Results 71 to 80 of about 522,586 (301)

Vaccination approaches for the prevention of urinary tract infection [PDF]

, 2013
Urinary tract infections (UTIs) are one of the most common infectious diseases of humans, with approximately 150 million cases estimated to occur globally every year. UTIs usually start as a bladder infection (cystitis), but can develop into acute kidney
Moriel, Danilo G., Schembri, Mark A.
core   +1 more source

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]

, 2017
Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W, Gross, Michael L, Hannan, Thomas J, Hibbing, Michael E, Holehouse, Alex S, Hultgren, Scott J, Janetka, James, Kalas, Vasilios, Pappu, Rohit V, Pinkner, Jerome S, Tolia, Niraj H, Zhang, Hao   +11 more
core   +3 more sources

Ybcl of uropathogenic escherichia coli suppresses transepithelial neutrophil migration [PDF]

, 2012
Uropathogenic Escherichia coli (UPEC) strains suppress the acute inflammatory response in the urinary tract to ensure access to the intracellular uroepithelial niche that supports the propagation of infection. Our understanding of this initial cross talk
Hunstad, David A, Lau, Megan E, Loughman, Jennifer A   +2 more
core   +2 more sources

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie International Edition, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +1 more source

Bacterial Profile of Urinary Tract Infections: Evaluation of Biofilm Formation and Antibiotic Resistance Pattern of Uropathogenic Escherichia coli

Journal of Pure and Applied Microbiology, 2020
Urinary tract infection (UTI) is one of the most common complaints in the outpatient clinic and a major health problem owing to the emergence of antibiotic resistance and biofilm formation.
Tariq Ahmad Shah, P. Preethishree, Ashwini, Vidya Pai   +3 more
doaj   +1 more source

Urinary tract infections in pregnancy : studies in vivo and in vitro [PDF]

, 2017
The risk of urinary tract infection (UTI) in pregnant women is increased and predisposes them to acute pyelonephritis together with poor pregnancy outcomes.
Sekikubo, Musa
core   +1 more source

Enhanced Microbial Sensing via Resazurin Reduction Catalyzed by Graphene Oxide, A Versatile Approach for Diagnostics and Electrochemical Applications

Environmental Toxicology, EarlyView.
ABSTRACT Resazurin is a cell viability phenoxazine dye widely employed for bacterial monitoring, as its colorimetric and fluorometric conversion reflects microbial metabolic activity. In this work, we demonstrate that graphene oxide (GO), a two‐dimensional nanomaterial with high surface reactivity, markedly accelerates the reduction of resazurin in the
Valentina Palmieri, Marco de Spirito, Massimiliano Papi   +2 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

An “omics” approach to uropathogenic Escherichia coli vaccinology [PDF]

Trends in Microbiology, 2009
Urinary tract infection (UTI) occurs when bacteria, most commonly uropathogenic Escherichia coli (UPEC) [1], contaminate the periurethral area and traverse the urethra to colonize the bladder. Left untreated, UPEC ascend the ureters and establish a secondary infection in the kidney parenchyma.
Kelsey E, Sivick, Harry L T, Mobley
openaire   +2 more sources

Distribution of virulence genes and phylogenetics of uropathogenic Escherichia coli among urinary tract infection patients in Addis Ababa, Ethiopia

BMC Infectious Diseases, 2019
Urinary tract infection (UTI) is a common cause of morbidity worldwide. Uropathogenic Escherichia coli (UPEC) bacteria are the major cause of urinary tract infections.
Belayneh Regasa Dadi, T. Abebe, Lixin Zhang, A. Mihret, W. Abebe, W. Amogne   +5 more
semanticscholar   +1 more source