012 BACKGROUND: Ureters are fundamental for keeping kidneys free from uropathogenic Escherichia coli (UPEC), but we have shown that 2 strains (J96 and 536) can subvert this role and reduce ureteric contractility. To determine whether this is (1) a widespread
Abe +34 more
core +2 more sources
The role of iron in normal and impaired testicular function
Andrology, EarlyView.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source
An “omics” approach to uropathogenic Escherichia coli vaccinology [PDF]
Trends in Microbiology, 2009 Urinary tract infection (UTI) occurs when bacteria, most commonly uropathogenic Escherichia coli (UPEC) [1], contaminate the periurethral area and traverse the urethra to colonize the bladder. Left untreated, UPEC ascend the ureters and establish a secondary infection in the kidney parenchyma.
Kelsey E, Sivick, Harry L T, Mobley
openaire +2 more sources
Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection [PDF]
, 2013 Urinary tract infections (UTI) are among the most common infectious diseases of humans and are the most common nosocomial infections in the developed world.
Carey, A. J. +5 more
core +2 more sources
Water, water, every where—the advent of hydrated pili structure
The FEBS Journal, EarlyView.Protein structure is defined by its surrounding water. Naturally, this is also true for the gigantic protein filaments that pathogenic bacteria use to attach to and colonize their host cells. Structures of these filaments for which water can be identified with high confidence have stayed elusive for the longest time.
Hiroya Oki +3 more
wiley +1 more source
Genome Sequence of AvianEscherichia coliStrain IHIT25637, an Extraintestinal PathogenicE. coliStrain of ST131 Encoding Colistin Resistance Determinant MCR-1 [PDF]
, 2016 Sequence type 131 (ST131) is one of the predominant Escherichia coli lineages among extraintestinal pathogenic E. coli (ExPEC) that causes a variety of diseases in humans and animals and frequently shows multidrug resistance.
Bauerfeind, Rolf +8 more
core +2 more sources
Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Cardiovascular event rates rise after acute infections. After a single pyelonephritis episode in Ldlr−/− mice, atherosclerotic plaque necrotic core size increased, mediated by chemokine receptor CCR2‐induced monocyte mobilization from the bone marrow.
Lena Possenriede +10 more
wiley +1 more source